Výsledky vyhledávání - "Michael P. Marciel"

Akademický článek

ST6GAL1 sialyltransferase promotes acinar to ductal metaplasia and pancreatic cancer progression

Publikováno v: JCI Insight, Vol 8, Iss 19 (2023)

The role of aberrant glycosylation in pancreatic ductal adenocarcinoma (PDAC) remains an under-investigated area of research. In this study, we determined that ST6 β-galactoside α2,6 sialyltransferase 1 (ST6GAL1), which adds α2,6-linked sialic aci

Externí odkaz: https://doaj.org/article/8d74b6365a7e4f5aab8310300004ced9

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Akademický článek

Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation

Autor: Chi Ma, FuKun W. Hoffmann, Michael P. Marciel, Kathleen E. Page, Melodie A. Williams-Aduja, Ellis N.L. Akana, Greg S. Gojanovich, Mariana Gerschenson, Johann Urschitz, Stefan Moisyadi, Vedbar S. Khadka, Sharon Rozovsky, Youping Deng, F. David Horgen, Peter R. Hoffmann

Publikováno v: Molecular Metabolism, Vol 47, Iss , Pp 101170- (2021)

Objective: T cell activation triggers metabolic reprogramming to meet increased demands for energy and metabolites required for cellular proliferation. Ethanolamine phospholipid synthesis has emerged as a regulator of metabolic shifts in stem cells a

Externí odkaz: https://doaj.org/article/b5d150d02a4340998f52553c81f6b89c

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Akademický článek

Targeting the C-terminus of galectin-9 induces mesothelioma apoptosis and M2 macrophage depletion

Autor: Pietro Bertino, Thomas A. Premeaux, Tsuyoshi Fujita, Brien K. Haun, Michael P. Marciel, Fukun W. Hoffmann, Alan Garcia, Haining Yiang, Sandra Pastorino, Michele Carbone, Toshiro Niki, John Berestecky, Peter R. Hoffmann, Lishomwa C. Ndhlovu

Publikováno v: OncoImmunology, Vol 8, Iss 8 (2019)

Galectin-9 has emerged as a promising biological target for cancer immunotherapy due to its role as a regulator of macrophage and T-cell differentiation. In addition, its expression in tumor cells modulates tumor cell adhesion, metastasis, and apopto

Externí odkaz: https://doaj.org/article/41f44ac964e842d0b0aac2d107a28d91

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Regulation of ST6GAL1 sialyltransferase expression in cancer cells

Autor: Katherine E Ankenbauer, Jihye Hwang, Michael P Marciel, Kaitlyn A. Dorsett, Susan L. Bellis, Nikita Bhalerao

Publikováno v: Glycobiology

The ST6GAL1 sialyltransferase, which adds α2–6 linked sialic acids to N-glycosylated proteins, is overexpressed in a wide range of human malignancies. Recent studies have established the importance of ST6GAL1 in promoting tumor cell behaviors such

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5ef6bb4f85470d9cbb31fcc786181e
https://doi.org/10.1093/glycob/cwaa110

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Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation

Autor: Vedbar S. Khadka, F. David Horgen, Sharon Rozovsky, Peter R. Hoffmann, Greg S. Gojanovich, Michael P. Marciel, Ellis N.L. Akana, Chi Ma, Melodie A. Williams-Aduja, Mariana Gerschenson, Johann Urschitz, FuKun W. Hoffmann, Stefan Moisyadi, Kathleen E. Page, Youping Deng

Publikováno v: Molecular Metabolism
Molecular Metabolism, Vol 47, Iss, Pp 101170-(2021)

Objective T cell activation triggers metabolic reprogramming to meet increased demands for energy and metabolites required for cellular proliferation. Ethanolamine phospholipid synthesis has emerged as a regulator of metabolic shifts in stem cells an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24266bbaef14ae15673068a469ad86aa
https://pubmed.ncbi.nlm.nih.gov/33484950

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Selenoprotein K deficiency inhibits melanoma by reducing calcium flux required for tumor growth and metastasis

Autor: Natalija Glibetic, Pietro Bertino, Michael P. Marciel, Katie Lee, Vedbar S. Khadka, FuKun W. Hoffmann, Suzie Chen, Michelle L. Matter, Andrew Pham, Youping Deng, Peter R. Hoffmann, Pascal Kilicaslan

Publikováno v: Oncotarget

Interest has emerged in the therapeutic potential of inhibiting store operated calcium (Ca2+) entry (SOCE) for melanoma and other cancers because malignant cells exhibit a strong dependence on Ca2+ flux for disease progression. We investigated the ef

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82dce5a78d1e6b128f4171c9f77e49a1
http://europepmc.org/articles/PMC5862587

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Calpain-2 inhibitor treatment preferentially reduces tumor progression for human colon cancer cells expressing highest levels of this enzyme

Autor: Michael P. Marciel, David Horio, Verena Martinez, Aaron H. Rose, Ann S. Hashimoto, Peter R. Hoffmann, FuKun W. Hoffmann, Pietro Bertino

Publikováno v: Cancer Medicine

Calpain‐2 levels are higher in colorectal tumors resistant to chemotherapy and previous work showed calpain‐2 inhibitor therapy reduced inflammation‐driven colorectal cancer, but direct effects of the inhibitor on colon cancer cells themselves

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d634facda66c212e38bd3cf799bf706b
https://doi.org/10.1002/cam4.1260

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