Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Michael P Rosconi"'
Autor:
Adrianna Latuszek, Yashu Liu, Olav Olsen, Randi Foster, Marc Cao, Irena Lovric, Ming Yuan, Nina Liu, Henry Chen, Qian Zhang, Hui Xiao, Carola Springer, George Ehrlich, Vishal Kamat, Ashique Rafique, Ying Hu, Pamela Krueger, Tammy Huang, William Poueymirou, Robert Babb, Michael P Rosconi, Marc W Retter, Gang Chen, Lori Morton, Brian Zambrowicz, Jingtai Cao, Carmelo Romano, William C Olson
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0231892 (2020)
Complement is a key component of the innate immune system. Inappropriate complement activation underlies the pathophysiology of a variety of diseases. Complement component 5 (C5) is a validated therapeutic target for complement-mediated diseases, but
Externí odkaz:
https://doaj.org/article/050c7eb8e3d948eab37777fb62eda2e6
Autor:
Sophia Liu, Yuetian Yan, Cody M. Secor, Zachary R. Oberholtzer, Donna J. Skow, Mushhood Sheikh, Youmi Moon, Yue Fu, Cristinel Sandu, Shunhai Wang, Ning Li, Jennifer B. Nguyen, Michael P. Rosconi, Erica A. Pyles
Publikováno v:
mAbs, Vol 16, Iss 1 (2024)
ABSTRACTCo-formulation of multiple drug products is an efficient and convenient approach to simultaneously deliver multiple biotherapeutics with the potentially added benefit of a synergistic therapeutic effect. However, co-formulation also increases
Externí odkaz:
https://doaj.org/article/1494bc863c804d3eb9523d2ed2f12fcb
Autor:
Zhijie Wu, Hongxia Wang, Jikang Wu, Yu Huang, Xueqing Zhao, Jennifer B. Nguyen, Michael P. Rosconi, Erica A. Pyles, Haibo Qiu, Ning Li
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 223:115147
Therapeutic antibodies are a major class of pharmaceutical drugs used to treat a wide variety of diseases. They have several advantages including the high specificity and binding affinity to their molecular targets, and generally low immunotoxicity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28ce0ee8f42d9e9bf330a7323651028e
https://doi.org/10.1016/j.jpba.2022.115147
https://doi.org/10.1016/j.jpba.2022.115147
Autor:
Irena Lovric, Hui Xiao, Jingtai Cao, Brian Zambrowicz, Carola Springer, Olav Olsen, Vishal Kamat, Marc W. Retter, Ming Yuan, Ashique Rafique, Ying Hu, George Ehrlich, Yashu Liu, William C. Olson, Carmelo Romano, Randi Foster, Pamela Krueger, Nina Liu, Henry Chen, William Poueymirou, Qian Zhang, Michael P. Rosconi, Morton Lori C, Marc Cao, Gang Chen, Robert Babb, Adrianna Latuszek, Tammy T. Huang
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0231892 (2020)
PLoS ONE
PLoS ONE
Complement is a key component of the innate immune system. Inappropriate complement activation underlies the pathophysiology of a variety of diseases. Complement component 5 (C5) is a validated therapeutic target for complement-mediated diseases, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e67a14314ecd3b03b580d43c5072a1
https://doaj.org/article/050c7eb8e3d948eab37777fb62eda2e6
https://doaj.org/article/050c7eb8e3d948eab37777fb62eda2e6
Publikováno v:
Nature. 462:745-756
Ionotropic glutamate receptors mediate most excitatory neurotransmission in the central nervous system and function by opening a transmembrane ion channel upon binding of glutamate. Despite their crucial role in neurobiology, the architecture and ato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b2df076d7b6dc6cd16de193926fdb23
https://doi.org/10.1038/nature08624
https://doi.org/10.1038/nature08624
Publikováno v:
Biochemistry. 45:8124-8134
After low pH-triggered membrane insertion, the T domain of diphtheria toxin helps translocate the catalytic domain of the toxin across membranes. In this study, the hydrophilic N-terminal helices of the T domain (TH1-TH3) were studied. The conformati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f14db1c1e8beb5e2da7186928db69188
https://doi.org/10.1021/bi060587f
https://doi.org/10.1021/bi060587f
Autor:
Michael P. Rosconi, Erwin London
Publikováno v:
Journal of Biological Chemistry. 277:16517-16527
The T domain of diphtheria toxin undergoes a low pH-induced conformational change that allows it to penetrate cell membranes. T domain hydrophobic helices 8 and 9 can adopt two conformations, one close to the membrane surface (P state) and a second i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2ffe5eae32a33960add3885fb95a842
https://doi.org/10.1074/jbc.m200442200
https://doi.org/10.1074/jbc.m200442200
Publikováno v:
Biopolymers. 49:29-40
There is currently a great deal of interest in the early events in protein folding. Two issues that have generated particular interest are the nature of the unfolded state under native conditions and the role of local interactions in folding. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::798285e203495f12342f1f1744ce0b80
https://doi.org/10.1002/(sici)1097-0282(199901)49:1<29::aid-bip4>3.0.co
https://doi.org/10.1002/(sici)1097-0282(199901)49:1<29::aid-bip4>3.0.co
Publikováno v:
Biochemistry. 43(28)
Low pH-induced membrane insertion by diphtheria toxin T domain is crucial for A chain translocation into the cytoplasm. To define the membrane topography of the T domain, the exposure of biotinylated Cys residues to the cis and trans bilayer surfaces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cad2a1b48643672b33c68e8c7627cd2a
https://pubmed.ncbi.nlm.nih.gov/15248770
https://pubmed.ncbi.nlm.nih.gov/15248770
Autor:
Nicholas J. Papadopoulos, Qin Ruan, George D. Yancopoulos, Michael P. Rosconi, Stanley J. Wiegand, Joel H. Martin, Ashique Rafique, Ergang Shi, Neil Stahl, Erica Pyles
Publikováno v:
Angiogenesis
Pharmacological inhibition of VEGF-A has proven to be effective in inhibiting angiogenesis and vascular leak associated with cancers and various eye diseases. However, little information is currently available on the binding kinetics and relative bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9dbeca5d15dd73a59108b6c5e264157