Zobrazeno 1 - 10
of 113
pro vyhledávání: '"Michael P. Gantier"'
Autor:
Tomalika R. Ullah, Matt D. Johansen, Katherine R. Balka, Rebecca L. Ambrose, Linden J. Gearing, James Roest, Julian P. Vivian, Sunil Sapkota, W. Samantha N. Jayasekara, Daniel S. Wenholz, Vina R. Aldilla, Jun Zeng, Stefan Miemczyk, Duc H. Nguyen, Nicole G. Hansbro, Rajan Venkatraman, Jung Hee Kang, Ee Shan Pang, Belinda J. Thomas, Arwaf S. Alharbi, Refaya Rezwan, Meredith O’Keeffe, William A. Donald, Julia I. Ellyard, Wilson Wong, Naresh Kumar, Benjamin T. Kile, Carola G. Vinuesa, Graham E. Kelly, Olivier F. Laczka, Philip M. Hansbro, Dominic De Nardo, Michael P. Gantier
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract TANK-binding kinase 1 (TBK1) is a key signalling component in the production of type-I interferons, which have essential antiviral activities, including against SARS-CoV-2. TBK1, and its homologue IκB kinase-ε (IKKε), can also induce pro-
Externí odkaz:
https://doaj.org/article/780fdb67fa074e35823aa88357231e9d
Autor:
Marion C. Bichet, Jack Adderley, Laura Avellaneda-Franco, Isabelle Magnin-Bougma, Natasha Torriero-Smith, Linden J. Gearing, Celine Deffrasnes, Cassandra David, Genevieve Pepin, Michael P. Gantier, Ruby CY Lin, Ruzeen Patwa, Gregory W. Moseley, Christian Doerig, Jeremy J. Barr
Publikováno v:
PLoS Biology, Vol 21, Iss 10 (2023)
Externí odkaz:
https://doaj.org/article/87a7aefbd0b44585970f3caf63888312
Autor:
Annemarie Steiner, Katja Hrovat-Schaale, Ignazia Prigione, Chien-Hsiung Yu, Pawat Laohamonthonkul, Cassandra R. Harapas, Ronnie Ren Jie Low, Dominic De Nardo, Laura F. Dagley, Michael J. Mlodzianoski, Kelly L. Rogers, Thomas Zillinger, Gunther Hartmann, Michael P. Gantier, Marco Gattorno, Matthias Geyer, Stefano Volpi, Sophia Davidson, Seth L. Masters
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Mutations in the coatomer complex I can result in endoplasmic reticulum stress and inflammatory consequences. Here authors define aberrant activation of the STING immunosensing pathway in a disturbed coatmer complex context and the therapeutic modula
Externí odkaz:
https://doaj.org/article/30fa6bbd687e41a1bd2b9d85bd46d601
Autor:
Tomalika R. Ullah, Katherine R. Balka, Rebecca L. Ambrose, Geneviève Pépin, Matthew C. J. Wilce, Jacqueline A. Wilce, Belinda J. Thomas, Dominic De Nardo, Bryan R. G. Williams, Michael P. Gantier
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Cytoplasmic detection of DNA by cyclic GMP-AMP (cGAMP) synthase (cGAS) is an essential component of antiviral responses. Upon synthesis, cGAMP binds to the stimulator of interferon (IFN) genes (STING) in infected and adjacent cells through i
Externí odkaz:
https://doaj.org/article/a0404e892695413e816c5388d17e47d4
Autor:
Mihiri Goonetilleke, Nathan Kuk, Jeanne Correia, Alex Hodge, Gregory Moore, Michael P. Gantier, George Yeoh, William Sievert, Rebecca Lim
Publikováno v:
Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-13 (2021)
Abstract Background Non-alcoholic fatty liver disease is the most common liver disease globally and in its inflammatory form, non-alcoholic steatohepatitis (NASH), can progress to cirrhosis and hepatocellular carcinoma (HCC). Currently, patient educa
Externí odkaz:
https://doaj.org/article/e6d6b91ca0be446bbc2ca67bfcc4f68e
Autor:
Pacôme B. Prompsy, John Toubia, Linden J. Gearing, Randle L. Knight, Samuel C. Forster, Cameron P. Bracken, Michael P. Gantier
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 4896-4903 (2021)
microRNAs (miRNAs) are important modulators of messenger RNA stability and translation, controlling wide gene networks. Albeit generally modest on individual targets, the regulatory effect of miRNAs translates into meaningful pathway modulation throu
Externí odkaz:
https://doaj.org/article/7b91726759744c218543e3f0c73fa62e
Autor:
Sumaiah S. Al-Asmari, Aleksandra Rajapakse, Tomalika R. Ullah, Geneviève Pépin, Laura V. Croft, Michael P. Gantier
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2022)
Activation of the STING pathway upon genotoxic treatment of cancer cells has been shown to lead to anti-tumoral effects, mediated through the acute production of interferon (IFN)-β. Conversely, the pathway also correlates with the expression of NF-
Externí odkaz:
https://doaj.org/article/2a4a16aedce0440b89b22d6b461ad654
Autor:
Geneviève Pépin, Dominic De Nardo, Christina L. Rootes, Tomalika R. Ullah, Sumaiah S. Al-Asmari, Katherine R. Balka, Hong-Mei Li, Kylie M. Quinn, Fiona Moghaddas, Stephane Chappaz, Benjamin T. Kile, Eric F. Morand, Seth L. Masters, Cameron R. Stewart, Bryan R. G. Williams, Michael P. Gantier
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT Activation of cyclic GMP-AMP (cGAMP) synthase (cGAS) plays a critical role in antiviral responses to many DNA viruses. Sensing of cytosolic DNA by cGAS results in synthesis of the endogenous second messenger cGAMP that activates stimulator o
Externí odkaz:
https://doaj.org/article/cbfc430aefe94522b1b1208699100db7
Autor:
Kathi Zarnack, Sureshkumar Balasubramanian, Michael P. Gantier, Vladislav Kunetsky, Michael Kracht, M. Lienhard Schmitz, Katja Sträßer
Publikováno v:
Biomolecules, Vol 10, Iss 9, p 1310 (2020)
Signal transduction and the regulation of gene expression are fundamental processes in every cell. RNA-binding proteins (RBPs) play a key role in the post-transcriptional modulation of gene expression in response to both internal and external stimuli
Externí odkaz:
https://doaj.org/article/8a4369959d984890b0139c73c648f7ce
Autor:
Le Ying, Feng Yan, Qiaohong Meng, Liang Yu, Xiangliang Yuan, Michael P. Gantier, Bryan R. G. Williams, David W. Chan, Liyun Shi, Yugang Tu, Peihua Ni, Xuefeng Wang, Weisan Chen, Xingxing Zang, Dakang Xu, Yiqun Hu
Publikováno v:
OncoImmunology, Vol 7, Iss 6 (2018)
Current studies aiming at identifying single immune markers with prognostic value have limitations in the context of complex antitumor immunity and cancer immune evasion. Here, we show how the integration of several immune markers influences the pred
Externí odkaz:
https://doaj.org/article/48a37ec8b9c0424f9bd94b54ceff7cf4