Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Michael P Verzi"'
Autor:
Badi Sri Sailaja, Sohaib Hassan, Evan Cohen, Irina Tmenova, Renalison Farias-Pereira, Michael P Verzi, Ilya Raskin
Publikováno v:
PLoS ONE, Vol 17, Iss 12, p e0279370 (2022)
This study aims to investigate the anti-inflammatory effects of moringa isothiocyanate-1 (MIC-1) extracted from seeds of Moringa oleifera Lam. in lipopolysaccharide (LPS)-induced inflammation models. MIC-1 decreased nitric oxide production and reduce
Externí odkaz:
https://doaj.org/article/113107c9e059408eb5ab5cc040630812
Publikováno v:
PLoS ONE, Vol 16, Iss 4, p e0248691 (2021)
This study aims to document the dual mode of pharmacological action of moringa isothiocyanate-1 (MIC-1) derived from seeds of Moringa oleifera Lam. Oral administration of chemically stable MIC-1 (80 mg/kg) significantly reduced the expression of infl
Externí odkaz:
https://doaj.org/article/e68835a7420d42aeb2b84afb0938afd8
Autor:
Youjin Kim, Alex G Wu, Asha Jaja-Chimedza, Brittany L Graf, Carrie Waterman, Michael P Verzi, Ilya Raskin
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0184709 (2017)
Moringa (Moringa oleifera Lam.) seed extract (MSE) has anti-inflammatory and antioxidant activities. We investigated the effects of MSE enriched in moringa isothiocyanate-1 (MIC-1), its putative bioactive, on ulcerative colitis (UC) and its anti-infl
Externí odkaz:
https://doaj.org/article/c528e0487a7148acbcd46bcadf9e5075
Autor:
Wei Gu, Xiaofeng Huang, Pratik N. P. Singh, Sanlan Li, Ying Lan, Min Deng, Lauretta A. Lacko, Jesus M. Gomez-Salinero, Shahin Rafii, Michael P. Verzi, Ramesh A. Shivdasani, Qiao Zhou
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Plasticity among cell lineages is a fundamental, but poorly understood, property of regenerative tissues. In the gut tube, the small intestine absorbs nutrients, whereas the colon absorbs electrolytes. In a striking display of inherent plast
Externí odkaz:
https://doaj.org/article/040c31972788465f824261ca65f6d92f
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114242- (2024)
Summary: Terminal differentiation requires massive restructuring of the transcriptome. During intestinal differentiation, the expression patterns of nearly 4,000 genes are altered as cells transition from progenitor cells in crypts to differentiated
Externí odkaz:
https://doaj.org/article/078092799319444eb70df872f85604f0
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
Hepatocyte nuclear factor 4-alpha (HNF4α) drives a complex array of transcriptional programs across multiple organs. Beyond its previously documented function in the liver, HNF4α has crucial roles in the kidney, intestine, and pancreas. In the inte
Externí odkaz:
https://doaj.org/article/434b08188b394b8eacde64dfceefd807
Autor:
Charlie J. Childs, Emily M. Holloway, Caden W. Sweet, Yu-Hwai Tsai, Angeline Wu, Abigail Vallie, Madeline K. Eiken, Meghan M. Capeling, Rachel K. Zwick, Brisa Palikuqi, Coralie Trentesaux, Joshua H. Wu, Oscar Pellón-Cardenas, Charles J. Zhang, Ian Glass, Claudia Loebel, Qianhui Yu, J. Gray Camp, Jonathan Z. Sexton, Ophir D. Klein, Michael P. Verzi, Jason R. Spence
Publikováno v:
JCI Insight, Vol 8, Iss 6 (2023)
Epithelial organoids derived from intestinal tissue, called enteroids, recapitulate many aspects of the organ in vitro and can be used for biological discovery, personalized medicine, and drug development. Here, we interrogated the cell signaling env
Externí odkaz:
https://doaj.org/article/55a6984dd35845d1b85d5c97f50bf6ee
Autor:
Kevin Tong, Oscar Pellón-Cárdenas, Veerin R. Sirihorachai, Bailey N. Warder, Om A. Kothari, Ansu O. Perekatt, Emily E. Fokas, Robert L. Fullem, Anbo Zhou, Joshua K. Thackray, Hiep Tran, Lanjing Zhang, Jinchuan Xing, Michael P. Verzi
Publikováno v:
Cell Reports, Vol 21, Iss 13, Pp 3833-3845 (2017)
Oncogenic mutations in BRAF are believed to initiate serrated colorectal cancers; however, the mechanisms of BRAF-driven colon cancer are unclear. We find that oncogenic BRAF paradoxically suppresses stem cell renewal and instead promotes differentia
Externí odkaz:
https://doaj.org/article/012715f62d1c4a9eb89f470d4fb955d6
Autor:
Steven K. Libutti, Sharon R. Pine, Michael P. Verzi, Zhongren Zhou, Parisa Javidian, Asha Adem, Jean Arly Volmar, Peter Auteri, Nicholas Nolan, Genesaret Rubio, Mijung Kwon
Aneuploid mucinous colorectal adenocarcinoma (MAC) is an aggressive subtype of colorectal cancer with poor prognosis. The tumorigenic mechanisms in aneuploid MAC are currently unknown. Here we show that downregulation of Filamin A–interacting prote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77b6dc9e259b8518d2220ca1a8e5d01b
https://doi.org/10.1158/0008-5472.c.6547843.v1
https://doi.org/10.1158/0008-5472.c.6547843.v1
Autor:
Steven K. Libutti, Sharon R. Pine, Michael P. Verzi, Zhongren Zhou, Parisa Javidian, Asha Adem, Jean Arly Volmar, Peter Auteri, Nicholas Nolan, Genesaret Rubio, Mijung Kwon
8 Supplementary figures and 1 Supplementary info.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa31bf73327abd87246ea96d82f3b652
https://doi.org/10.1158/0008-5472.22535380.v1
https://doi.org/10.1158/0008-5472.22535380.v1