Zobrazeno 1 - 10
of 201
pro vyhledávání: '"Michael P, Coleman"'
Autor:
Jong Hoon Lee, Consolato Sergi, Richard E. Kast, Badar A. Kanwar, Jean Bourbeau, Sangsuk Oh, Mun-Gi Sohn, Chul Joong Lee, Michael D. Coleman
Publikováno v:
Virology Journal, Vol 21, Iss 1, Pp 1-15 (2024)
Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces immune-mediated diseases. The pathophysiology of COVID-19 uses the following three mechanisms: (1) inflammasome activation mechanism; (2) cGAS–STING signaling mechanism;
Externí odkaz:
https://doaj.org/article/499a6cd62daa4ec48434023b2df37b92
Autor:
James R. Tribble, Melissa Jöe, Carmine Varricchio, Amin Otmani, Alessio Canovai, Baninia Habchi, Evangelia Daskalakis, Romanas Chaleckis, Andrea Loreto, Jonathan Gilley, Craig E. Wheelock, Gauti Jóhannesson, Raymond C. B. Wong, Michael P. Coleman, Andrea Brancale, Pete A. Williams
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Maintenance of NAD pools is critical for neuronal survival. The capacity to maintain NAD pools declines in neurodegenerative disease. We identify that low NMNAT2, the critical neuronal NAD producing enzyme, drives retinal susceptibility to n
Externí odkaz:
https://doaj.org/article/752e0ceae3fe4a6387d7e708ced0fe15
Autor:
Michael F. Coleman, Eylem Kulkoyluoglu Cotul, Alexander J. Pfeil, Emily N. Devericks, Muhammad H. Safdar, Marvis Monteiro, Hao Chen, Alyssa N. Ho, Numair Attaar, Hannah M. Malian, Violet A. Kiesel, Alexis Ramos, Matthew Smith, Heena Panchal, Adam Mailloux, Dorothy Teegarden, Stephen D. Hursting, Michael K. Wendt
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-20 (2024)
Abstract Background Metabolic plasticity mediates breast cancer survival, growth, and immune evasion during metastasis. However, how tumor cell metabolism is influenced by and feeds back to regulate breast cancer progression are not fully understood.
Externí odkaz:
https://doaj.org/article/4bc52c528bb64c7f812b584380877b6e
Autor:
James R. Tribble, Melissa Jöe, Carmine Varricchio, Amin Otmani, Alessio Canovai, Baninia Habchi, Evangelia Daskalakis, Romanas Chaleckis, Andrea Loreto, Jonathan Gilley, Craig E. Wheelock, Gauti Jóhannesson, Raymond C. B. Wong, Michael P. Coleman, Andrea Brancale, Pete A. Williams
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/26dff57e67d64561bc637003537e66aa
Autor:
Sen Yang, Zhen-Xian Niou, Andrea Enriquez, Jacob LaMar, Jui-Yen Huang, Karen Ling, Paymaan Jafar-Nejad, Jonathan Gilley, Michael P. Coleman, Jason M. Tennessen, Vidhya Rangaraju, Hui-Chen Lu
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-31 (2024)
Abstract Background Bioenergetic maladaptations and axonopathy are often found in the early stages of neurodegeneration. Nicotinamide adenine dinucleotide (NAD), an essential cofactor for energy metabolism, is mainly synthesized by Nicotinamide monon
Externí odkaz:
https://doaj.org/article/b4cc4bd0d6814ca5997b7215a718255b
Autor:
G. Rutger Persson, Cecilia Widén, Björn Wohlfart, Klas Sjöberg, Stig Steen, Michael D. Coleman, Helene Holmer
Publikováno v:
BMC Oral Health, Vol 23, Iss 1, Pp 1-11 (2023)
Abstract Objectives To assess if the results following intake of a diet using an Okinawan-based Nordic diet (OBND) over one month differs in endocrinological, periodontal clinical outcome, and serum cytokine levels compared to a standard hospital car
Externí odkaz:
https://doaj.org/article/82a321323eae488a90db9d1913469278
Autor:
Alyssa N. Ho, Violet A. Kiesel, Claire E. Gates, Bennett H. Brosnan, Scott P. Connelly, Elaine M. Glenny, Alyssa J. Cozzo, Stephen D. Hursting, Michael Francis Coleman
Publikováno v:
Cells, Vol 13, Iss 10, p 806 (2024)
Triple-negative breast cancer (TNBC) lacks targeted therapies, leaving cytotoxic chemotherapy as the current standard treatment. However, chemotherapy resistance remains a major clinical challenge. Increased insulin-like growth factor 1 signaling can
Externí odkaz:
https://doaj.org/article/1ec0970c8673497f8d4cd59562421e0f
Autor:
Kristina K. Camp, Michael F. Coleman, Tori L. McFarlane, Steven S. Doerstling, Subreen A. Khatib, Erika T. Rezeli, Alfor G. Lewis, Alexander J. Pfeil, Laura A. Smith, Laura W. Bowers, Farnaz Fouladi, Weida Gong, Elaine M. Glenny, Joel S. Parker, Ginger L. Milne, Ian M. Carroll, Anthony A. Fodor, Randy J. Seeley, Stephen D. Hursting
Publikováno v:
JCI Insight, Vol 8, Iss 19 (2023)
Obesity promotes triple-negative breast cancer (TNBC), and effective interventions are urgently needed to break the obesity-TNBC link. Epidemiologic studies indicate that bariatric surgery reduces TNBC risk, while evidence is limited or conflicted fo
Externí odkaz:
https://doaj.org/article/eb847aa873194d0fb917c72cb1aa7ccd
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Every cancer genome is unique, resulting in potentially near infinite cancer cell phenotypes and an inability to predict clinical outcomes in most cases. Despite this profound genomic heterogeneity, many cancer types and subtypes display a non-random
Externí odkaz:
https://doaj.org/article/4ca83b39aba34351bf682af1398ec6e7
Publikováno v:
Molecules, Vol 29, Iss 4, p 847 (2024)
Here, we report an adapted protocol using the Promega NAD/NADH-Glo™ Assay kit. The assay normally allows quantification of trace amounts of both oxidized and reduced forms of nicotinamide adenine dinucleotide (NAD) by enzymatic cycling, but we now
Externí odkaz:
https://doaj.org/article/15de90121f724784acf0e38f8755f98a