Control of acute myeloid leukemia and generation of immune memory in vivo using AMV564, a bivalent bispecific CD33 x CD3 T cell engager.

Autor: Linda G Eissenberg, Julie K Ritchey, Michael P Rettig, Dilan A Patel, Kiran Vij, Feng Gao, Victoria Smith, Tae H Han, John F DiPersio

Publikováno v: PLoS ONE, Vol 19, Iss 5, p e0300174 (2024)

Off-the-shelf immunotherapeutics that suppress tumor growth and provide durable protection against relapse could enhance cancer treatment. We report preclinical studies on a CD33 x CD3 bivalent bispecific diabody, AMV564, that not only suppresses tum

Externí odkaz: https://doaj.org/article/8c314f5537e44cf58287f597f11ec364

A long-acting interleukin-7, rhIL-7-hyFc, enhances CAR T cell expansion, persistence, and anti-tumor activity

Autor: Miriam Y. Kim, Reyka Jayasinghe, Jessica M. Devenport, Julie K. Ritchey, Michael P. Rettig, Julie O’Neal, Karl W. Staser, Krista M. Kennerly, Alun J. Carter, Feng Gao, Byung Ha Lee, Matthew L. Cooper, John F. DiPersio

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Chimeric antigen receptor T cells represent a breakthrough treatment in hematologic malignancies, but insufficient level of cytotoxicity and persistence of T cells might compromise success. Authors show here that a recombinant long acting form of int

Externí odkaz: https://doaj.org/article/57d87d554b9b4960b607af4e9bf488c8

Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury

Autor: Zhen Guo, Carla Valenzuela Ripoll, Antonino Picataggi, David R. Rawnsley, Mualla Ozcan, Julio A. Chirinos, Ezhilarasi Chendamarai, Amanda Girardi, Terrence Riehl, Hosannah Evie, Ahmed Diab, Attila Kovacs, Krzysztof Hyrc, Xiucui Ma, Aarti Asnani, Swapnil V. Shewale, Marielle Scherrer-Crosbie, Lauren Ashley Cowart, John S. Parks, Lei Zhao, David Gordon, Francisco Ramirez-Valle, Kenneth B. Margulies, Thomas P. Cappola, Ankit A. Desai, Lauren N. Pederson, Carmen Bergom, Nathan O. Stitziel, Michael P. Rettig, John F. DiPersio, Stefan Hajny, Christina Christoffersen, Abhinav Diwan, Ali Javaheri

Publikováno v: JACC Basic Transl Sci
Guo, Z, Valenzuela Ripoll, C, Picataggi, A, Rawnsley, D R, Ozcan, M, Chirinos, J A, Chendamarai, E, Girardi, A, Riehl, T, Evie, H, Diab, A, Kovacs, A, Hyrc, K, Ma, X, Asnani, A, Shewale, S V, Scherrer-Crosbie, M, Cowart, L A, Parks, J S, Zhao, L, Gordon, D, Ramirez-Valle, F, Margulies, K B, Cappola, T P, Desai, A A, Pedersen, L N, Bergom, C, Stitziel, N O, Rettig, M P, DiPersio, J F, Hajny, S, Christoffersen, C, Diwan, A & Javaheri, A 2023, ' Apolipoprotein M Attenuates Anthracycline Cardiotoxicity and Lysosomal Injury ', JACC: Basic to Translational Science, vol. 8, no. 3, pp. 340-355 . https://doi.org/10.1016/j.jacbts.2022.09.010

ObjectivesDetermine the role of apolipoprotein M (ApoM) in anthracycline (Dox) cardiotoxicity.BackgroundApoM binds the cardioprotective sphingolipid sphingosine-1-phosphate (S1P). Circulating ApoM is inversely associated with mortality in human heart

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0661923be6ea10183741312ef8961d2
https://doi.org/10.1016/j.jacbts.2022.09.010

Targeting CXCR4 in AML and ALL

Autor: Daniel Cancilla, Michael P. Rettig, John F. DiPersio

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

The interaction of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) blasts with the bone marrow microenvironment regulates self-renewal, growth signaling, as well as chemotherapy resistance. The chemokine receptor, CXC receptor 4 (

Externí odkaz: https://doaj.org/article/4abf6bc64764492391d8513edc68c0a1

Mobilized peripheral blood: an updated perspective [version 1; peer review: 2 approved]

Autor: Darja Karpova, Michael P. Rettig, John F. DiPersio

Publikováno v: F1000Research, Vol 8 (2019)

Enforced egress of hematopoietic stem cells (HSCs) out of the bone marrow (BM) into the peripheral circulation, termed mobilization, has come a long way since its discovery over four decades ago. Mobilization research continues to be driven by the ne

Externí odkaz: https://doaj.org/article/526b92ccbea1499dacd686fe7bd1b26d