Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Michael Obrecht"'
Autor:
Michael Obrecht, Stefan Zurbruegg, Nathalie Accart, Christian Lambert, Arno Doelemeyer, Birgit Ledermann, Nicolau Beckmann
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
The 3Rs principles—reduction, refinement, replacement—are at the core of preclinical research within drug discovery, which still relies to a great extent on the availability of models of disease in animals. Minimizing their distress, reducing the
Externí odkaz:
https://doaj.org/article/9555f460d3f64bb6ac866e3ea49e2a90
Autor:
Nathalie Accart, Janet Dawson, Michael Obrecht, Christian Lambert, Manuela Flueckiger, Julie Kreider, Shinji Hatakeyama, Peter J. Richards, Nicolau Beckmann
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The objective of this work was to assess the consequences of repeated intra-articular injection of monosodium urate (MSU) crystals with inflammasome priming by lipopolysaccharide (LPS) in order to simulate recurrent bouts of gout in rats. Tr
Externí odkaz:
https://doaj.org/article/6ccf86dc007b45ae93bccbf17995c98e
Autor:
Giulio Morozzi, Julian Rothen, Gauthier Toussaint, Katrina De Lange, Katrin Westritschnig, Arno Doelemeyer, Vanessa Pitiot Ueberschlag, Peter Kahle, Christian Lambert, Michael Obrecht, Nicolau Beckmann, Veronique Ritter, Moh Panesar, Daniela Stauffer, Isabelle Garnier, Matthias Mueller, Danilo Guerini, Caroline Gubser Keller, Judith Knehr, Guglielmo Roma, Michael Bidinosti, Sophie Brachat, Frederic Morvan, Mara Fornaro
Publikováno v:
iScience, Vol 24, Iss 12, Pp 103434- (2021)
Summary: Inflammatory responses are crucial for regeneration following peripheral nerve injury (PNI). PNI triggers inflammatory responses at the site of injury. The DNA-sensing receptor cyclic GMP-AMP synthase (cGAS) and its downstream effector stimu
Externí odkaz:
https://doaj.org/article/34f8e9f03cac483cb7ab6b1f71128e9e
Autor:
Elisa Giorgetti, Moh Panesar, Yunyu Zhang, Stefanie Joller, Marie Ronco, Michael Obrecht, Christian Lambert, Nathalie Accart, Nicolau Beckmann, Arno Doelemeyer, Ludovic Perrot, Isabelle Fruh, Matthias Mueller, Eliane Pierrel, Serge Summermatter, Michael Bidinosti, Derya R. Shimshek, Sophie Brachat, Mark Nash
Publikováno v:
Cell Reports, Vol 29, Iss 6, Pp 1539-1554.e7 (2019)
Summary: Age-related loss of skeletal muscle innervation by motor neurons leads to impaired neuromuscular function and is a well-established clinical phenomenon. However, the underlying pathogenesis remains unclear. Studying mice, we find that the nu
Externí odkaz:
https://doaj.org/article/13d82a5330874e21a85e5781c1bb0dd9
Autor:
Enrica Saponara, Carlos Penno, Vanessa Orsini, Zhong-Yi Wang, Audrey Fischer, Alexandra Aebi, Meztli L. Matadamas-Guzman, Virginie Brun, Benoit Fischer, Margaret Brousseau, Peter O'Donnell, Jonathan Turner, Alexandra Graff Meyer, Laura Bollepalli, Giovanni d’Ario, Guglielmo Roma, Walter Carbone, Stefano Annunziato, Michael Obrecht, Nicolau Beckmann, Chandra Saravanan, Arnaud Osmont, Philipp Tropberger, Shola M. Richards, Christel Genoud, Svenja Ley, Iwona Ksiazek, Florian Nigsch, Luigi M. Terracciano, Heiko S. Schadt, Tewis Bouwmeester, Jan S. Tchorz, Heinz Ruffner
Publikováno v:
The American journal of pathology.
The roof plate-specific spondin-leucine-rich repeat-containing G-protein-coupled receptor 4/5 (Lgr4/5)-zinc and ring finger 3/ring finger protein 43 module is a master regulator of hepatic Wnt/β-catenin signaling and metabolic zonation, but its impa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb7c1c4c6570641d2e5408b53b241d56
https://pubmed.ncbi.nlm.nih.gov/36410420
https://pubmed.ncbi.nlm.nih.gov/36410420
Autor:
Arnaud Osmont, Walter Carbone, Vanessa Orsini, Florian Nigsch, Jonathan J. Turner, Christel Genoud, Shola M Richards, Laura Bollepalli, Enrica Saponara, Svenja Ley, Zhong-Yi Wang, Giovanni d'Ario, Alexandra Aebi, Meztli L Matadamas Guzmán, Philipp Tropberger, Stefano Annunziato, Chandrassegar Saravanan, Benoit Fischer, Guglielmo Roma, Tewis Bouwmeester, Michael Obrecht, Jan S. Tchorz, Virginie Brun, Heinz Ruffner, Nicolau Beckmann, Carlos A. Penno, Margaret E. Brousseau, Peter O'Donnell, Alexandra Graff Meyer, Iwona Ksiazek, Luigi Terraciano
Background & AimsThe Rspo-Lgr4/5-Znrf3/Rnf43 module is a master regulator of hepatic Wnt/β-catenin signaling and metabolic zonation, but its impact on nonalcoholic fatty liver disease (NAFLD) remains unclear. We studied whether liver-specific loss o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a28cc1cd150989852141c4658c7ee558
https://doi.org/10.1101/2021.11.22.469602
https://doi.org/10.1101/2021.11.22.469602
Autor:
Sophie Brachat, Danilo Guerini, Nicolau Beckmann, Isabelle Garnier, Veronique Ritter, Vanessa Pitiot Ueberschlag, Daniela Stauffer, Giulio Morozzi, Frederic Morvan, Katrin Westritschnig, Gauthier Toussaint, Julian Rothen, Judith Knehr, Michael Obrecht, Peter Kahle, Michael Bidinosti, Mara Fornaro, Matthias Mueller, Arno Doelemeyer, Katrina De Lange, Caroline Gubser Keller, Moh Panesar, Christian Lambert, Guglielmo Roma
Publikováno v:
iScience
iScience, Vol 24, Iss 12, Pp 103434-(2021)
iScience, Vol 24, Iss 12, Pp 103434-(2021)
Summary Inflammatory responses are crucial for regeneration following peripheral nerve injury (PNI). PNI triggers inflammatory responses at the site of injury. The DNA-sensing receptor cyclic GMP-AMP synthase (cGAS) and its downstream effector stimul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd7a2ef1b44038de9103a961edc3d92
http://europepmc.org/articles/PMC8633968
http://europepmc.org/articles/PMC8633968
Autor:
Nathalie Accart, Janet Dawson, Nicolau Beckmann, Julie Kreider, Michael Obrecht, Shinji Hatakeyama, Christian Lambert, Manuela Flueckiger, Peter Richards
Publikováno v:
Scientific Reports
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Effects of repeated injection of monosodium urate (MSU) crystals, in combination with lipopolysaccharide (LPS), into rat knee joints every two weeks for a maximum of five administrations were investigated. Joint swelling, nociception and hard/soft ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41efec2f297d76e35a9329eb489e78cd
https://doi.org/10.21203/rs.3.rs-758047/v1
https://doi.org/10.21203/rs.3.rs-758047/v1
Autor:
Arno Doelemeyer, Michael Obrecht, Moh Panesar, Marie Ronco, Nathalie Accart, Christian Lambert, Elisa Giorgetti, Mark Nash, Michael Bidinosti, Nicolau Beckmann
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-18 (2019)
Scientific Reports
Scientific Reports
Assessment of myelin integrity in peripheral nerve injuries and pathologies has largely been limited to post-mortem analysis owing to the difficulty in obtaining biopsies without affecting nerve function. This is further encumbered by the small size
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08902549bf90bcf674b4b85b706aee87
http://link.springer.com/article/10.1038/s41598-019-49850-2
http://link.springer.com/article/10.1038/s41598-019-49850-2
Autor:
Marjorie Berger, Michael Obrecht, Nicolau Beckmann, Stephane Ferretti, Michael Rugaard Jensen, Laura Holzer
Publikováno v:
Cancer Research. 78:2111-2111
Rapid development in nanotechnology allows the incorporation of multiple therapeutic agents (e.g. liposomes) into nanoparticle with a size range from 1 to 1000 nm. These nanocarrier systems provide new approaches to treat aggressive malignancy. Nano-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bad54213534fac631720a1fe85f7cc80
https://doi.org/10.1158/1538-7445.am2018-2111
https://doi.org/10.1158/1538-7445.am2018-2111