Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Michael P. Ludwig"'
Autor:
Rani K. Powers, Rachel Culp-Hill, Michael P. Ludwig, Keith P. Smith, Katherine A. Waugh, Ross Minter, Kathryn D. Tuttle, Hannah C. Lewis, Angela L. Rachubinski, Ross E. Granrath, María Carmona-Iragui, Rebecca B. Wilkerson, Darcy E. Kahn, Molishree Joshi, Alberto Lleó, Rafael Blesa, Juan Fortea, Angelo D’Alessandro, James C. Costello, Kelly D. Sullivan, Joaquin M. Espinosa
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Down syndrome (DS) is caused by trisomy 21 (T21), but the underlying etiology of the related immune and neurological dysfunction is unclear. Here, the authors show that T21 activates the kynurenine pathway via increased interferon receptor copy numbe
Externí odkaz:
https://doaj.org/article/ab62f68b2f204b5a960385c4c5866d85
Autor:
Christopher G. Abraham, Michael P. Ludwig, Zdenek Andrysik, Ahwan Pandey, Molishree Joshi, Matthew D. Galbraith, Kelly D. Sullivan, Joaquin M. Espinosa
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3224-3236 (2018)
Summary: The transcriptional repressor ΔNp63α is a potent oncogene widely overexpressed in squamous cell carcinomas (SCCs) of diverse tissue origins, where it promotes malignant cell proliferation and survival. We report here the results of a genom
Externí odkaz:
https://doaj.org/article/60fb82783f564e16bde7d87fedbfa965
Autor:
Michael P. Ludwig, Matthew D. Galbraith, Neetha Paul. Eduthan, Amanda A. Hill, Michael R. Clay, Cristiam Moreno Tellez, Breelyn A. Wilky, Anthony Elias, Joaquín Maximiliano. Espinosa, Kelly D. Sullivan
Publikováno v:
Cancer Research.
Liposarcoma is the most commonly occurring soft tissue sarcoma and is frequently characterized by amplification of chromosome region 12q13-15 harboring the oncogenes MDM2 and CDK4. This unique genetic profile makes liposarcoma an attractive candidate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a54ea5168579523fc47f36426c15039d
https://doi.org/10.1158/0008-5472.can-22-3173
https://doi.org/10.1158/0008-5472.can-22-3173
Publikováno v:
PLoS Genetics, Vol 7, Iss 11, p e1002364 (2011)
The regulatory logic of time- and tissue-specific gene expression has mostly been dissected in the context of the smallest DNA fragments that, when isolated, recapitulate native expression in reporter assays. It is not known if the genomic sequences
Externí odkaz:
https://doaj.org/article/a65d01fba5cf4aa6b26a914aa801676b
Autor:
Rani K. Powers, Michael P. Ludwig, Ross Minter, Angelo D'Alessandro, Ross E Granrath, James C. Costello, Katherine A. Waugh, Darcy E. Kahn, Kathryn D. Tuttle, Molishree Joshi, Angela L. Rachubinski, Rebecca B. Wilkerson, Kelly D. Sullivan, Hannah C Lewis, Keith P Smith, Joaquín M. Espinosa, Rachel Culp-Hill
Trisomy 21 (T21) causes Down syndrome (DS), affecting immune and neurological function by unknown mechanisms. We report here the results of a large metabolomics study showing that people with DS produce elevated levels of kynurenine and quinolinic ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d8858ffb7e95a7272d22a492da66d94
Autor:
Deinsberger, Wolfgang, Vogel, Johannes, Fuchs, Casten, Michael Aueri, Ludwig, Kuschinsky’, Wolfgang, Karsten Böker, Dieter
Publikováno v:
Neurological Research; July 1999, Vol. 21 Issue: 5 p517-523, 7p
Publikováno v:
PLoS Genetics, Vol 16, Iss 11, p e1009216 (2020)
Spatiotemporally precise and robust cell fate transitions, which depend on specific signaling cues, are fundamental to the development of appropriately patterned tissues. The fidelity and precision with which photoreceptor fates are recruited in the
Externí odkaz:
https://doaj.org/article/fabebe063c7d449ca51976bf67bcb882
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e91924 (2014)
Changes in regulatory DNA contribute to phenotypic differences within and between taxa. Comparative studies show that many transcription factor binding sites (TFBS) are conserved between species whereas functional studies reveal that some mutations s
Externí odkaz:
https://doaj.org/article/51a075493ae9411b80b62b5180ab2461
Autor:
Ah-Ram Kim, Carlos Martinez, John Ionides, Alexandre F Ramos, Michael Z Ludwig, Nobuo Ogawa, David H Sharp, John Reinitz
Publikováno v:
PLoS Genetics, Vol 9, Iss 2, p e1003243 (2013)
Rearrangements of about 2.5 kilobases of regulatory DNA located 5' of the transcription start site of the Drosophila even-skipped locus generate large-scale changes in the expression of even-skipped stripes 2, 3, and 7. The most radical effects are g
Externí odkaz:
https://doaj.org/article/6c78c861248240c997533b18afd5ef23
Autor:
Michael Z Ludwig, Arnar Palsson, Elena Alekseeva, Casey M Bergman, Janaki Nathan, Martin Kreitman
Publikováno v:
PLoS Biology, Vol 3, Iss 4, p e93 (2005)
Lack of knowledge about how regulatory regions evolve in relation to their structure-function may limit the utility of comparative sequence analysis in deciphering cis-regulatory sequences. To address this we applied reverse genetics to carry out a f
Externí odkaz:
https://doaj.org/article/ffb9c480d2514707a39ae49b348e934c