Zobrazeno 1 - 10
of 383
pro vyhledávání: '"Michael P, Barrett"'
Publikováno v:
BMC Genomics, Vol 25, Iss 1, Pp 1-11 (2024)
Abstract Background Archived samples, including frozen and formalin fixed paraffin embedded (FFPE) tissues, are a vast resource of clinically annotated materials for the application of high-definition genomics to improve patient management and provid
Externí odkaz:
https://doaj.org/article/9e9a057fd7994f9285c1bfaa2a32a317
Autor:
Yumei Zhou, Xianfeng Chen, Jun Chen, Conner D. Kendrick, Ramesh K. Ramanathan, Rondell P. Graham, Kimberlee F. Kossick, Lisa A. Boardman, Michael T. Barrett
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)
Abstract Although colorectal cancer (CRC) remains the second leading cause of cancer-related death in the United States, the overall incidence and mortality from the disease have declined in recent decades. In contrast, there has been a steady increa
Externí odkaz:
https://doaj.org/article/0df82daaf91a4241a8fa784c19da7fa4
Autor:
Etimbuk Umana, Clare Mills, Hannah Norman–Bruce, Hannah Mitchell, Lisa McFetridge, Fiona Lynn, Gareth McKeeman, Steven Foster, Michael J. Barrett, Damian Roland, Mark D. Lyttle, Chris Watson, Thomas Waterfield
Publikováno v:
EClinicalMedicine, Vol 78, Iss , Pp 102961- (2024)
Summary: Background: Between 1% and 4% of febrile infants, aged from birth to 90 days of age, presenting to hospital will be diagnosed with an invasive bacterial infection (IBI). Traditional teaching has advocated a treat all approach but more recent
Externí odkaz:
https://doaj.org/article/4fdf4061e0a646ca9847fbbabecbb71e
Autor:
Gayle S. Jameson, Peter J. Hosein, Erin Pierce, Mandana Kamgar, Michael S. Gordon, Courtney Snyder, Denise J. Roe, Betsy C. Wertheim, Marina Davey, Michael T. Barrett, Daniel D. Von Hoff, Erkut Borazanci
Publikováno v:
Cancer Medicine, Vol 13, Iss 12, Pp n/a-n/a (2024)
Abstract Background A previous phase IB/II study of nab‐paclitaxel + cisplatin + gemcitabine (NABPLAGEM) in 25 patients with previously untreated metastatic pancreatic ductal adenocarcinoma (PDAC) demonstrated favorable results. This phase II study
Externí odkaz:
https://doaj.org/article/2c0e7f0b47f441ccb1349c0b69fa9034
Autor:
Pieter C. Steketee, Edith Paxton, Michael P. Barrett, Michael C. Pearce, Timothy K. Connelley, Liam J. Morrison
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 23, Iss , Pp 71-77 (2023)
East Coast Fever (ECF) is a disease affecting cattle in sub-Saharan Africa, caused by the tick-borne Apicomplexan pathogen Theileria parva. The disease is a major problem for cattle farmers in affected regions and there are few methods of control, in
Externí odkaz:
https://doaj.org/article/770a1ac50af846c6a7967c134a72477c
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 5, p e0012091 (2024)
Externí odkaz:
https://doaj.org/article/0bd6effa1e274a8da89a162fc12684e4
Autor:
Corina E. Antal, Tae Gyu Oh, Stefan Aigner, En-Ching Luo, Brian A. Yee, Tania Campos, Hervé Tiriac, Katherine L. Rothamel, Zhang Cheng, Henry Jiao, Allen Wang, Nasun Hah, Elizabeth Lenkiewicz, Jan C. Lumibao, Morgan L. Truitt, Gabriela Estepa, Ester Banayo, Senada Bashi, Edgar Esparza, Ruben M. Munoz, Jolene K. Diedrich, Nicole M. Sodir, Jasmine R. Mueller, Cory R. Fraser, Erkut Borazanci, David Propper, Daniel D. Von Hoff, Christopher Liddle, Ruth T. Yu, Annette R. Atkins, Haiyong Han, Andrew M. Lowy, Michael T. Barrett, Dannielle D. Engle, Gerard I. Evan, Gene W. Yeo, Michael Downes, Ronald M. Evans
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy in need of new therapeutic options. Using unbiased analyses of super-enhancers (SEs) as sentinels of core genes involved in cell-specific function, here we uncover a druggable SE
Externí odkaz:
https://doaj.org/article/57cc744cc0404cd39ed1bebee4e6eee7
Autor:
Chelsae R. Watters, Oumar Barro, Natalie M. Elliott, Yumei Zhou, Musa Gabere, Elizabeth Raupach, Alexander T. Baker, Michael T. Barrett, Kenneth H. Buetow, Bertram Jacobs, Mahesh Seetharam, Mitesh J. Borad, Bolni Marius Nagalo
Publikováno v:
Molecular Therapy: Oncolytics, Vol 29, Iss , Pp 4-14 (2023)
Vesiculoviruses are attractive oncolytic virus platforms due to their rapid replication, appreciable transgene capacity, broad tropism, limited preexisting immunity, and tumor selectivity through type I interferon response defects in malignant cells.
Externí odkaz:
https://doaj.org/article/0f9b4133faac47bdbaa01ba69e5b9a37
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 18, Iss 2, p e0012007 (2024)
Trypanosoma brucei is a causative agent of the Human and Animal African Trypanosomiases. The mammalian stage parasites infect various tissues and organs including the bloodstream, central nervous system, skin, adipose tissue and lungs. They rely on A
Externí odkaz:
https://doaj.org/article/80c616d10ccd4ebb9a94e244ed85dd6a
Autor:
Nelson V. Simwela, W. Armand Guiguemde, Judith Straimer, Clement Regnault, Barbara H. Stokes, Luis E. Tavernelli, Fumiaki Yokokawa, Benjamin Taft, Thierry T. Diagana, Michael P. Barrett, Andrew P. Waters
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT Characterizing the mode of action of anti-malarial compounds that emerge from high-throughput phenotypic screens is central to understanding how parasite resistance to these drugs can emerge. Here, we have employed untargeted metabolomics to
Externí odkaz:
https://doaj.org/article/5bf7e7bb83394a2cb354699274035118