Zobrazeno 1 - 10 of 37 pro vyhledávání: '"Michael P. Kotick"'
2
Analgesic narcotic antagonists. 8. 7.alpha.-Alkyl-4,5.alpha.-epoxymorphinan-6-ones
Autor: David L. Leland, Michael P. Kotick, J. F. Howes, Joseph O. Polazzi, Ann R. Bousquet
Publikováno v: Journal of Medicinal Chemistry. 24:1445-1450
The preparation of a series of 7 alpha-alkylated dihydrocodeinones is described. N-(Cyclopropylmethyl) (P series) or N-(cyclobutylmethyl) (B series) 7 alpha-methyl (a series) or 7 alpha, 8 beta-dimethyl (b series) substituted dihydronorcodeinones (7)
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fca3f78cdf2ea71d412ceb4af5a26aeb
https://doi.org/10.1021/jm00144a015
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3
8β-Substituted dihydrocodeinones having heteroatoms in the side chain
Autor: Joseph O. Polazzi, Michael P. Kotick
Publikováno v: Journal of Heterocyclic Chemistry. 18:1029-1033
A series of 8β-substituted dihydrocodeinones, having hetero atoms in the side chain, were prepared. Michael addition of methanol or ethanol to 1 was accomplished under basic conditions, while the nitromethane adduct was prepared by a fluoride ion ca
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a63ec47bf470d99d13f5ea8ae8cd78ac
https://doi.org/10.1002/jhet.5570180535
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4
Analgesic narcotic antagonists. 5. 7,7-Dimethyldihydrocodeinones and 7,7-dimethyldihydromorphinones
Autor: David L. Leland, Michael P. Kotick
Publikováno v: Journal of Medicinal Chemistry. 24:717-721
Treatment of dihydrocodeinone (1a) or the 8 beta-methyl (1b) or 8 beta-ethyl (1c) analogues with formaldehyde-Ca(OH)2 in aqueous dioxane gave the corresponding 7,7-bis(hydroxymethyl)-6 beta-ols 2a-c. Ditosylation of 2, followed by LiEt3BH reduction,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296da3954bb1b1d88ba63f304028e563
https://doi.org/10.1021/jm00138a015
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6
Analgesic narcotic antagonists. 6. 7.beta.,8.beta.-Methano- and 7.beta.,8.beta.-epoxydihydrocodeinone
Autor: Michael P. Kotick
Publikováno v: Journal of Medicinal Chemistry. 24:722-726
Reaction of codeinone (2) with CH2N2 in the presence of Pd(OAc)2 yielded mixtures of starting material and (2) and 7 beta, 8 beta-methanodihydrocodeinone (3). Initial resolution of this mixture was achieved via carbonyl reduction followed by chromato
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5a292143eb37c752c0c27411e309a7b
https://doi.org/10.1021/jm00138a016
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7
Crystal and molecular structure of 5-[1-(2′-deoxy-α-d-ribofuranosyl)uracilyl] disulfide
Autor: Michael P. Kotick, Thomas J. Bardos, Eli Shefter
Publikováno v: Journal of Pharmaceutical Sciences. 56:1293-1299
The molecular structure of 5-[1-(2′-deoxy-α- d -ribofuranosyl) uracilyl] disulfide (I) has been determined by X-ray crystallographic analysis. The molecule crystallizes in the orthorhombic space group P2 1 2 1 2 1 , with the following cell dimensi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01bfdbd0453cdc8d4bbf68ab7c50917d
https://doi.org/10.1002/jps.2600561016
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