Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Michael P Menden"'
Autor:
Dennis Wang, James Hensman, Ginte Kutkaite, Tzen S Toh, Ana Galhoz, GDSC Screening Team, Jonathan R Dry, Julio Saez-Rodriguez, Mathew J Garnett, Michael P Menden, Frank Dondelinger
Publikováno v:
eLife, Vol 9 (2020)
High-throughput testing of drugs across molecular-characterised cell lines can identify candidate treatments and discover biomarkers. However, the cells’ response to a drug is typically quantified by a summary statistic from a best-fit dose-respons
Externí odkaz:
https://doaj.org/article/51d4ac80e399452ea2ade47a41995bd5
Autor:
Juliane Tschuck, Vidya Padmanabhan Nair, Ana Galhoz, Carole Zaratiegui, Hin-Man Tai, Gabriele Ciceri, Ina Rothenaigner, Jason Tchieu, Brent R. Stockwell, Lorenz Studer, Daphne S. Cabianca, Michael P. Menden, Michelle Vincendeau, Kamyar Hadian
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract The development of functional neurons is a complex orchestration of multiple signaling pathways controlling cell proliferation and differentiation. Because the balance of antioxidants is important for neuronal survival and development, we hy
Externí odkaz:
https://doaj.org/article/444c8caf5d9e4924ae0ce2d1e59fd94d
Autor:
Irineos Papakyriacou, Ginte Kutkaite, Marta Rúbies Bedós, Divya Nagarajan, Liam P. Alford, Michael P. Menden, Yumeng Mao
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Immune checkpoint blockade therapy aims to activate the immune system to eliminate cancer cells. However, clinical benefits are only recorded in a subset of patients. Here, we leverage genome-wide CRISPR/Cas9 screens in a Tumor-Immune co-Cul
Externí odkaz:
https://doaj.org/article/b4b21ac099f0476298aa50b1eda1257e
Autor:
Michael P Menden, Francesco Iorio, Mathew Garnett, Ultan McDermott, Cyril H Benes, Pedro J Ballester, Julio Saez-Rodriguez
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61318 (2013)
Predicting the response of a specific cancer to a therapy is a major goal in modern oncology that should ultimately lead to a personalised treatment. High-throughput screenings of potentially active compounds against a panel of genomically heterogene
Externí odkaz:
https://doaj.org/article/762bb0ce04394c538ba05616548a9131
Autor:
Alexander J. Ohnmacht, Arndt Stahler, Sebastian Stintzing, Dominik P. Modest, Julian W. Holch, C. Benedikt Westphalen, Linus Hölzel, Marisa K. Schübel, Ana Galhoz, Ali Farnoud, Minhaz Ud-Dean, Ursula Vehling-Kaiser, Thomas Decker, Markus Moehler, Matthias Heinig, Volker Heinemann, Michael P. Menden
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Precision medicine has revolutionised cancer treatments; however, actionable biomarkers remain scarce. To address this, we develop the Oncology Biomarker Discovery (OncoBird) framework for analysing the molecular and biomarker landscape of r
Externí odkaz:
https://doaj.org/article/6154ff20ebe74724a6a6c7ebb50722a3
Autor:
Alexander Joschua Ohnmacht, Anantharamanan Rajamani, Göksu Avar, Ginte Kutkaite, Emanuel Gonçalves, Dieter Saur, Michael Patrick Menden
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Aberrant DNA methylation accompanies genetic alterations during oncogenesis and tumour homeostasis and contributes to the transcriptional deregulation of key signalling pathways in cancer. Despite increasing efforts in DNA methylation profil
Externí odkaz:
https://doaj.org/article/594ca880fb51453786dbe5a78deee1f9
Autor:
Peter Seiringer, Christina Hillig, Alexander Schäbitz, Manja Jargosch, Anna Caroline Pilz, Stefanie Eyerich, Andrea Szegedi, Michaela Sochorová, Florian Gruber, Christos C. Zouboulis, Tilo Biedermann, Michael P. Menden, Kilian Eyerich, Daniel Törőcsik
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Sebaceous glands drive acne, however, their role in other inflammatory skin diseases remains unclear. To shed light on their potential contribution to disease development, we investigated the spatial transcriptome of sebaceous glands in psoriasis and
Externí odkaz:
https://doaj.org/article/344dfef1bc99426eb7080f48d5482406
Autor:
Johanna Erber, Verena Kappler, Bernhard Haller, Hrvoje Mijočević, Ana Galhoz, Clarissa Prazeres da Costa, Friedemann Gebhardt, Natalia Graf, Dieter Hoffmann, Markus Thaler, Elke Lorenz, Hedwig Roggendorf, Florian Kohlmayer, Andreas Henkel, Michael P. Menden, Jürgen Ruland, Christoph D. Spinner, Ulrike Protzer, Percy Knolle, Paul Lingor
Publikováno v:
Emerging Infectious Diseases, Vol 28, Iss 3, Pp 572-581 (2022)
Hospital staff are at high risk for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during the coronavirus disease (COVID-19) pandemic. This cross-sectional study aimed to determine the prevalence of SARS-CoV-2 infection in hos
Externí odkaz:
https://doaj.org/article/792d43961682435ea3e32c7adb19a507
Autor:
Lucas Caldi Gomes, Ana Galhoz, Gaurav Jain, Anna‐Elisa Roser, Fabian Maass, Eleonora Carboni, Elisabeth Barski, Christof Lenz, Katja Lohmann, Christine Klein, Mathias Bähr, André Fischer, Michael P. Menden, Paul Lingor
Publikováno v:
Clinical and Translational Medicine, Vol 12, Iss 1, Pp n/a-n/a (2022)
Abstract Background Parkinson's disease (PD) is the second most common neurodegenerative disorder whose prevalence is rapidly increasing worldwide. The molecular mechanisms underpinning the pathophysiology of sporadic PD remain incompletely understoo
Externí odkaz:
https://doaj.org/article/c1c958499e774a69ba69e7f59eb3c227
Autor:
Ali Farnoud, Hesam Tofighian, Ingo Baumann, Kaveh Ahookhosh, Oveis Pourmehran, Xinguang Cui, Vincent Heuveline, Chen Song, Sarah Vreugde, Peter-John Wormald, Michael P. Menden, Otmar Schmid
Publikováno v:
Pharmaceuticals, Vol 16, Iss 1, p 81 (2023)
The nasal epithelium is an important target for drug delivery to the nose and secondary organs such as the brain via the olfactory bulb. For both topical and brain delivery, the targeting of specific nasal regions such as the olfactory epithelium (br
Externí odkaz:
https://doaj.org/article/dd6d42bdc9ec4f1fafb4fd066252f5aa