Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Michael P. Meers"'
Autor:
Derek H. Janssens, Dominik J. Otto, Michael P. Meers, Manu Setty, Kami Ahmad, Steven Henikoff
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-19 (2022)
Abstract Cleavage Under Targets and Tagmentation (CUT&Tag) is an antibody-directed transposase tethering strategy for in situ chromatin profiling in small samples and single cells. We describe a modified CUT&Tag protocol using a mixture of an antibod
Externí odkaz:
https://doaj.org/article/2363434c279348e18326a59aafb527f7
Autor:
Maged Zeineldin, Sara Federico, Xiang Chen, Yiping Fan, Beisi Xu, Elizabeth Stewart, Xin Zhou, Jongrye Jeon, Lyra Griffiths, Rosa Nguyen, Jackie Norrie, John Easton, Heather Mulder, Donald Yergeau, Yanling Liu, Jianrong Wu, Collin Van Ryn, Arlene Naranjo, Michael D. Hogarty, Marcin M. Kamiński, Marc Valentine, Shondra M. Pruett-Miller, Alberto Pappo, Jinghui Zhang, Michael R. Clay, Armita Bahrami, Peter Vogel, Seungjae Lee, Anang Shelat, Jay F. Sarthy, Michael P. Meers, Rani E. George, Elaine R. Mardis, Richard K. Wilson, Steven Henikoff, James R. Downing, Michael A. Dyer
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-20 (2020)
In most cancers, mutations that lead to oncogene activation and tumor suppressor inactivation synergize to promote tumorigenesis. However, in neuroblastomas, MYCN amplification and ATRX mutations are mutually exclusive and incompatible.
Externí odkaz:
https://doaj.org/article/08a87c1bf95d4f798e9e0d5a7daabd61
Publikováno v:
Epigenetics & Chromatin, Vol 12, Iss 1, Pp 1-11 (2019)
Abstract Background CUT&RUN is an efficient epigenome profiling method that identifies sites of DNA binding protein enrichment genome-wide with high signal to noise and low sequencing requirements. Currently, the analysis of CUT&RUN data is complicat
Externí odkaz:
https://doaj.org/article/eb25c6ab45174aa2805808b7c0d72d76
Autor:
Derek H. Janssens, Steven J. Wu, Jay F. Sarthy, Michael P. Meers, Carrie H. Myers, James M. Olson, Kami Ahmad, Steven Henikoff
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-14 (2018)
Abstract Background Our understanding of eukaryotic gene regulation is limited by the complexity of protein–DNA interactions that comprise the chromatin landscape and by inefficient methods for characterizing these interactions. We recently introdu
Externí odkaz:
https://doaj.org/article/c7b93f6a290149ae84ea89579b7bf8dc
Autor:
Michael P. Meers, Karen Adelman, Robert J. Duronio, Brian D. Strahl, Daniel J. McKay, A. Gregory Matera
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-20 (2018)
Abstract Background High-resolution transcription start site (TSS) mapping in D. melanogaster embryos and cell lines has revealed a rich and detailed landscape of both cis- and trans-regulatory elements and factors. However, TSS profiling has not bee
Externí odkaz:
https://doaj.org/article/7a89212ac91d47e7bbb38f4f071a3e5f
Publikováno v:
Nature Biotechnology. 41:708-716
Chromatin profiling at locus resolution uncovers gene regulatory features that define cell types and developmental trajectories, but it remains challenging to map and compare different chromatin-associated proteins in the same sample. Here we describ
Autor:
Gavin Ha, Peter S. Nelson, Steven Henikoff, Eva Corey, R. Bruce Montgomery, Michael C. Haffner, Kami Ahmad, Matthew L. Freedman, Jacob E. Berchuck, Sylvan C. Baca, Atish D. Choudhury, Colm Morrissey, Michael T. Schweizer, Colin C. Pritchard, Heather M. McClure, Holly M. Nguyen, Talina A. Nunez, Jared M. Lucas, Ruth F. Dumpit, Arnab Bose, Ilsa M. Coleman, Lisa S. Ang, Derek H. Janssens, Michael P. Meers, Sandipan Brahma, Minjeong Ko, Jay F. Sarthy, Adam J. Kreitzman, Mohamed Adil, Brian Hanratty, Anna-Lisa Doebley, Robert D. Patton, Navonil De Sarkar
Feature-region combination AUCs and benchmarking Sheet 1: Log2 fold-change, p-value, and q-value between ARPC and NEPC lines for central mean coverage in all queried (338) TFs (two tailed Mann-Whitney U test, Benjamini-Hochberg adjusted). Sheet 2: 10
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::131f41ff743e41934b8e4242f49253ae
https://doi.org/10.1158/2159-8290.22674256
https://doi.org/10.1158/2159-8290.22674256
Autor:
Gavin Ha, Peter S. Nelson, Steven Henikoff, Eva Corey, R. Bruce Montgomery, Michael C. Haffner, Kami Ahmad, Matthew L. Freedman, Jacob E. Berchuck, Sylvan C. Baca, Atish D. Choudhury, Colm Morrissey, Michael T. Schweizer, Colin C. Pritchard, Heather M. McClure, Holly M. Nguyen, Talina A. Nunez, Jared M. Lucas, Ruth F. Dumpit, Arnab Bose, Ilsa M. Coleman, Lisa S. Ang, Derek H. Janssens, Michael P. Meers, Sandipan Brahma, Minjeong Ko, Jay F. Sarthy, Adam J. Kreitzman, Mohamed Adil, Brian Hanratty, Anna-Lisa Doebley, Robert D. Patton, Navonil De Sarkar
Supplementary Figures S1-S18 and Supplementary Table legends.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a676746f9874d80588b96e87e41d0812
https://doi.org/10.1158/2159-8290.22674268.v1
https://doi.org/10.1158/2159-8290.22674268.v1
Autor:
Harmony R. Salzler, Vasudha Vandadi, Benjamin D. McMichael, John C. Brown, Sally A. Boerma, Mary P. Leatham-Jensen, Kirsten M. Adams, Michael P. Meers, Jeremy M. Simon, Robert J. Duronio, Daniel J. McKay, A. Gregory Matera
Publikováno v:
Science Advances. 9
Polycomb complexes regulate cell type–specific gene expression programs through heritable silencing of target genes. Trimethylation of histone H3 lysine 27 (H3K27me3) is essential for this process. Perturbation of H3K36 is thought to interfere with
Autor:
Navonil De Sarkar, Robert D. Patton, Anna-Lisa Doebley, Brian Hanratty, Mohamed Adil, Adam J. Kreitzman, Jay F. Sarthy, Minjeong Ko, Sandipan Brahma, Michael P. Meers, Derek H. Janssens, Lisa S. Ang, Ilsa M. Coleman, Arnab Bose, Ruth F. Dumpit, Jared M. Lucas, Talina A. Nunez, Holly M. Nguyen, Heather M. McClure, Colin C. Pritchard, Michael T. Schweizer, Colm Morrissey, Atish D. Choudhury, Sylvan C. Baca, Jacob E. Berchuck, Matthew L. Freedman, Kami Ahmad, Michael C. Haffner, R. Bruce Montgomery, Eva Corey, Steven Henikoff, Peter S. Nelson, Gavin Ha
Publikováno v:
Cancer discovery.
Advanced prostate cancers comprise distinct phenotypes, but tumor classification remains clinically challenging. Here, we harnessed circulating tumor DNA (ctDNA) to study tumor phenotypes by ascertaining nucleosome positioning patterns associated wit