Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Michael P Killoran"'
Autor:
Ce Shi, Michael P Killoran, Mary P Hall, Paul Otto, Monika G Wood, Ethan Strauss, Lance P Encell, Thomas Machleidt, Keith V Wood, Thomas A Kirkland
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0243747 (2020)
Firefly luciferase-based ATP detection assays are frequently used as a sensitive, cost-efficient method for monitoring hygiene in many industrial settings. Solutions of detection reagent, containing a mixture of a substrate and luciferase enzyme that
Externí odkaz:
https://doaj.org/article/4549be00272c490db5ba97c1d7c02863
Autor:
Ethan Edward Strauss, Paul Otto, Monika G. Wood, Mary P. Hall, Michael P Killoran, Lance P. Encell, Ce Shi, Thomas Machleidt, Keith V. Wood, Thomas A. Kirkland
Publikováno v:
PLoS ONE
PLoS ONE, Vol 15, Iss 12, p e0243747 (2020)
PLoS ONE, Vol 15, Iss 12, p e0243747 (2020)
Firefly luciferase-based ATP detection assays are frequently used as a sensitive, cost-efficient method for monitoring hygiene in many industrial settings. Solutions of detection reagent, containing a mixture of a substrate and luciferase enzyme that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ef2bf1e48d69be03ac6ff5852c2614a
https://pubmed.ncbi.nlm.nih.gov/33315907
https://pubmed.ncbi.nlm.nih.gov/33315907
Autor:
Matthew B. Robers, Ce Shi, Keith V. Wood, Kristopher Zimmerman, Marie K. Schwinn, James Robert Hartnett, Melanie Dart, Thomas Machleidt, Michael P Killoran, Emily Jost, Jennifer Wilkinson, Thomas A. Kirkland
Publikováno v:
ACS medicinal chemistry letters. 9(6)
Protein thermal shift assays (TSAs) provide a means for characterizing target engagement through ligand-induced thermal stabilization. Although these assays are widely utilized for screening libraries and validating hits in drug discovery programs, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc6ac143d89546b3bfee2252e1b9461
https://pubmed.ncbi.nlm.nih.gov/29937980
https://pubmed.ncbi.nlm.nih.gov/29937980
Autor:
Andrew F. Voter, James L. Keck, Gene E. Ananiev, Michael P. Killoran, Scott A. Wildman, F. Michael Hoffmann
Antibiotic-resistant bacterial infections are increasingly prevalent worldwide and there is an urgent need for novel classes of antibiotics capable of overcoming existing resistance mechanisms. One potential antibiotic target is the bacterial single-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f606b64ae6fbb3cc62d6dba8d45e6c7d
https://europepmc.org/articles/PMC5667550/
https://europepmc.org/articles/PMC5667550/
Publikováno v:
Molecular Microbiology. 71:158-171
Neisseria gonorrhoeae (Gc), an obligate human bacterial pathogen, utilizes pilin antigenic variation to evade host immune defenses. Antigenic variation is driven by recombination between expressed (pilE) and silent (pilS) copies of the pilin gene, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::008f8cf9cb08ce9284ffcaf48fe7c343
https://doi.org/10.1111/j.1365-2958.2008.06513.x
https://doi.org/10.1111/j.1365-2958.2008.06513.x
Autor:
Michael P. Killoran, James L. Keck
Publikováno v:
Nucleic Acids Research
RecQ helicases are critical for maintaining genome integrity in organisms ranging from bacteria to humans by participating in a complex network of DNA metabolic pathways. Their diverse cellular functions require specialization and coordination of mul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb8dd11374db3f46c71427db2c7397d
https://doi.org/10.1093/nar/gkn143
https://doi.org/10.1093/nar/gkn143
Autor:
Michael P. Killoran, James L. Keck
Publikováno v:
Nucleic Acids Research
Helicases are specialized molecular motors that separate duplex nucleic acids into single strands. The RecQ family of helicases functions at the interface of DNA replication, recombination and repair in bacterial and eukaryotic cells. They are key, m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88bebaf69e0f93483bb8ddc554800f4f
https://doi.org/10.1093/nar/gkl538
https://doi.org/10.1093/nar/gkl538
Autor:
Douglas A. Bernstein, James L. Keck, Michael M. Cox, Ana M. Misic, Julie M. Eggington, Michael P. Killoran
Publikováno v:
Proceedings of the National Academy of Sciences. 101:8575-8580
Single-stranded DNA (ssDNA)-binding (SSB) proteins are uniformly required to bind and protect single-stranded intermediates in DNA metabolic pathways. All bacterial and eukaryotic SSB proteins studied to date oligomerize to assemble four copies of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8402a1e2e1eda34cc9e0a0ee154d139
https://doi.org/10.1073/pnas.0401331101
https://doi.org/10.1073/pnas.0401331101
Autor:
Michael P. Killoran, James L. Keck
Publikováno v:
The Journal of biological chemistry. 281(18)
RecQ helicases are key genome maintenance enzymes that function in DNA replication, recombination, and repair. In contrast to nearly every other identified RecQ family member, the RecQ helicase from the radioresistant bacterium Deinococcus radioduran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::316c8a586dfe72fe8dab240bc36052d6
https://pubmed.ncbi.nlm.nih.gov/16531400
https://pubmed.ncbi.nlm.nih.gov/16531400
Autor:
Michael P. Killoran, Sergiy Levin, Michelle E. Boursier, Kristopher Zimmerman, Robin Hurst, Mary P. Hall, Thomas Machleidt, Thomas A. Kirkland, Rachel Friedman Ohana
Publikováno v:
Molecules, Vol 26, Iss 10, p 2857 (2021)
Gaining insight into the pharmacology of ligand engagement with G-protein coupled receptors (GPCRs) under biologically relevant conditions is vital to both drug discovery and basic research. NanoLuc-based bioluminescence resonance energy transfer (Na
Externí odkaz:
https://doaj.org/article/6603ab2a2c3e4fc183fbdeba047372cc