T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis

Autor: Ruth J. Napier, Ellen J. Lee, Michael P. Davey, Emily E. Vance, João M. Furtado, Paige E. Snow, Kimberly A. Samson, Sydney J. Lashley, Brieanna R. Brown, Reiko Horai, Mary J. Mattapallil, Biying Xu, Michelle C. Callegan, Luke S. Uebelhoer, Christina L. Lancioni, Richard K. Vehe, Bryce A. Binstadt, Justine R. Smith, Rachel R. Caspi, Holly L. Rosenzweig

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)

How mutations in the microbial receptor NOD2 induce Blau syndrome in humans and related uveitis is unclear. Here the authors show, using Nod2-deficient mice and experimental uveitis, that Nod2 negatively regulates T cell activation and transcription

Externí odkaz: https://doaj.org/article/5c09fe5a329b4c398f56c7642549fe79

T cell-intrinsic role for Nod2 in protection against Th17-mediated uveitis

Autor: Bryce A. Binstadt, João M. Furtado, Michael P. Davey, Paige E. Snow, Biying Xu, Ruth J. Napier, Christina Lancioni, Kimberly A. Samson, Michelle C. Callegan, E. J. Lee, Mary J. Mattapallil, Holly L. Rosenzweig, Emily E. Vance, Sydney Lashley, Reiko Horai, Luke S. Uebelhoer, Brieanna Brown, Rachel R. Caspi, Richard K. Vehe, Justine R. Smith

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual)
Universidade de São Paulo (USP)
instacron:USP
Nature Communications

Mutations in nucleotide-binding oligomerization domain-containing protein 2 (NOD2) cause Blau syndrome, an inflammatory disorder characterized by uveitis. The antimicrobial functions of Nod2 are well-established, yet the cellular mechanisms by which

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b42c7e920b9a31c5f909265b99df89d
https://doaj.org/article/5c09fe5a329b4c398f56c7642549fe79

In vitro germination of Podophyllum hexandrum seeds.

Autor: Cláudia Gontijo Silva, Michael Raymond Davey, John Brian Power, Julian Mark Hugh Shaw

Publikováno v: Ornamental Horticulture, Vol 13 (2007)

Considerable interest has centred on the Podophyllum-based lignans as lead compounds for the development of new drugs. The successful introduction of the anticancer drugs etoposide® and teniposide® and the development of new derivatives such as eto

Externí odkaz: https://doaj.org/article/ab0d6ce5b6e24dd18a20eb8a06fbd3ab

Nod2-deficiency augments Th17-responses and exacerbates autoimmune arthritis

Autor: Emily E. Vance, Shimon Sakaguchi, Peter Stenzel, Kimberly A. Samson, Paige E. Snow, Michael P. Davey, Clare E. Dawson, Amy E. Moran, Ruth J. Napier, Holly L. Rosenzweig, E. J. Lee

Arthritis in a genetically susceptible SKG strain of mice models a theoretical paradigm wherein autoimmune arthritis arises because of interplay between preexisting autoreactive T cells and environmental stimuli. SKG mice have a point mutation in ZAP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6d8462aec01bd954188e04fdc016752
https://europepmc.org/articles/PMC6143404/

Interferon-γ regulates discordant mechanisms of uveitis versus joint and axial disease in a murine model resembling spondylarthritis

Autor: Tibor T. Glant, Michael P. Davey, Holly L. Rosenzweig, James T. Rosenbaum, Jelena Kezic

Publikováno v: Arthritis & Rheumatism. 64:762-771

OBJECTIVE—The spondyloarthropathies (such as ankylosing spondylitis) are multi-system inflammatory diseases that frequently result in uveitis, or intra-ocular eye inflammation. Despite the common co-occurrence of uveitis with arthritis, there has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::915bbfc3c7dec9a2a223f84037eed6ca
https://doi.org/10.1002/art.33404