Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Michael P, Poirier"'
Autor:
Ariel Robbins, Hazen Hildebolt, Michael Neuhoff, Peter Beshay, Jessica O. Winter, Carlos E. Castro, Ralf Bundschuh, Michael G. Poirier
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Biomolecular systems are dependent on a complex interplay of forces. Modern force spectroscopy techniques provide means of interrogating these forces, but they are not optimized for studies in constrained environments as they require attachm
Externí odkaz:
https://doaj.org/article/9d8b1719f3fd49ac8789b779e7d5820d
Autor:
Dustin C. Becht, Akinori Kanai, Soumi Biswas, Mohamed Halawa, Lei Zeng, Khan L. Cox, Michael G. Poirier, Ming-Ming Zhou, Xiaobing Shi, Akihiko Yokoyama, Tatiana G. Kutateladze
Publikováno v:
iScience, Vol 27, Iss 4, Pp 109367- (2024)
Summary: Acetylation of histones by lysine acetyltransferases (KATs) provides a fundamental mechanism by which chromatin structure and transcriptional programs are regulated. Here, we describe a dual binding activity of the first winged helix domain
Externí odkaz:
https://doaj.org/article/d253eb29fab6433ca64c40b9bbb935fc
Autor:
Dustin C. Becht, Brianna J. Klein, Akinori Kanai, Suk Min Jang, Khan L. Cox, Bing-Rui Zhou, Sabrina K. Phanor, Yi Zhang, Ruo-Wen Chen, Christopher C. Ebmeier, Catherine Lachance, Maxime Galloy, Amelie Fradet-Turcotte, Martha L. Bulyk, Yawen Bai, Michael G. Poirier, Jacques Côté, Akihiko Yokoyama, Tatiana G. Kutateladze
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Human acetyltransferases MOZ and MORF mediate development programs and are dysregulated in diseases. Here the authors identified two winged helix (WH) domains in MORF/MOZ and characterized their DNA binding functions, including targeting of CpG by WH
Externí odkaz:
https://doaj.org/article/a2ad2ef5ddc546e58f71dca700b8f668
Autor:
Ehsan Akbari, Melika Shahhosseini, Ariel Robbins, Michael G. Poirier, Jonathan W. Song, Carlos E. Castro
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Single molecule force spectroscopy methods are often low throughput and have high instrument cost. Here the authors report FLO-Chip, a low-cost, high throughput technique using microfluidics for multiplexed mechanical manipulation of many individual
Externí odkaz:
https://doaj.org/article/88018e100aa44999993ef068c1501908
Autor:
Sean T. Smrt, Nicole Gonzalez Salguero, Justin K. Thomas, Mohamad Zandian, Michael G. Poirier, Christopher P. Jaroniec
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2023)
Chromatin, a dynamic protein-DNA complex that regulates eukaryotic genome accessibility and essential functions, is composed of nucleosomes connected by linker DNA with each nucleosome consisting of DNA wrapped around an octamer of histones H2A, H2B,
Externí odkaz:
https://doaj.org/article/08f18d8e43fb41109a73bc8c612446c8
Autor:
Brianna J. Klein, Anagha Deshpande, Khan L. Cox, Fan Xuan, Mohamad Zandian, Karina Barbosa, Sujita Khanal, Qiong Tong, Yi Zhang, Pan Zhang, Amit Sinha, Stefan K. Bohlander, Xiaobing Shi, Hong Wen, Michael G. Poirier, Aniruddha J. Deshpande, Tatiana G. Kutateladze
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Chromosomal translocations involving the AF10 gene, especially with CALM, are associated with aggressive leukemias. Here the authors show that the PZP domain of AF10, a histone reader, is always excluded/impaired in AF10 fusions, whereas incorporatio
Externí odkaz:
https://doaj.org/article/bc1ee92ef2674d4cb5c121a8d5e098c2
Autor:
Adam H. Tencer, Khan L. Cox, Gregory M. Wright, Yi Zhang, Christopher J. Petell, Brianna J. Klein, Brian D. Strahl, Joshua C. Black, Michael G. Poirier, Tatiana G. Kutateladze
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Human Microrchidia 4 (MORC4) ATPase has been implicated in acute and chronic pancreatitis, inflammatory disorders and cancer. Here the authors describe the structure–function relationship of MORC4 and define the molecular mechanism for MORC4 activa
Externí odkaz:
https://doaj.org/article/bae9c480125f473e8a017411be513b35
Autor:
Brianna J. Klein, Khan L. Cox, Suk Min Jang, Rohit K. Singh, Jacques Côté, Michael G. Poirier, Tatiana G. Kutateladze
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100479- (2021)
Summary: The core subunit of the MORF acetyltransferase complex BRPF1 contains a unique combination of zinc fingers, including a plant homeodomain (PHD) finger followed by a zinc knuckle and another PHD finger, which together form a PZP domain (BRPF1
Externí odkaz:
https://doaj.org/article/a0fd143f19b94e7ea9ae4c1f09faf24e
Autor:
Jovylyn Gatchalian, Xiaodong Wang, Jinzen Ikebe, Khan L. Cox, Adam H. Tencer, Yi Zhang, Nathaniel L. Burge, Luo Di, Matthew D. Gibson, Catherine A. Musselman, Michael G. Poirier, Hidetoshi Kono, Jeffrey J. Hayes, Tatiana G. Kutateladze
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
The chromatin remodeller CHD4 contains two PHD finger reader domains that have been shown to bivalently recognize H3 histone tails. Here, the authors describe a mechanism by which the PHD fingers bind to the intact nucleosome core particle, revealing
Externí odkaz:
https://doaj.org/article/80503b36d74a4bc3b72aa20bc28f7b84
Autor:
Adam H. Tencer, Khan L. Cox, Luo Di, Joseph B. Bridgers, Jie Lyu, Xiaodong Wang, Jennifer K. Sims, Tyler M. Weaver, Hillary F. Allen, Yi Zhang, Jovylyn Gatchalian, Michael A. Darcy, Matthew D. Gibson, Jinzen Ikebe, Wei Li, Paul A. Wade, Jeffrey J. Hayes, Brian D. Strahl, Hidetoshi Kono, Michael G. Poirier, Catherine A. Musselman, Tatiana G. Kutateladze
Publikováno v:
Cell Reports, Vol 21, Iss 2, Pp 455-466 (2017)
Summary: Chromatin remodeling is required for genome function and is facilitated by ATP-dependent complexes, such as nucleosome remodeling and deacetylase (NuRD). Among its core components is the chromodomain helicase DNA binding protein 3 (CHD3) who
Externí odkaz:
https://doaj.org/article/7ca566c3011e443687e83fac93b1d9f8