Zobrazeno 1 - 10
of 73
pro vyhledávání: '"Michael P Jankowski"'
Autor:
Frank L Rice, George Houk, James P Wymer, Sara J C Gosline, Justin Guinney, Jianqiang Wu, Nancy Ratner, Michael P Jankowski, Salvo La Rosa, Marilyn Dockum, James R Storey, Steven L Carroll, Phillip J Albrecht, Vincent M Riccardi
Publikováno v:
PLoS ONE, Vol 14, Iss 5, p e0216527 (2019)
In addition to large plexiform neurofibromas (pNF), NF1 patients are frequently disfigured by cutaneous neurofibromas (cNF) and are often afflicted with chronic pain and itch even from seemingly normal skin areas. Both pNFs and cNF consist primarily
Externí odkaz:
https://doaj.org/article/7ed7cfa28c9741e981749ceacff2bc19
Autor:
Anthony Herbert, Michael P. Jankowski
Publikováno v:
Frontiers in Pain Research, Vol 5 (2024)
Externí odkaz:
https://doaj.org/article/7ac67364fa48426dad52c1f052ee9bb5
Autor:
Li Yang, Jesse Slone, Weiwei Zou, Luis F. Queme, Michael P. Jankowski, Fei Yin, Taosheng Huang
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 84-97 (2020)
Gene therapy now provides a novel approach for treating inherited monogenetic disorders, including nuclear gene mutations associated with mitochondrial diseases. In this study, we have utilized a mouse model carrying a p.Arg389Gln mutation of the mit
Externí odkaz:
https://doaj.org/article/adb2d3fe4f7e4ca3af12550b52302d01
Autor:
Zachary K. Ford, Adam J. Dourson, Xiaohua Liu, Peilin Lu, Kathryn J. Green, Renita C. Hudgins, Michael P. Jankowski
Publikováno v:
IBRO Reports, Vol 6, Iss , Pp 111-121 (2019)
Injury during early postnatal life causes acute alterations in afferent function and DRG gene expression, which in addition to producing short-term sensitivity has the potential to influence nociceptive responses in adulthood. We recently discovered
Externí odkaz:
https://doaj.org/article/fbe918ec375840c99ee260460f6bf6bb
Autor:
Robert A. Coover, Tabitha E. Healy, Li Guo, Katherine E. Chaney, Robert F. Hennigan, Craig S. Thomson, Lindsey E. Aschbacher-Smith, Michael P. Jankowski, Nancy Ratner
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-15 (2018)
Abstract Normal Schwann cells (SCs) are quiescent in adult nerves, when ATP is released from the nerve in an activity dependent manner. We find that suppressing nerve activity in adult nerves causes SC to enter the cell cycle. In vitro, ATP activates
Externí odkaz:
https://doaj.org/article/1bfa1d5d9ede4c02abd2406952f3a5c2
Publikováno v:
Biology of Sex Differences, Vol 9, Iss 1, Pp 1-14 (2018)
Abstract Background Chronic pain conditions are more prevalent in women, but most preclinical studies into mechanisms of pain generation are performed using male animals. Furthermore, whereas group III and IV nociceptive muscle afferents provoke cent
Externí odkaz:
https://doaj.org/article/5bf43de643864e809f8313a90e0d4ed6
Autor:
Namrata G.R. Raut, Laura A. Maile, Leila M. Oswalt, Irati Mitxelena, Aaditya Adlakha, Kourtney L. Sprague, Ashley R. Rupert, Lane Bokros, Megan C. Hofmann, Jennifer Patritti-Cram, Tilat A. Rizvi, Luis F. Queme, Kwangmin Choi, Nancy Ratner, Michael P. Jankowski
SummaryPain of unknown etiology is frequent in individuals with the tumor predisposition syndrome Neurofibromatosis 1 (NF1), even when tumors are absent. Schwann cells (SC) were recently shown to play roles in nociceptive processing, and we find that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbff1a05aa1b73e322bcc5e956bd6d99
https://doi.org/10.1101/2023.03.18.533004
https://doi.org/10.1101/2023.03.18.533004
Publikováno v:
PM&R. 14:1490-1496
Hyaluronan (HA) is a glycosaminoglycan that consists of single-chain polymers of disaccharide units of glucuronic acid and N-acetylglucosamine. It is a chief constituent of the extracellular matrix. About 27% of the total HA in the body is expressed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6767b0085bf07515309bda2f51771be
https://doi.org/10.1002/pmrj.12771
https://doi.org/10.1002/pmrj.12771
Autor:
Adam J. Dourson, Adewale O. Fadaka, Anna M. Warshak, Aditi Paranjpe, Benjamin Weinhaus, Luis F. Queme, Megan C. Hofmann, Heather M. Evans, Omer A. Donmez, Carmy Forney, Matthew T. Weirauch, Leah C. Kottyan, Daniel Lucas, George S. Deepe, Michael P. Jankowski
Publikováno v:
bioRxiv
The developing peripheral nervous and immune systems are functionally distinct from adults. These systems are vulnerable to effects of early life injury which can influence outcomes related to nociception following subsequent injury later in life (i.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79a7fbc1c42467b36a36b62498dcd6c8
https://doi.org/10.1101/2023.02.13.528015
https://doi.org/10.1101/2023.02.13.528015
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 11 (2017)
Musculoskeletal pain due to ischemia is present in a variety of clinical conditions including peripheral vascular disease (PVD), sickle cell disease (SCD), complex regional pain syndrome (CRPS), and even fibromyalgia (FM). The clinical features assoc
Externí odkaz:
https://doaj.org/article/619ff6d9ed4b49d3b6024bc0c5f3641f