Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Michael P. Major"'
Autor:
Maritza Puray-Chavez, Jenna E. Eschbach, Ming Xia, Kyle M. LaPak, Qianzi Zhou, Ria Jasuja, Jiehong Pan, Jian Xu, Zixiang Zhou, Shawn Mohammed, Qibo Wang, Dana Q. Lawson, Sanja Djokic, Gaopeng Hou, Siyuan Ding, Steven L. Brody, Michael B. Major, Dennis Goldfarb, Sebla B. Kutluay
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Host factors that define the cellular tropism of SARS-CoV-2 beyond the cognate ACE2 receptor are poorly defined. Here we report that SARS-CoV-2 replication is restricted at a post-entry step in a number of ACE2-positive airway-derived cell l
Externí odkaz:
https://doaj.org/article/941914b9381f4ed29c36d7cbcb886821
Autor:
John G. Witherspoon, Jonathan R. Hall, Dereje Jima, Hannah M. Atkins, Nathan T. Wamsley, Michael B. Major, Bernard E. Weissman, Robert C. Smart
Publikováno v:
Redox Biology, Vol 75, Iss , Pp 103261- (2024)
Squamous cell carcinomas (SCCs), including lung, head & neck, bladder, and skin SCCs often display constitutive activation of the KEAP1-NRF2 pathway. Constitutive activation is achieved through multiple mechanisms, including activating mutations in N
Externí odkaz:
https://doaj.org/article/b4b5ffcf237641c591cfcf27bb61b4f8
Autor:
Lingzhen Kong, Chen Cheng, Abigael Cheruiyot, Jiayi Yuan, Yichan Yang, Sydney Hwang, Daniel Foust, Ning Tsao, Emily Wilkerson, Nima Mosammaparast, Michael B. Major, David W. Piston, Shan Li, Zhongsheng You
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract The protection of the replication fork structure under stress conditions is essential for genome maintenance and cancer prevention. A key signaling pathway for fork protection involves TRPV2-mediated Ca2+ release from the ER, which is trigge
Externí odkaz:
https://doaj.org/article/0f9d4eec787842fb898dc9fb70b2dd44
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0297741 (2024)
Prior to the next generation sequencing and characterization of the tumor genome landscape, mutations in the SWI/SNF chromatin remodeling complex and the KEAP1-NRF2 signaling pathway were underappreciated. While these two classes of mutations appeare
Externí odkaz:
https://doaj.org/article/2a7c6899491a413e905e81a7f66f0746
Autor:
Jianan Zhang, Morgan E. Walker, Katherine Z. Sanidad, Hongna Zhang, Yanshan Liang, Ermin Zhao, Katherine Chacon-Vargas, Vladimir Yeliseyev, Julie Parsonnet, Thomas D. Haggerty, Guangqiang Wang, Joshua B. Simpson, Parth B. Jariwala, Violet V. Beaty, Jun Yang, Haixia Yang, Anand Panigrahy, Lisa M. Minter, Daeyoung Kim, John G. Gibbons, LinShu Liu, Zhengze Li, Hang Xiao, Valentina Borlandelli, Hermen S. Overkleeft, Erica W. Cloer, Michael B. Major, Dennis Goldfarb, Zongwei Cai, Matthew R. Redinbo, Guodong Zhang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Triclosan (TCS), an antimicrobial agent commonly found in consumer products, has been reported to exacerbates colitis in animal models. Here, using in vitro and in vivo approaches, the authors show that gut bacterial enzymes can drive the metabolic a
Externí odkaz:
https://doaj.org/article/6effdf9b5b1940eca2eb25770e06d844
Autor:
Zhichuan Zhu, Xin Zhou, Hongwei Du, Erica W. Cloer, Jiaming Zhang, Liu Mei, Ying Wang, Xianming Tan, Austin J. Hepperla, Jeremy M. Simon, Jeanette Gowen Cook, Michael B. Major, Gianpietro Dotti, Pengda Liu
Publikováno v:
Advanced Science, Vol 10, Iss 3, Pp n/a-n/a (2023)
Abstract STING is an innate immune sensor for immune surveillance of viral/bacterial infection and maintenance of an immune‐friendly microenvironment to prevent tumorigenesis. However, if and how STING exerts innate immunity‐independent function
Externí odkaz:
https://doaj.org/article/796291b0707848dcb29d54fda077dfb1
Autor:
Michael W. Major
Publikováno v:
SAGE Open, Vol 12 (2022)
While there is no lack of peer-reviewed publications that focus on resumes, there is a lack of theory-based research in the genre. Most studies on resumes report observations rather than test theories to predict screener behaviors, and recent calls t
Externí odkaz:
https://doaj.org/article/7fd32a8af4074d5196d35944aaa24bc0
Publikováno v:
ACS Omega, Vol 3, Iss 9, Pp 11383-11391 (2018)
Externí odkaz:
https://doaj.org/article/c218721649284385b9d6c91988780c28
Autor:
Yanzhe Gao, Elizabeth Mutter-Rottmayer, Alicia M. Greenwalt, Dennis Goldfarb, Feng Yan, Yang Yang, Raquel C. Martinez-Chacin, Kenneth H. Pearce, Satoshi Tateishi, Michael B. Major, Cyrus Vaziri
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
RAD18 is an important protein in trans-lesion synthesis, an error-prone damage-tolerant mode of DNA replication. Here the authors show that MAGE-A4 stabilizes RAD18 and allows cancer cells to maintain on-going DNA synthesis in the face of genotoxic i
Externí odkaz:
https://doaj.org/article/0e5d0907f6a14928a23a27cda5802f8e
Autor:
Jeran K Stratford, Feng Yan, Rebecca A Hill, Michael B Major, Lee M Graves, Channing J Der, Jen Jen Yeh
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174863 (2017)
Pancreatic ductal adenocarcinoma, which accounts for the majority of pancreatic cancers, is a lethal disease with few therapeutic options. Genomic profiling of pancreatic ductal adenocarcinoma has identified a complex and heterogeneous landscape. Und
Externí odkaz:
https://doaj.org/article/a4307da2b3164585b704755c21db35c6