Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Michael P, Mannino"'
Autor:
Jie L. Tian, Chia-Wei Huang, Farzad Eslami, Michael Philip Mannino, Rebecca Lee Mai, Gerald W. Hart
Publikováno v:
Cells, Vol 12, Iss 11, p 1520 (2023)
The primary cilium plays critical roles in the homeostasis and development of neurons. Recent studies demonstrate that cilium length is regulated by the metabolic state of cells, as dictated by processes such as glucose flux and O-GlcNAcylation (OGN)
Externí odkaz:
https://doaj.org/article/a8efe644c06e4b95aa0425c17d17da86
Autor:
Michael P. Mannino, Gerald W. Hart
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The addition of N-acetyl glucosamine (GlcNAc) on the hydroxy group of serine/threonine residues is known as O-GlcNAcylation (OGN). The dynamic cycling of this monosaccharide on and off substrates occurs via O-linked β-N-acetylglucosamine transferase
Externí odkaz:
https://doaj.org/article/10668495af1f4e4883fa118d16d0f4de
Publikováno v:
Chemistry – A European Journal. 26:2938-2946
Excellent β-stereoselectivity for the glycosylation with glucosyl donors equipped with the 3-O-picoloyl (Pico) group, without the use of participating group, was achieved in the presence of NIS/excess TfOH promoter system. A complete investigation o
Publikováno v:
Org Biomol Chem
The picoloyl ester (Pico) has proven to be a versatile protecting group in carbohydrate chemistry. It can be used for the purpose of stereocontrolling glycosylations via an H-bond-mediated Aglycone Delivery (HAD) method. It can also be used as a temp
Publikováno v:
Journal of Chemical Education. 96:2322-2325
A robust laboratory protocol for the three-step synthesis of p-tolyl 2,3,4,6-tetra-O-benzoyl-1-thio-β-d-glucopyranoside from commercial glucose pentaacetate is reported. The previously reported procedures have been modified to accommodate laboratori
Publikováno v:
Encyclopedia of Biological Chemistry III ISBN: 9780128220405
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::89acf71ac60df60ae2acf0c9ac17ee97
https://doi.org/10.1016/b978-0-12-809633-8.21364-2
https://doi.org/10.1016/b978-0-12-809633-8.21364-2
The stereocontrol of glycosylation reactions is a constant struggle in the field of synthetic carbohydrate chemistry. The application of the picoloyl (Pico) substituent can offer numerous stereocontrolling avenues. The most popular application is the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::08be9a8cf0e03b461ff83436cebbb7da
https://doi.org/10.1039/9781788013864-00093
https://doi.org/10.1039/9781788013864-00093
Publikováno v:
Chemistry (Weinheim an der Bergstrasse, Germany). 26(13)
Our previous study showed that picoloylated donors are capable of providing excellent facial stereoselectivity through the H-bond-mediated aglycone delivery (HAD) pathway. Presented herein is a detailed mechanistic study of stereoselective glycosylat
Autor:
Michael P. Mannino, Bruce C. Hamper, Christopher D. Spilling, Liam T. Harrison, Melissa E. Mueller
Publikováno v:
Chirality. 28:656-662
Chromatographic separation of the enantiomers of parent compounds dimethyl α-hydroxyallyl phosphonate and 1-(dimethoxyphosphoryl) allyl methyl carbonate was demonstrated by high-performance liquid chromatography (HPLC) using Chiralpak AS-H and ad-H
Publikováno v:
Carbohydrate research. 470
In an attempt to refine the H-bond-mediated Aglycone Delivery (HAD) glycosylation reaction reported herein is the synthesis of β-glucosides using an ethylthio glucoside donor equipped with the remote 6-O-picoloyl substituent. Upon examining various