Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Michael P. Gamcsik"'
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract Tumor tissue contains a continuous distribution of static and dynamically changing oxygen environments with levels ranging from physiologically normal oxygen down to anoxia. However, in vitro studies are often performed under oxygen levels t
Externí odkaz:
https://doaj.org/article/9b8ffc8ada3e4cc39c4da97b11ed98ed
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 4733 (2022)
Nuclear magnetic resonance (NMR) spectroscopy was used to monitor glutathione metabolism in alginate-encapsulated JM-1 hepatoma cells perfused with growth media containing [3,3′-13C2]-cystine. After 20 h of perfusion with labeled medium, the 13C NM
Externí odkaz:
https://doaj.org/article/a58cbe70233045228bd3862c9aa63e0e
Autor:
Allyson L. Mellinger, Russell R. Kibbe, Zahid N. Rabbani, Danielle Meritet, David C. Muddiman, Michael P. Gamcsik
Publikováno v:
Free Radical Biology and Medicine. 193:677-684
Although glutathione plays a key role in cancer cell viability and therapy response there is no clear trend in relating the level of this antioxidant to clinical stage, histological grade, or therapy response in patient tumors. The likely reason is t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac4b49902374c09f8f10e0071f1015be
https://doi.org/10.1016/j.freeradbiomed.2022.11.010
https://doi.org/10.1016/j.freeradbiomed.2022.11.010
Publikováno v:
Journal of Proteome Research. 21:1800-1807
Most mass spectrometry imaging (MSI) methods provide a molecular map of tissue content but little information on tissue function. Mapping tissue function is possible using several well-known examples of "functional imaging" such as positron emission
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d222b235117459b2a186b8e9d4dde2
https://doi.org/10.1021/acs.jproteome.2c00220
https://doi.org/10.1021/acs.jproteome.2c00220
Publikováno v:
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Tumor tissue contains a continuous distribution of static and dynamically changing oxygen environments with levels ranging from physiologically normal oxygen down to anoxia. However, in vitro studies are often performed under oxygen levels that are f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06e09c22c8d9fd340e7b2873876b7d74
https://pubmed.ncbi.nlm.nih.gov/33597640
https://pubmed.ncbi.nlm.nih.gov/33597640
Autor:
Zahid N. Rabbani, Tyler Sattler, Ming Yao, Glenn M. Walker, David A. Zaharoff, Michael P. Gamcsik, Khue G. Nguyen
Publikováno v:
Anal Chem
Detecting the effects of low oxygen on cell function is often dependent on monitoring the expression of a number of hypoxia markers. The time dependence of the appearance and stability of these markers varies between cell lines. Assessing cellular ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6df3491ffe0c6fad433fcd282ec3591
https://pubmed.ncbi.nlm.nih.gov/31694368
https://pubmed.ncbi.nlm.nih.gov/31694368
Autor:
Zahid N. Rabbani, Ming Yao, Glenn M. Walker, Thomas Pulliam, Tyler Sattler, Michael P. Gamcsik
Precise oxygen control is critical to evaluating cell growth, molecular content, and stress response in cultured cells. We have designed, fabricated, and characterized a 96-well plate-based device that is capable of delivering eight static or dynamic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a4e216c52b2cbb99ebec97a36eed892
https://europepmc.org/articles/PMC6293053/
https://europepmc.org/articles/PMC6293053/
Autor:
Peter E. Thelwall, Matthew Clemence, John T. Skamarauskas, Fiona Oakley, Michael Dunn, Fiona E. Smith, Carlo Bawn, Daniel S. Vidler, Peter G. Blain, Roy Taylor, Michael P. Gamcsik
Publikováno v:
Hepatology (Baltimore, Md.)
UNLABELLED: Oxidative stress (OS) plays a central role in the progression of liver disease and in damage to liver by toxic xenobiotics. We have developed methods for noninvasive assessment of hepatic OS defenses by measuring flux through the glutathi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3fedfb2a7fd85044be4964bbe104881
http://europepmc.org/articles/PMC4160151
http://europepmc.org/articles/PMC4160151
Autor:
M. Daniel Clark, Roxana Pourdeyhimi, Peter E. Thelwall, Zahid N. Rabbani, Michael P. Gamcsik, Jeffrey M. Macdonald, Stephen J. Blackband, Nicholas E. Simpson
Publikováno v:
NMR in Biomedicine. 25:271-278
The metabolism of glycine into glutathione was monitored noninvasively in vivo in intact rat mammary adenocarcinomas (R3230Ac) by MRI and MRS. Metabolism was tracked by following the isotope label from intravenously infused [2-13C]-glycine into the g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7eb85549ef68aff2d627c1be251673a2
https://doi.org/10.1002/nbm.1745
https://doi.org/10.1002/nbm.1745
Autor:
Michael P. Gamcsik, Rebecca L. Mutesi, Michael A. D'Alessandro, James B. Springer, Prince N. A. Amoyaw, Collin R. Dempsey, Susan M. Ludeman
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 54:607-612
Effects of neurodegeneration have been linked to inefficient detoxification of free radicals due to lowered concentrations of antioxidants, especially glutathione, in the brain. In the biosynthesis of glutathione, cysteine concentration is generally
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::42adbdc33a51bc82b545db05dfa3833d
https://doi.org/10.1002/jlcr.1904
https://doi.org/10.1002/jlcr.1904