Zobrazeno 1 - 10
of 191
pro vyhledávání: '"Michael P, Pollastri"'
Autor:
Amrita Sharma, Carlos E. Sanz-Rodriguez, Michael P. Pollastri, Andrei Purmal, Kojo Mensa-Wilmot
Publikováno v:
Frontiers in Drug Discovery, Vol 4 (2024)
The criteria for the progression of hits in the discovery of leads for human African trypanosomiasis (HAT), a neglected disease caused by the microbial eukaryote Trypanosoma brucei, are not standardized. Hits are advanced upon meeting thresholds for
Externí odkaz:
https://doaj.org/article/65e49f0f758847c6b3614b0c90b244f6
Autor:
Lori Ferrins, Melissa J. Buskes, Madison M. Kapteyn, Hannah N. Engels, Suzanne E. Enos, Chenyang Lu, Dana M. Klug, Baljinder Singh, Antonio Quotadamo, Kelly Bachovchin, Westley F. Tear, Andrew E. Spaulding, Katherine C. Forbes, Seema Bag, Mitch Rivers, Catherine LeBlanc, Erin Burchfield, Jeremy R. Armand, Rosario Diaz-Gonzalez, Gloria Ceballos-Perez, Raquel García-Hernández, Guiomar Pérez-Moreno, Cristina Bosch-Navarrete, Claudia Gómez-Liñán, Luis Miguel Ruiz-Pérez, Francisco Gamarro, Dolores González-Pacanowska, Miguel Navarro, Kojo Mensa-Wilmot, Michael P. Pollastri, Dennis E. Kyle, Christopher A. Rice
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/0f2b847142f74e518b6ce0db61ac7a90
Autor:
Lori Ferrins, Melissa J. Buskes, Madison M. Kapteyn, Hannah N. Engels, Suzanne E. Enos, Chenyang Lu, Dana M. Klug, Baljinder Singh, Antonio Quotadamo, Kelly Bachovchin, Westley F. Tear, Andrew E. Spaulding, Katherine C. Forbes, Seema Bag, Mitch Rivers, Catherine LeBlanc, Erin Burchfield, Jeremy R. Armand, Rosario Diaz-Gonzalez, Gloria Ceballos-Perez, Raquel García-Hernández, Guiomar Pérez-Moreno, Cristina Bosch-Navarrete, Claudia Gómez-Liñán, Luis Miguel Ruiz-Pérez, Francisco Gamarro, Dolores González-Pacanowska, Miguel Navarro, Kojo Mensa-Wilmot, Michael P. Pollastri, Dennis E. Kyle, Christopher A. Rice
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Acanthamoeba species, Naegleria fowleri, and Balamuthia mandrillaris are opportunistic pathogens that cause a range of brain, skin, eye, and disseminated diseases in humans and animals. These pathogenic free-living amoebae (pFLA) are commonly misdiag
Externí odkaz:
https://doaj.org/article/d32dd50bf4c74ebf995a90e8b2cf426f
Autor:
Baljinder Singh, Amrita Sharma, Naresh Gunaganti, Mitch Rivers, Pradip K. Gadekar, Brady Greene, Michael Chichioco, Carlos E. Sanz-Rodriguez, Courtney Fu, Catherine LeBlanc, Erin Burchfield, Nyle Sharif, Benjamin Hoffman, Gaurav Kumar, Andrei Purmal, Kojo Mensa-Wilmot, Michael P. Pollastri
Publikováno v:
Journal of Medicinal Chemistry. 66:1972-1989
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ac939a7ecc5659e3a6ab308ed6f629b5
https://doi.org/10.1021/acs.jmedchem.2c01767
https://doi.org/10.1021/acs.jmedchem.2c01767
Autor:
Dana M Klug, Rosario Diaz-Gonzalez, Guiomar Pérez-Moreno, Gloria Ceballos-Pérez, Raquel García-Hernández, Veronica Gomez-Pérez, Luis Miguel Ruiz-Pérez, Domingo I Rojas-Barros, Francisco Gamarro, Dolores González-Pacanowska, María S Martínez-Martínez, Pilar Manzano, Lori Ferrins, Conor R Caffrey, Miguel Navarro, Michael P Pollastri
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 2, p e0007129 (2019)
New treatments are needed for neglected tropical diseases (NTDs) such as Human African trypanosomiasis (HAT), Chagas disease, and schistosomiasis. Through a whole organism high-throughput screening campaign, we previously identified 797 human kinase
Externí odkaz:
https://doaj.org/article/8cc5ddaa83b043e2aaad8dbc1ec31ea7
Autor:
Jing Chai, Christopher C. Arico-Muendel, Yun Ding, Michael P. Pollastri, Sarah Scott, Mark A. Mantell, Gang Yao
Publikováno v:
Bioconjugate Chemistry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::01894bd9cebe01e4506e451d4c7c775b
https://doi.org/10.1021/acs.bioconjchem.3c00159
https://doi.org/10.1021/acs.bioconjchem.3c00159
Autor:
Lori Ferrins, Amrita Sharma, Sarah M Thomas, Naimee Mehta, Jessey Erath, Scott Tanghe, Susan E Leed, Ana Rodriguez, Kojo Mensa-Wilmot, Richard J Sciotti, Kirsten Gillingwater, Michael P Pollastri
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 11, p e0006834 (2018)
We recently reported the medicinal chemistry re-optimization of a series of compounds derived from the human tyrosine kinase inhibitor, lapatinib, for activity against Plasmodium falciparum. From this same library of compounds, we now report potent c
Externí odkaz:
https://doaj.org/article/7cdba245bb1545f0a3fa0706ebb2f1b2
Autor:
Sabrina Absalon, Karin Blomqvist, Rachel M. Rudlaff, Travis J. DeLano, Michael P. Pollastri, Jeffrey D. Dvorin
Publikováno v:
mBio, Vol 9, Iss 1 (2018)
ABSTRACT The human malaria parasite Plasmodium falciparum requires efficient egress out of an infected red blood cell for pathogenesis. This egress event is highly coordinated and is mediated by several signaling proteins, including the plant-like P.
Externí odkaz:
https://doaj.org/article/9ff6ac7be22a4dbebd4235997aee08ce
Publikováno v:
Bioconjugate Chemistry. 32:1973-1978
Enzymatic catalysis is a highly attractive approach to the DNA encoded library technology (DEL) that has not been widely explored. In this paper, we report an l-threonine aldolase (l-TA)-catalyzed on-DNA aldol reaction to form β-hydroxy-α-amino aci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a164b66f0206eafaa1e8f5a681876f5
https://doi.org/10.1021/acs.bioconjchem.1c00363
https://doi.org/10.1021/acs.bioconjchem.1c00363
Autor:
Stefan Kunz, Vreni Balmer, Geert Jan Sterk, Michael P Pollastri, Rob Leurs, Norbert Müller, Andrew Hemphill, Cornelia Spycher
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 9, p e0005891 (2017)
Giardiasis is an intestinal infection correlated with poverty and poor drinking water quality, and treatment options are limited. According to the Center for Disease Control and Prevention, Giardia infections afflict nearly 33% of people in developin
Externí odkaz:
https://doaj.org/article/580d824ade96445cb76c84ca416c0ed3