Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Michael P. McCabe"'
Autor:
Georgios Vlasakakis, Michael T. McCabe, Yu Liu Ho, Geraldine Ferron‐Brady, Paul Martin, Darren Bentley, Catherine Ellis, Mary Antonysamy, Sandra A. G. Visser
Publikováno v:
Clinical and Translational Science, Vol 17, Iss 8, Pp n/a-n/a (2024)
Abstract Myelofibrosis is a chronic myeloproliferative disorder characterized by bone marrow fibrosis, splenomegaly, anemia, and constitutional symptoms, with a median survival of ≈6 years from diagnosis. While currently approved Janus kinase (JAK)
Externí odkaz:
https://doaj.org/article/007db636c4c9495b90b6e087de2b9aef
Autor:
Ashley K. Wiseman, Rochelle L. Tiedemann, Huihui Fan, Hui Shen, Zachary Madaj, Michael T. McCabe, Melissa B. Pappalardi, Peter A. Jones
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-10 (2022)
Chromosome specific retention of cancer associated DNA hypermethylation following pharmacological inhibition of DNMT1 is shown, with residual CpG methylation on the X chromosome compared to autosomes, suggesting a separate mechanism of methylation.
Externí odkaz:
https://doaj.org/article/f61392dc449b4ea58f124af35530403b
Autor:
Jiajia Dai, Hyangin Kim, Zerong You, Michael F. McCabe, Shuzhuo Zhang, Shiyu Wang, Grewo Lim, Lucy Chen, Jianren Mao
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
The reduced antidepressant and antihyperalgesic effects of selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine during maintenance treatment has been reported, but little is known about the molecular mechanism of this phenomenon. In thr
Externí odkaz:
https://doaj.org/article/de864ada10de4337b218cde94cab6a09
Autor:
Aidan G. Gilmartin, Arthur Groy, Elizabeth R. Gore, Charity Atkins, Edward R. Long, Monica N. Montoute, Zining Wu, Wendy Halsey, Dean E. McNulty, Daniela Ennulat, Lourdes Rueda, Melissa Pappalardi, Ryan G. Kruger, Michael T. McCabe, Ali Raoof, Roger Butlin, Alexandra Stowell, Mark Cockerill, Ian Waddell, Donald Ogilvie, Juan Luengo, Allan Jordan, Andrew B. Benowitz
Publikováno v:
Haematologica, Vol 106, Iss 7 (2020)
Pharmacological induction of fetal hemoglobin (HbF) expression is an effective therapeutic strategy for the management of beta-hemoglobinopathies such as sickle cell disease. DNA methyltransferase (DNMT) inhibitors 5-azacytidine (5-aza) and 5-aza-2
Externí odkaz:
https://doaj.org/article/375cf7300ce44f4d81582faca63eef19
Autor:
Kimberly N. Smitheman, Tesa M. Severson, Satyajit R. Rajapurkar, Michael T. McCabe, Natalie Karpinich, James Foley, Melissa B. Pappalardi, Ashley Hughes, Wendy Halsey, Elizabeth Thomas, Christopher Traini, Kelly E. Federowicz, Jenny Laraio, Fredrick Mobegi, Geraldine Ferron-Brady, Rabinder K. Prinjha, Christopher L. Carpenter, Ryan G. Kruger, Lodewyk Wessels, Helai P. Mohammad
Publikováno v:
Haematologica, Vol 104, Iss 6 (2019)
Lysine specific demethylase 1 (LSD1) is a histone modifying enzyme that suppresses gene expression through demethylation of lysine 4 on histone H3. The anti-tumor activity of GSK2879552 and GSK-LSD1, potent, selective irreversible inactivators of LSD
Externí odkaz:
https://doaj.org/article/bb08125c1aa14689b48e6b606c7f9587
Publikováno v:
Arthroscopy Techniques, Vol 4, Iss 6, Pp e775-e779 (2015)
Improved battlefield survival rates have resulted in a significant number of young active patients with lower-extremity amputations. Because of the increased demands placed on their hips, patients with amputations may be more susceptible to the seque
Externí odkaz:
https://doaj.org/article/ff7e43cf62644cd99a9550a926f2fe31
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0124195 (2015)
Melatonin plays a protective role in type 2 diabetes (T2D) through regulation of glucose metabolism. Whether transcutaneous vagus nerve stimulation (taVNS) is antidiabetic and whether a modulated melatonin production is involved in the antidiabetic m
Externí odkaz:
https://doaj.org/article/fc62588be15343d58177c3fbdb41c1c6
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 7, Iss 2, Pp 141-151 (2005)
The retinoblastoma tumor suppressor (pRb) has traditionally been studied as a negative regulator of cell cycle progression through its interactions with the E2F family of transcription factors. Utilizing prostate epithelial cell lines established fro
Externí odkaz:
https://doaj.org/article/8209d0dd7fed4a69bf4a317798715d0b
Autor:
Shaoyuan Li, Xu Zhai, Peijing Rong, Michael F McCabe, Xing Wang, Jingjun Zhao, Hui Ben, Shuxing Wang
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112066 (2014)
Depression and type 2 diabetes (T2D) are common comorbid diseases and highly prevalent in the clinical setting with an unclarified mechanism. Zucker diabetic fatty (ZDF, fa/fa) rats natively develop T2D with hyperglycemia and hyperinsulinemia. Here w
Externí odkaz:
https://doaj.org/article/d399d927feb147a284dab87a17912846
Autor:
Shaoyuan Li, Xu Zhai, Peijing Rong, Michael F McCabe, Jingjun Zhao, Hui Ben, Xing Wang, Shuxing Wang
Publikováno v:
PLoS ONE, Vol 9, Iss 10, p e111100 (2014)
Decreased circulating melatonin is implicated in depression. We recently found that Zucker diabetic fatty rats (ZDF, fa/fa) develop depression-like behaviors and that transcutaneous auricular vagus nerve stimulation (taVNS) is antidepressive in ZDF r
Externí odkaz:
https://doaj.org/article/82fc37b7a61747de95ab62212b5ed9df