Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Michael P. Groziak"'
Autor:
Michael P. Groziak, Ronghui Lin
Publikováno v:
ARKIVOC, Vol 2000, Iss 1, Pp 25-36 (2000)
Externí odkaz:
https://doaj.org/article/f18addd85fee4a53b970a6a9557e60b9
Publikováno v:
Bioorganicmedicinal chemistry letters. 72
To further the development of boron heterocyclic compounds that are useful to medicinal chemistry, we demonstrate how the class of compounds known as the diazaborines can be elaborated to produce an exceptionally close structural mimic of a natural e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8be67ac9e9b950696bbd711df623a7fe
https://pubmed.ncbi.nlm.nih.gov/35738349
https://pubmed.ncbi.nlm.nih.gov/35738349
Publikováno v:
Journal of Heterocyclic Chemistry. 56:2960-2965
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::760155a045bb3e1dc798f40d01296081
https://doi.org/10.1002/jhet.3651
https://doi.org/10.1002/jhet.3651
Publikováno v:
Journal of Heterocyclic Chemistry. 54:749-752
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e3fdd76a0388ff2cc94c1304c09a92d3
https://doi.org/10.1002/jhet.2608
https://doi.org/10.1002/jhet.2608
Autor:
H. Howard Xu, Damian H. Gilling, Cheryl A. Jordan, Michael P. Groziak, Jessica L. Vey, Mkrtich V. Serobyan, Braddock A. Sandoval
Publikováno v:
Acta Crystallographica Section F Structural Biology Communications. 71:1521-1530
Enoyl-ACP reductase, the last enzyme of the fatty-acid biosynthetic pathway, is the molecular target for several successful antibiotics such as the tuberculosis therapeutic isoniazid. It is currently under investigation as a narrow-spectrum antibioti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9fd927aed6db997e7d21bab761ceef2
https://doi.org/10.1107/s2053230x15022098
https://doi.org/10.1107/s2053230x15022098
Autor:
Lance Roppiyakuda, Isba Silva, Divya Kanichar, Shakila Rahman, Feimeng Zhou, Jeanie M. Garcia, Ewa Kosmowska, Walfre Martinez, Jameka Jefferson, Felicia Chow, Matthew S. Ward, Michael P. Groziak, Elena Buglo, Kim P. Tran, Michelle Faust, H. Howard Xu
Publikováno v:
Bioorganicmedicinal chemistry. 24(15)
One of the hurdles in the discovery of antibiotics is the difficulty of linking antibacterial compounds to their cellular targets. Our laboratory has employed a genome-wide approach of over-expressing essential genes in order to identify cellular tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93e6ee2b1d70553d64eec93aa9135da9
https://pubmed.ncbi.nlm.nih.gov/27301675
https://pubmed.ncbi.nlm.nih.gov/27301675
Autor:
Michael P. Groziak, Brian J. Wang
The utility of boron-containing compounds extends beyond the well-known applications of boronic acids and esters in Suzuki cross-couplings and enzyme inhibition. In this selective review, the last 15 years' worth of advances in the synthesis and util
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f35539437df309bc8b52bcfcbe6560f3
https://doi.org/10.1016/bs.aihch.2015.10.002
https://doi.org/10.1016/bs.aihch.2015.10.002
Publikováno v:
Acta crystallographica. Section C, Structural chemistry. 71(Pt 12)
2-Acylated 2,3,1-benzodiazaborines can display unusual structures and reactivities. The crystal structure analysis of the boron heterocycle obtained by condensing 2-formylphenylboronic acid and picolinohydrazide reveals it to be an N→B-chelated zwi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30751932bab3b0fea86b05aa40c97b6f
https://pubmed.ncbi.nlm.nih.gov/26632836
https://pubmed.ncbi.nlm.nih.gov/26632836
Publikováno v:
Acta Crystallographica Section C Crystal Structure Communications. 69:183-185
The structure of the title compound, C7H6BNO3, a new boron heterocycle, prepared by the condensation of (2-ethoxycarbonylphenyl)boronic acid and hydroxylamine, reveals the specific mode of intramolecular condensation between a phenylboronic acid and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d54729f36b8e70fdbcb062a4683bb908
https://doi.org/10.1107/s0108270113000681
https://doi.org/10.1107/s0108270113000681
Autor:
Michael P. Groziak, David W. Thomas
Publikováno v:
The Journal of Organic Chemistry. 67:2152-2159
A new motif for restricting 5'-nucleotides to highly biologically relevant conformations has been developed. The 5',6-oxomethylene transglycosidically tethered versions of uridine 5'-monophosphate and 2'-deoxyuridine 5'-monophosphate (1 and 2, respec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b1b4863f726c3de7070979f3e488529
https://doi.org/10.1021/jo0110045
https://doi.org/10.1021/jo0110045