Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Michael P. Geaghan"'
Autor:
Behnaz Khavari, Michelle M. Barnett, Ebrahim Mahmoudi, Michael P. Geaghan, Adam Graham, Murray J. Cairns
Publikováno v:
Life, Vol 14, Iss 5, p 562 (2024)
Oxidative stress is one of the most important environmental exposures associated with psychiatric disorders, but the underlying molecular mechanisms remain to be elucidated. In a previous study, we observed a substantial alteration of the gene expres
Externí odkaz:
https://doaj.org/article/8067494e375d48fa9d286adefe0c8708
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Susceptibility to pneumonia has a genetic component, but specific genes involved remain poorly understood. In this study, genetic signals associated with pneumonia susceptibility are identified, providing information about disease biology and potenti
Externí odkaz:
https://doaj.org/article/b1b60a51cd964f04b60d6c7905cc9091
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 23, p 9182 (2020)
Prenatal environmental exposures that have been shown to induce oxidative stress (OS) during pregnancy, such as smoking and alcohol consumption, are risk factors for the onset of schizophrenia and other neurodevelopmental disorders (NDDs). While the
Externí odkaz:
https://doaj.org/article/29db048482424a619e86c5fb14a082e3
Publikováno v:
Cells, Vol 9, Iss 4, p 1014 (2020)
MicroRNA (miRNA) coordinate complex gene expression networks in cells that are vital to support highly specialised morphology and cytoarchitecture. Neurons express a rich array of miRNA, including many that are specific or enriched, which have import
Externí odkaz:
https://doaj.org/article/8adb7eaccda74e61bc07eb3a7de2da23
Autor:
William R Reay, Sahar I El Shair, Michael P Geaghan, Carlos Riveros, Elizabeth G Holliday, Mark A McEvoy, Stephen Hancock, Roseanne Peel, Rodney J Scott, John R Attia, Murray J Cairns
Publikováno v:
eLife, Vol 10 (2021)
Measures of lung function are heritable, and thus, we sought to utilise genetics to propose drug-repurposing candidates that could improve respiratory outcomes. Lung function measures were found to be genetically correlated with seven druggable bioch
Externí odkaz:
https://doaj.org/article/16e00623321540a6a30d5172abea081f
Publikováno v:
Human Mutation. 43:2153-2169
Psychiatric disorders and other complex traits have a polygenic architecture, often associated with dozens or even hundreds of independent genomic loci. As each of these have a relatively small influence on the trait, the dissection of their biologic
Autor:
William R. Reay, Michael P. Geaghan, Joshua R. Atkins, Vaughan J. Carr, Melissa J. Green, Murray J. Cairns
Publikováno v:
The American Journal of Human Genetics. 109:1620-1637
Genetically informed drug development and repurposing is an attractive prospect for improving patient outcomes in psychiatry; however, the effectiveness of these endeavors is confounded by heterogeneity. We propose an approach that links intervention
Autor:
William R. Reay, Dylan J. Kiltschewskij, Michael P. Geaghan, Joshua R. Atkins, Vaughan J. Carr, Melissa J. Green, Murray J. Cairns
Publikováno v:
Science Advances. 8
There is a long-standing interest in exploring the relationship between blood-based biomarkers and psychiatric disorders, despite their causal role being difficult to resolve in observational studies. In this study, we leverage genome-wide associatio
Autor:
William R Reay, Michael P Geaghan, Joshua Ronald Atkins, Vaughan J Carr, Melissa J Green, Murray J Cairns
Genetically informed drug development and repurposing is an attractive prospect for improving outcomes in patients with psychiatric illness; however, the effectiveness of these endeavours can be confounded by heterogeneity. In this study, we propose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b5de6fd4b927d0fca8744b796798168d
https://doi.org/10.1101/2022.03.20.22272666
https://doi.org/10.1101/2022.03.20.22272666
Publikováno v:
Neuropsychopharmacology
Data from observational studies have suggested an involvement of abnormal glycaemic regulation in the pathophysiology of psychiatric illness. This may be an attractive target for clinical intervention as glycaemia can be modulated by both lifestyle f