Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Michael P Lazaropoulos"'
Autor:
Andrew A. Gibb, Anh T. Huynh, Ryan B. Gaspar, Tori L. Ploesch, Alyssa A. Lombardi, Pawel K. Lorkiewicz, Michael P. Lazaropoulos, Ken Bedi, Zolt Arany, Kenneth B. Margulies, Bradford G. Hill, John W. Elrod
Publikováno v:
Journal of Molecular and Cellular Cardiology. 172:78-89
Fibrosis and extracellular matrix remodeling are mediated by resident cardiac fibroblasts (CFs). In response to injury, fibroblasts activate, differentiating into specialized synthetic and contractile myofibroblasts producing copious extracellular ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b078e2812f9c99cf4e925be5a0e1e138
https://doi.org/10.1016/j.yjmcc.2022.08.002
https://doi.org/10.1016/j.yjmcc.2022.08.002
Autor:
Lucy Lin, Mavis R. Swerdel, Michael P. Lazaropoulos, Gary S. Hoffman, Alana J. Toro-Ramos, Jennifer Wright, Howard Lederman, Jianmin Chen, Jennifer C. Moore, Ronald P. Hart
Publikováno v:
Stem Cell Reports, Vol 5, Iss 6, Pp 1097-1108 (2015)
A spontaneously reverted iPSC line was identified from an A-T subject with heterozygous ATM truncation mutations. The reverted iPSC line expressed ATM protein and was capable of radiation-induced phosphorylation of CHK2 and H2A.X. Genome-wide SNP ana
Externí odkaz:
https://doaj.org/article/94721fb9df1c44888e21a588cc88d000
Autor:
Maja Mustapic, Erez Eitan, John K. Werner, Sean T. Berkowitz, Michael P. Lazaropoulos, Joyce Tran, Edward J. Goetzl, Dimitrios Kapogiannis
Publikováno v:
Frontiers in Neuroscience, Vol 11 (2017)
Our team has been a pioneer in harvesting extracellular vesicles (EVs) enriched for neuronal origin from peripheral blood and using them as a biomarker discovery platform for neurological disorders. This methodology has demonstrated excellent diagnos
Externí odkaz:
https://doaj.org/article/ee52168c33b644afaf90186751583a68
Publikováno v:
Circ Res
Cardiac fibrosis is mediated by the activation of resident cardiac fibroblasts, which differentiate into myofibroblasts in response to injury or stress. Although myofibroblast formation is a physiological response to acute injury, such as myocardial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12797d550853611878dbae318144083e
https://doi.org/10.1161/circresaha.120.316958
https://doi.org/10.1161/circresaha.120.316958
Autor:
Michael P Lazaropoulos, John W Elrod
Publikováno v:
Curr Opin Physiol
Adverse cardiac remodeling is often precipitated by chronic stress or injury inflicted upon the heart during the progression of cardiovascular diseases. Mitochondria play an important role in the cardiomyocyte response to stress by serving as a signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9d367eec64aaa2eec13394d4678de77
https://europepmc.org/articles/PMC8903307/
https://europepmc.org/articles/PMC8903307/
Publikováno v:
Circulation. 142
A feature of heart failure (HF) is excessive extracellular matrix deposition and cardiac remodeling by a differentiated fibroblast population known as myofibroblasts. Identifying mechanisms of myofibroblast differentiation in cardiac fibrosis could y
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45227b06ee62799d53266139b7e37974
https://doi.org/10.1161/circ.142.suppl_3.15978
https://doi.org/10.1161/circ.142.suppl_3.15978
Autor:
John W. Elrod, Devin W. Kolmetzky, Andrew A. Gibb, Zolt Arany, Pawel Lorkiewicz, Michael P Lazaropoulos, Anh T Huynh, Kenneth B. Margulies, Alyssa A. Lombardi, Bradford G. Hill, Emma K Murray, Daniel P. Kelly
Publikováno v:
Circulation. 142
Cardiac fibrosis is mediated by the activation and differentiation of resident cardiac fibroblasts. While initially reparative, chronic activation leads to progressive cardiac dysfunction. Associated with myofibroblast formation are changes in metabo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::daa256b9c55b4df335724bbbd53b8cd3
https://doi.org/10.1161/circ.142.suppl_3.16406
https://doi.org/10.1161/circ.142.suppl_3.16406
Autor:
Joyce Tran, Chiung-Wei Huang, Sahil Chawla, Sean T. Berkowitz, Erez Eitan, Constantine G. Lyketsos, Maja Mustapić, Michael P. Lazaropoulos, Yang An, Ryan Spangler, Esther S. Oh, Luigi Ferrucci, Dimitrios Kapogiannis, Seema Gulyani, Susan M. Resnick, Michelle Shardell, Thomas C. Diehl, Edward J. Goetzl
Publikováno v:
JAMA Neurol
Importance Blood biomarkers able to diagnose Alzheimer disease (AD) at the preclinical stage would enable trial enrollment when the disease is potentially reversible. Plasma neuronal-enriched extracellular vesicles (nEVs) of patients with AD were rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a1a4c89dc13435e396d71b271d0e3b3
https://pubmed.ncbi.nlm.nih.gov/31305918
https://pubmed.ncbi.nlm.nih.gov/31305918
Autor:
Michael P. Lazaropoulos, Alana J. Toro-Ramos, Howard M. Lederman, Jianmin Chen, Jennifer C. Moore, Ronald P. Hart, Mavis R. Swerdel, Jennifer M. Wright, Lucy Lin, Gary S. Hoffman
Publikováno v:
Stem Cell Reports, Vol 5, Iss 6, Pp 1097-1108 (2015)
Stem Cell Reports
Stem Cell Reports
Summary A spontaneously reverted iPSC line was identified from an A-T subject with heterozygous ATM truncation mutations. The reverted iPSC line expressed ATM protein and was capable of radiation-induced phosphorylation of CHK2 and H2A.X. Genome-wide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d38e72fa143e337777946e9e018253b8
http://www.sciencedirect.com/science/article/pii/S2213671115003070
http://www.sciencedirect.com/science/article/pii/S2213671115003070
Publikováno v:
Circulation Research; 7/21/2023, Vol. 133 Issue 3, p252-254, 3p