Zobrazeno 1 - 10
of 114
pro vyhledávání: '"Michael P Brenner"'
Publikováno v:
New Journal of Physics, Vol 25, Iss 10, p 103029 (2023)
The transfer of kinetic energy from large to small scales is a hallmark of turbulent flows. Yet, a precise mechanistic description of this transfer, which is expected to occur via an energy cascade, is still missing. Several conceptually simple confi
Externí odkaz:
https://doaj.org/article/f31c68610810400d8066ad74407021b1
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 11, p e1009576 (2021)
Advances in genetic engineering technologies have allowed the construction of artificial genetic circuits, which have been used to generate spatial patterns of differential gene expression. However, the question of how cells can be programmed, and ho
Externí odkaz:
https://doaj.org/article/85a2c56e6abf4ee6bfbf13147ce55aa5
Autor:
Sarah F Poole, Jessica Gronsbell, Dale Winter, Stefanie Nickels, Roie Levy, Bin Fu, Maximilien Burq, Sohrab Saeb, Matthew D Edwards, Michael K Behr, Vignesh Kumaresan, Alexander R Macalalad, Sneh Shah, Michelle Prevost, Nigel Snoad, Michael P Brenner, Lance J Myers, Paul Varghese, Robert M Califf, Vindell Washington, Vivian S Lee, Menachem Fromer
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0254798 (2021)
As society has moved past the initial phase of the COVID-19 crisis that relied on broad-spectrum shutdowns as a stopgap method, industries and institutions have faced the daunting question of how to return to a stabilized state of activities and more
Externí odkaz:
https://doaj.org/article/819af61d30ee4049861b098253ef316a
Autor:
Garrett Dunlap, Aaron Wagner, Nida Meednu, Ruoqiao Wang, Fan Zhang, Jabea Cyril Ekabe, Anna Helena Jonsson, Kevin Wei, Saori Sakaue, Aparna Nathan, Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network, Vivian P. Bykerk, Laura T. Donlin, Susan M. Goodman, Gary S. Firestein, David L. Boyle, V. Michael Holers, Larry W. Moreland, Darren Tabechian, Costantino Pitzalis, Andrew Filer, Soumya Raychaudhuri, Michael B. Brenner, Juilee Thakar, Andrew McDavid, Deepak A. Rao, Jennifer H. Anolik
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Rheumatoid arthritis (RA) is an autoimmune disease involving antigen-specific T and B cells. Here, we perform single-cell RNA and repertoire sequencing on paired synovial tissue and blood samples from 12 seropositive RA patients. We identify
Externí odkaz:
https://doaj.org/article/b76b85a9921847d4919133eeb47ed023
Autor:
Arianna Di Stadio, Massimo Ralli, Pietro De Luca, Jake Sossamon, Teresa C. Frohman, Marta Altieri, Ignazio La Mantia, Salvatore Ferlito, Elliot M. Frohman, Michael J. Brenner
Publikováno v:
Frontiers in Neurology, Vol 15 (2024)
BackgroundFacial synkinesis (FS) is a distressing sequela of facial palsy (FP) characterized by involuntary, simultaneous movements of facial muscles occurring during voluntary facial expressions. Treatment of synkinesis is challenging, and preventiv
Externí odkaz:
https://doaj.org/article/c6920ae421d54453bd6aa4d0fa5f017c
Autor:
Elaine Angelino, Michael P Brenner
Publikováno v:
PLoS Computational Biology, Vol 3, Iss 9, Pp 1751-1760 (2007)
We study how functional constraints bound and shape evolution through an analysis of mammalian voltage-gated sodium channels. The primary function of sodium channels is to allow the propagation of action potentials. Since Hodgkin and Huxley, mathemat
Externí odkaz:
https://doaj.org/article/113440e6d35f45d8966fbdaf050f0b43
Autor:
Kathryn Weinand, Saori Sakaue, Aparna Nathan, Anna Helena Jonsson, Fan Zhang, Gerald F. M. Watts, Majd Al Suqri, Zhu Zhu, Accelerating Medicines Partnership Program: Rheumatoid Arthritis and Systemic Lupus Erythematosus (AMP RA/SLE) Network, Deepak A. Rao, Jennifer H. Anolik, Michael B. Brenner, Laura T. Donlin, Kevin Wei, Soumya Raychaudhuri
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-25 (2024)
Abstract Synovial tissue inflammation is a hallmark of rheumatoid arthritis (RA). Recent work has identified prominent pathogenic cell states in inflamed RA synovial tissue, such as T peripheral helper cells; however, the epigenetic regulation of the
Externí odkaz:
https://doaj.org/article/6fa32e092ab54daeaadb71dbcca5722d
Autor:
Niall M Mangan, Michael P Brenner
Publikováno v:
eLife, Vol 4 (2015)
Externí odkaz:
https://doaj.org/article/f0701193d4524d1ab7dbc3d4b60317d2
Autor:
Xuri Yan, John Marini, Robert Mulligan, Abby Deleault, Upma Sharma, Michael P Brenner, Gregory C Rutledge, Toby Freyman, Quynh P Pham
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125407 (2015)
In this work, we report on the development of slit-surface electrospinning--a process that co-localizes two solutions along a slit surface to spontaneously emit multiple core-sheath cone-jets at rates of up to 1 L/h. To the best of our knowledge, thi
Externí odkaz:
https://doaj.org/article/6edb4e313fd643998023407dad01780f
Autor:
Niall M Mangan, Michael P Brenner
Publikováno v:
eLife, Vol 3 (2014)
Cyanobacteria are photosynthetic bacteria with a unique CO2 concentrating mechanism (CCM), enhancing carbon fixation. Understanding the CCM requires a systems level perspective of how molecular components work together to enhance CO2 fixation. We pre
Externí odkaz:
https://doaj.org/article/baa99150ec3c4704b6ad905d895c4edc