Zobrazeno 1 - 10
of 161
pro vyhledávání: '"Michael Overduin"'
Autor:
Jordan S.F. Chan, Seyed Amirhossein Tabatabaei Dakhili, Maria Areli Lorenzana-Carrillo, Keshav Gopal, Serena M. Pulente, Amanda A. Greenwell, Kunyan Yang, Christina T. Saed, Magnus J. Stenlund, Sally R. Ferrari, Indiresh A. Mangra-Bala, Tanin Shafaati, Rakesh K. Bhat, Farah Eaton, Michael Overduin, Sebastian Beck Jørgensen, Gregory R. Steinberg, Erin E. Mulvihill, Gopinath Sutendra, John R. Ussher
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114573- (2024)
Summary: Growth differentiation factor 15 (GDF15) is a peptide with utility in obesity, as it decreases appetite and promotes weight loss. Because obesity increases the risk for type 2 diabetes (T2D) and cardiovascular disease, it is imperative to un
Externí odkaz:
https://doaj.org/article/8e982b3f2425453094ab8152492fec0a
Autor:
Troy A. Kervin, Michael Overduin
Publikováno v:
BMC Biology, Vol 22, Iss 1, Pp 1-7 (2024)
Abstract Membranes are protein and lipid structures that surround cells and other biological compartments. We present a conceptual model wherein all membranes are organized into structural and functional zones. The assembly of zones such as receptor
Externí odkaz:
https://doaj.org/article/6033838431064747b72e6cabe3f015ff
Autor:
Uwa Iyamu, Daniel Ferrer Vinals, Bernard Tornyigah, Eliana Arango, Rakesh Bhat, Trixie Rae Adra, Simranjit Grewal, Kimberly Martin, Amanda Maestre, Michael Overduin, Bart Hazes, Stephanie K. Yanow
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
During Plasmodium falciparum infection in pregnancy, VAR2CSA is expressed on the surface of infected erythrocytes (IEs) and mediates their sequestration in the placenta. As a result, antibodies to VAR2CSA are largely restricted to women who were infe
Externí odkaz:
https://doaj.org/article/ac67599069024de5815cc342ef52bfe6
Publikováno v:
Current Research in Structural Biology, Vol 4, Iss , Pp 146-157 (2022)
The SARS-CoV-2 spike protein presents a surface with enormous membrane binding potential to host tissues and organelles of infected cells. Its exposed trimeric head binds not only the angiotensin-converting enzyme 2 (ACE2), but also host phospholipid
Externí odkaz:
https://doaj.org/article/20d063fa08bd4c14b76c4eb176af8b3d
Publikováno v:
iScience, Vol 25, Iss 8, Pp 104722- (2022)
Summary: Membrane recognition by viral spike proteins is critical for infection. Here we show the host cell membrane-binding surfaces of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike variants Alpha, Beta, Gamma, Delta, Epsilon, K
Externí odkaz:
https://doaj.org/article/145aab6d8a8d4d62a405b1a5bf7640f6
Publikováno v:
Viruses, Vol 15, Iss 2, p 447 (2023)
Variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are emerging rapidly and offer surfaces that are optimized for recognition of host cell membranes while also evading antibodies arising from vaccinations and previous infections
Externí odkaz:
https://doaj.org/article/36e72de46c544a369905b91741f5f943
Publikováno v:
Membranes, Vol 12, Iss 11, p 1161 (2022)
Membrane proteins are broadly classified as transmembrane (TM) or peripheral, with functions that pertain to only a single bilayer at a given time. Here, we explicate a class of proteins that contain both transmembrane and peripheral domains, which w
Externí odkaz:
https://doaj.org/article/642246d7cef3401b91a343145a6332b0
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Membrane readers take part in trafficking and signaling processes by localizing proteins to organelle surfaces and transducing molecular information. They accomplish this by engaging phosphoinositides (PIs), a class of lipid molecules which are found
Externí odkaz:
https://doaj.org/article/6fa7de8a26cd4f72bafd2d9351504b72
Autor:
Jack Alfred Bryant, Faye C Morris, Timothy J Knowles, Riyaz Maderbocus, Eva Heinz, Gabriela Boelter, Dema Alodaini, Adam Colyer, Peter J Wotherspoon, Kara A Staunton, Mark Jeeves, Douglas F Browning, Yanina R Sevastsyanovich, Timothy J Wells, Amanda E Rossiter, Vassiliy N Bavro, Pooja Sridhar, Douglas G Ward, Zhi-Soon Chong, Emily CA Goodall, Christopher Icke, Alvin CK Teo, Shu-Sin Chng, David I Roper, Trevor Lithgow, Adam F Cunningham, Manuel Banzhaf, Michael Overduin, Ian R Henderson
Publikováno v:
eLife, Vol 9 (2020)
The Gram-negative outer-membrane envelops the bacterium and functions as a permeability barrier against antibiotics, detergents, and environmental stresses. Some virulence factors serve to maintain the integrity of the outer membrane, including DolP
Externí odkaz:
https://doaj.org/article/f638738df7ef4c79a9be99c12141984c
Autor:
Marc Lenoir, Cansel Ustunel, Sandya Rajesh, Jaswant Kaur, Dimitri Moreau, Jean Gruenberg, Michael Overduin
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Sorting nexin 3 (SNX3) is a phosphatidylinositol 3-phosphate binding protein that localizes to early endosomes. Here the authors use NMR to resolve SNX3′s membrane interactions, revealing that membrane binding is regulated through phosphorylation o
Externí odkaz:
https://doaj.org/article/86b2c9b181b3493589dd4feb5d76f8d4