Analysis of Dosing Regimen and Reproducibility of Intraspinal Grafting of Human Spinal Stem Cells in Immunosuppressed Minipigs

Autor: Dusan Usvald, Peter Vodicka, Jana Hlucilova, Radek Prochazka, Jan Motlik, Karolina Kuchorova, Karl Johe, Silvia Marsala, Miriam Scadeng, Osamu Kakinohana, Roman Navarro, Marian Santa, Michael P. Hefferan, Tony L. Yaksh, Martin Marsala

Publikováno v: Cell Transplantation, Vol 19 (2010)

In recent studies using a rat aortic balloon occlusion model, we have demonstrated that spinal grafting of rat or human neuronal precursors or human postmitotic hNT neurons leads to progressive amelioration of spasticity and rigidity and correspondin

Externí odkaz: https://doaj.org/article/9502efaf0c1341d68db7fac66301b1ba

Amelioration of Both Central and Peripheral Neuropathy in Mouse Models of Type 1 and Type 2 Diabetes by the Neurogenic Molecule NSI-189

Autor: Betelhem Kifle, Lucy Guernsey, David M. Quach, Darrel R Smith, Karl Johe, Paul Fernyhough, Nigel A. Calcutt, Corinne G. Jolivalt, Alexandra Marquez, Gabriela Sanchez, Michael P. Hefferan, Carlos J. Anaya, Nabeel Muttalib, Michelle C Navarro Diaz

Publikováno v: Diabetes, vol 68, iss 11
Diabetes

While peripheral neuropathy is the most common complication of long-term diabetes, cognitive deficits associated with encephalopathy and myelopathy also occur. Diabetes is a risk factor for Alzheimer disease (AD) and increases the risk of progression

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8926a1dc93e8989576f04dd2967b841b
https://escholarship.org/uc/item/8xs9k5d6

Remediation of Radiation-Induced Cognitive Dysfunction through Oral Administration of the Neuroprotective Compound NSI-189

Autor: Celine Lu, Charles L. Limoli, Karl Johe, Erich Giedzinski, Barrett D. Allen, Michael P. Hefferan, Munjal M. Acharya, David M. Quach, Nicole N. Chmielewski

Publikováno v: Radiation research, vol 189, iss 4
Allen, BD; Acharya, MM; Lu, C; Giedzinski, E; Chmielewski, NN; Quach, D; et al.(2018). Remediation of Radiation-Induced Cognitive Dysfunction through Oral Administration of the Neuroprotective Compound NSI-189. RADIATION RESEARCH, 189(4), 345-353. doi: 10.1667/RR14879.1. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/5338134h

Clinical management of primary and secondary central nervous system (CNS) malignancies frequently includes radiotherapy to forestall tumor growth and recurrence after surgical resection. While cranial radiotherapy remains beneficial, adult and pediat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ae18c424c729e231896dc2f02f52239
https://escholarship.org/uc/item/5338134h

Effective long-term immunosuppression in rats by subcutaneously implanted sustained-release tacrolimus pellet: Effect on spinally grafted human neural precursor survival

Autor: Danielle Goldberg, Kazuhiko Yamada, Sebastiaan van Gorp, Silvia Marsala, Marian Hruska-Plochan, Stefan Juhas, Marjolein Leerink, František Rypáček, Nadezda Lukacova, Martin Marsala, Juraj Ševc, Jana Juhasova, Michael P. Hefferan, Jack D. Bui, Karl Johe, Camila Santucci, Ludka Machova, Osamu Kakinohana, Jan Motlik

Publikováno v: Experimental Neurology, 248, 85-99. Elsevier Science

Achievement of effective, safe and long-term immunosuppression represents one of the challenges in experimental allogeneic and xenogeneic cell and organ transplantation. The goal of the present study was to develop a reliable, long-term immunosuppres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4d9ea7cc2aec14510db3ac3fb9dcee3
https://doi.org/10.1016/j.expneurol.2013.05.017

Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells

Autor: Sol M. Reyna, Francesca S. Boscolo, Louise C. Laurent, Anne M. Remes, Sebastiaan van Gorp, Edward H. Koo, Shauna H. Yuan, Lawrence S.B. Goldstein, Michael P. Hefferan, Fred H. Gage, Yangling Mu, Kristopher L. Nazor, Christian T. Carson, Cheryl Herrera, Martin Marsala, Mason A. Israel, Cedric Bardy

Publikováno v: Nature, vol 482, iss 7384
Nature
Nature, 482(7384), 216-U107. Nature Publishing Group

Our understanding of Alzheimer's disease pathogenesis is currently limited by difficulties in obtaining live neurons from patients and the inability to model the sporadic form of the disease. It may be possible to overcome these challenges by reprogr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a3617eda8a5a98af794ec45819b01e
https://cris.maastrichtuniversity.nl/en/publications/e4430046-ba7d-4be8-8f05-4f841ba7f10a