Zobrazeno 1 - 10
of 102
pro vyhledávání: '"Michael P Kavanaugh"'
Autor:
Alan C Foster, Jill Farnsworth, Genevieve E Lind, Yong-Xin Li, Jia-Ying Yang, Van Dang, Mahmud Penjwini, Veena Viswanath, Ursula Staubli, Michael P Kavanaugh
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156551 (2016)
N-methyl-D-aspartate (NMDA) receptors play critical roles in synaptic transmission and plasticity. Activation of NMDA receptors by synaptically released L-glutamate also requires occupancy of co-agonist binding sites in the tetrameric receptor by eit
Externí odkaz:
https://doaj.org/article/0fc9a259394b49028075712dc587e026
Autor:
Jonathan C Andrews, María Paz Fernández, Qin Yu, Greg P Leary, Adelaine K W Leung, Michael P Kavanaugh, Edward A Kravitz, Sarah J Certel
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004356 (2014)
Chemosensory pheromonal information regulates aggression and reproduction in many species, but how pheromonal signals are transduced to reliably produce behavior is not well understood. Here we demonstrate that the pheromonal signals detected by Gr32
Externí odkaz:
https://doaj.org/article/a6d08576ca664424903aecb89f3c29ea
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70947 (2013)
Mammals express seven transporters from the SLC1 (solute carrier 1) gene family, including five acidic amino acid transporters (EAAT1-5) and two neutral amino acid transporters (ASCT1-2). In contrast, insects of the order Diptera possess only two SLC
Externí odkaz:
https://doaj.org/article/62ee6b89ce4744a2b49183e2db58dbac
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23765 (2011)
In this study we characterized the pharmacological selectivity and physiological actions of a new arylaspartate glutamate transporter blocker, L-threo-ß-benzylaspartate (L-TBA). At concentrations up to 100 µM, L-TBA did not act as an AMPA receptor
Externí odkaz:
https://doaj.org/article/fdb5476d66c947d987469a7c2b888b5b
Autor:
Brent R. Lyda, Gregory P. Leary, Jill Farnsworth, Benjamin Seaver, Derek Silvius, Michael P. Kavanaugh, C. Sean Esslinger, Nicholas R. Natale
Publikováno v:
Molecules, Vol 29, Iss 10, p 2330 (2024)
As a conformationally restricted amino acid, hydroxy-l-proline is a versatile scaffold for the synthesis of diverse multi-functionalized pyrrolidines for probing the ligand binding sites of biological targets. With the goal to develop new inhibitors
Externí odkaz:
https://doaj.org/article/09739a5a115743fe8c51173f32001947
Autor:
Megan L. Ratz, Greg Leary, Andrea Grindeland, Derek Silvius, Joseph Guter, Michael P. Kavanaugh, Teresa M. Gunn
SLC1A4 (solute carrier family 1 member 4, also referred to as ASCT1, Alanine/Serine/Cysteine/Threonine-preferring Transporter 1) is a sodium-dependent neutral amino acid transporter. It is highly expressed in many tissues, including the brain, where
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70e14f1c4c49bde0550818580a627c16
https://doi.org/10.21203/rs.3.rs-2839029/v1
https://doi.org/10.21203/rs.3.rs-2839029/v1
Publikováno v:
Diagnostics, Vol 11, Iss 5, p 768 (2021)
Malaria rapid diagnostic tests (RDTs) have had an enormous global impact which contributed to the World Health Organization paradigm shift from empiric treatment to obtaining a parasitological diagnosis prior to treatment. Microscopy, the classic sta
Externí odkaz:
https://doaj.org/article/674c64b319194f50a9162bd0d0415229
Autor:
Colin G. Miller, Jean A. Kundert, Justin R. Prigge, Julie A. Amato, Allison E. Perez, Lucia Coppo, Gabrielle N. Rizzo, Michael P. Kavanaugh, David J. Orlicky, Colin T. Shearn, Edward E. Schmidt
Publikováno v:
Antioxidants, Vol 10, Iss 3, p 359 (2021)
Cellular oxidants are primarily managed by the thioredoxin reductase-1 (TrxR1)- and glutathione reductase (Gsr)-driven antioxidant systems. In mice having hepatocyte-specific co-disruption of TrxR1 and Gsr (TrxR1/Gsr-null livers), methionine cataboli
Externí odkaz:
https://doaj.org/article/98510a8d188d4921848458dea2409ac7
Autor:
Ottavio Arancio, Rose Pitstick, Michael P. Kavanaugh, Russell E. Nicholls, Agnieszka Staniszewski, Madhumathi Gnanaprakash, Hong Zhang
Publikováno v:
Journal of Alzheimer's Disease
Background: The serine/threonine protein phosphatase, PP2A, is thought to play a central role in the molecular pathogenesis of Alzheimer’s disease (AD), and the activity and substrate specificity of PP2A is regulated, in part, through methylation a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0540cea074ddd18bc55ffe34e016e3
http://europepmc.org/articles/PMC8203222
http://europepmc.org/articles/PMC8203222
Autor:
Brent R. Lyda, Gregory P. Leary, Jill Farnsworth, Derek Silvius, Benjamin Seaver, C. Sean Esslinger, Nicholas R. Natale, Michael P. Kavanaugh
The conformationally restricted heterocycle hydroxy-L-proline is a versatile scaffold for the synthesis of diverse multi-functionalized pyrrolidines for probing the ligand binding sites of biological targets. With the goal to develop new inhibitors o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16821e2ba966c8cf06206d75570da98d
https://doi.org/10.1101/2021.12.14.470456
https://doi.org/10.1101/2021.12.14.470456