Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Michael Ochse"'
Autor:
Pasi Sihvonen, Leidys Murillo-Ramos, Niklas Wahlberg, Axel Hausmann, Alberto Zilli, Michael Ochse, Hermann S. Staude
Publikováno v:
PeerJ, Vol 9, p e11613 (2021)
The systematic position of a large and strikingly coloured reddish-black moth, Cartaletis dargei Herbulot, 2003 (Geometridae: Sterrhinae) from Tanzania, has remained questionable since its description. Here we present molecular and morphological evid
Externí odkaz:
https://doaj.org/article/499ead243e2e4a7c9cfdd525cc8b6dd9
Autor:
Hervé Geneste, Karla Drescher, Clarissa Jakob, Loïc Laplanche, Michael Ochse, Maricel Torrent
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:406-412
Herein we report the discovery of a novel series of phosphodiesterase 10A inhibitors. Optimization of a HTS hit (17) resulted in potent, selective, and brain penetrant 23 and 26; both exhibited much lower clearance in vivo and decreased volume of dis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6459b78672c9c57fb03104283c4f5693
https://doi.org/10.1016/j.bmcl.2018.12.029
https://doi.org/10.1016/j.bmcl.2018.12.029
Autor:
Anil Vasudevan, Ana Lucia Relo, Irini Akritopoulou-Zanze, Hongyu Zhao, Mario Mezler, Carolin Hoft, Willi Amberg, Frauke Pohlki, Ying Wang, Yi-Yin Ku, Justin D. Dietrich, Michael Ochse, Yanbin Lao, Huan-Qiu Li, Steven M. Hannick, Jason T. Brewer, Berthold Behl, Jens Sydor, Udo Lange, Wilfried Hornberger
Publikováno v:
Journal of medicinal chemistry. 61(17)
The glycine transporter 1 (GlyT1) has emerged as a key novel target for the treatment of schizophrenia. Herein, we report the synthesis and biological evaluation of aminotetralines and aminochromanes as novel classes of competitive GlyT1 inhibitors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ef701eae6cddb134d20a7a01fca9f0
https://pubmed.ncbi.nlm.nih.gov/30080045
https://pubmed.ncbi.nlm.nih.gov/30080045
Autor:
Michael Ochse, Gerald Langner
Publikováno v:
Musicae Scientiae. 10:185-208
Background in psychophysics Psychophysical experiments have shown that the human brain has a natural preference for harmonic sounds and relationships between musical tones. Even naïve listeners are able to distinguish harmonic from inharmonic musica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44a21790496c650fd43da22f6bbcd58d
https://doi.org/10.1177/102986490601000109
https://doi.org/10.1177/102986490601000109
Autor:
Dennis N. Jumbam, Amal Noureldeen, Jürgen Kraus, Michael Ochse, Gerhard Bringmann, Andreas Hamm
Publikováno v:
European Journal of Organic Chemistry. 2001:1983-1987
The iridoid alkaloid gardenamide A (3) was isolated from the phytochemically uninvestigated East African Rubiaceae species Rothmannia urcelliformis (Hiern) Bullock. Its absolute stereostructure was determined by quantum chemical CD calculations, whic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54e24892c7a4e29c5da3f14fdc7e064e
https://doi.org/10.1002/1099-0690(200105)2001:10<1983::aid-ejoc1983>3.0.co
https://doi.org/10.1002/1099-0690(200105)2001:10<1983::aid-ejoc1983>3.0.co
Autor:
Markus Heubes, and Bernd Schöner, Michael Ochse, O. Schupp, Matthias Breuning, Lothar Göbel, Gerhard Bringmann
Publikováno v:
The Journal of Organic Chemistry. 65:722-728
Configurationally unstable biaryl lactones of type (M)-1 ⇌ (P)-1 and ring-opened 2-acyl-2‘-hydroxy biaryl compounds of type (M)-4 ⇌ (P)-4 are versatile precursors for the atroposelective preparation of axially chiral biaryls. The activation bar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::853e4ad0841588d346cd5b310abd6713
https://doi.org/10.1021/jo9913356
https://doi.org/10.1021/jo9913356
Publikováno v:
Tetrahedron. 56:581-585
The total synthesis of the N-quaternary isoquinoline alkaloid gentrymine B (1) and of its unnatural enantiomer as well as its oxidative degradation is described. A further proof of stereostructure and hints at the biosynthetic origin of the unusual S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c513be3b83d9006061ec1e024bfe6525
https://doi.org/10.1016/s0040-4020(99)01054-6
https://doi.org/10.1016/s0040-4020(99)01054-6
Autor:
Orde Q. Munro, Niyum Ramesar, Gerhard Bringmann, Siegfried E. Drewes, Eva-Maria Peters, Karl Peters, Marion M. Horn, Michael Ochse
Publikováno v:
Phytochemistry. 50:387-394
From the leaves of Burchellia bubalina (Rubiaceae) pure P- and a-gardiol have been isolated, the latter in crystalline form for the first time. X-ray analysis of P-gardiol establishes its relative configuration. Treatment of the tosyl derivative of P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f023686d3c015250dd88ca5c029b0c9
https://doi.org/10.1016/s0031-9422(98)00508-1
https://doi.org/10.1016/s0031-9422(98)00508-1
Publikováno v:
Planta Medica. 63:544-547
The first synthesis of an N-quaternary salt of a naphthylisoquinoline alkaloid, N,N-dimethyldioncophyllinium A iodide, is described. For this potential natural product, a degradative procedure for the unambiguous stereoanalysis of the stereogenic cen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8601036c78addf933277dc5a0bd08a97
https://doi.org/10.1055/s-2006-957760
https://doi.org/10.1055/s-2006-957760
Autor:
Siefried E. Drewes, Karl Peters, Niyum Ramesar, Eva-Maria Peters, Gerhard Bringmann, Michael Ochse, Orde Q. Munro, Marion M. Horn
Publikováno v:
ChemInform. 30
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b8e8f44f25eca22068711c7ab0017de
https://doi.org/10.1002/chin.199920218
https://doi.org/10.1002/chin.199920218