Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Michael O. Ports"'
Autor:
Michael O. Ports, Ruth A. Salmon, Blythe Sather, Heidi K. Jessup, Christopher R. Clouser, Lindsey Wimberly, Yue Jiang, Ronald J. Hause, David Kugler, Timothy G. Johnstone, Patrick Carlson, Wendy Curtis, Jon C. Jones, Alex Baturevych, Catherine Sierra, Collin Hauskins, Neha Soni, Melissa Works
Supplementary Figure 1 shows information about the differential effects of lenalidomide with additional scfvs and the selected scfv at an additional E:T ratio with OPM-2 and RPMI-8226 cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d0afc0464e3243fd418c73786778cf
https://doi.org/10.1158/1535-7163.22506366
https://doi.org/10.1158/1535-7163.22506366
Autor:
Michael O. Ports, Ruth A. Salmon, Blythe Sather, Heidi K. Jessup, Christopher R. Clouser, Lindsey Wimberly, Yue Jiang, Ronald J. Hause, David Kugler, Timothy G. Johnstone, Patrick Carlson, Wendy Curtis, Jon C. Jones, Alex Baturevych, Catherine Sierra, Collin Hauskins, Neha Soni, Melissa Works
Anti–B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T cells have shown promising clinical responses in patients with relapsed/refractory multiple myeloma. Lenalidomide, an immunomodulatory drug, potentiates T cell functionality, d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec1de428704b5d6bdfb9b182aec9e142
https://doi.org/10.1158/1535-7163.c.6538380.v1
https://doi.org/10.1158/1535-7163.c.6538380.v1
Autor:
Michael O. Ports, Ruth A. Salmon, Blythe Sather, Heidi K. Jessup, Christopher R. Clouser, Lindsey Wimberly, Yue Jiang, Ronald J. Hause, David Kugler, Timothy G. Johnstone, Patrick Carlson, Wendy Curtis, Jon C. Jones, Alex Baturevych, Catherine Sierra, Collin Hauskins, Neha Soni, Melissa Works
anti-BCMA CAR T amino acid sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b406a8728513acff0fe733a8adcb7e7
https://doi.org/10.1158/1535-7163.22506351.v1
https://doi.org/10.1158/1535-7163.22506351.v1
Autor:
Michael O. Ports, Ruth A. Salmon, Blythe Sather, Heidi K. Jessup, Christopher R. Clouser, Lindsey Wimberly, Yue Jiang, Ronald J. Hause, David Kugler, Timothy G. Johnstone, Patrick Carlson, Wendy Curtis, Jon C. Jones, Alex Baturevych, Catherine Sierra, Collin Hauskins, Neha Soni, Melissa Works
Supplementary Figure 4 shows the effects of lenalidomide on CD27, CCR7, CD45RA, and CAR positivity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1925681cdee8d90e38f67e48891705e4
https://doi.org/10.1158/1535-7163.22506357.v1
https://doi.org/10.1158/1535-7163.22506357.v1
Autor:
Michael O. Ports, Ruth A. Salmon, Blythe Sather, Heidi K. Jessup, Christopher R. Clouser, Lindsey Wimberly, Yue Jiang, Ronald J. Hause, David Kugler, Timothy G. Johnstone, Patrick Carlson, Wendy Curtis, Jon C. Jones, Alex Baturevych, Catherine Sierra, Collin Hauskins, Neha Soni, Melissa Works
Supplementary Figure 2 shows the effect of lenalidomide on BCMA expression of the cell lines used in the experiments in this manuscript.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03c42d08c0f6db0e0ef235edfd100324
https://doi.org/10.1158/1535-7163.22506363.v1
https://doi.org/10.1158/1535-7163.22506363.v1
Autor:
Michael O. Ports, Ruth A. Salmon, Blythe Sather, Heidi K. Jessup, Christopher R. Clouser, Lindsey Wimberly, Yue Jiang, Ronald J. Hause, David Kugler, Timothy G. Johnstone, Patrick Carlson, Wendy Curtis, Jon C. Jones, Alex Baturevych, Catherine Sierra, Collin Hauskins, Neha Soni, Melissa Works
Supplementary Figure 3 shows the effect of lenalidomide on cytokine production by anti-BCMA CAR T cells stimulated with BCMA beads for 24 hours.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e7b4172afe6d412aa4e8eaacba36b43
https://doi.org/10.1158/1535-7163.22506360.v1
https://doi.org/10.1158/1535-7163.22506360.v1
Autor:
Michael O. Ports, Ruth A. Salmon, Blythe Sather, Heidi K. Jessup, Christopher R. Clouser, Lindsey Wimberly, Yue Jiang, Ronald J. Hause, David Kugler, Timothy G. Johnstone, Patrick Carlson, Wendy Curtis, Jon C. Jones, Alex Baturevych, Catherine Sierra, Collin Hauskins, Neha Soni, Melissa Works
Supplementary Methods and Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54ed1b249766c63e611f54d59f8c8051
https://doi.org/10.1158/1535-7163.22506354.v1
https://doi.org/10.1158/1535-7163.22506354.v1
Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation
Autor:
Julie Farand, Jeffrey E. Kropf, Peter Blomgren, Jianjun Xu, Aaron C. Schmitt, Zachary E. Newby, Ting Wang, Eisuke Murakami, Ona Barauskas, Jawahar Sudhamsu, Joy Y. Feng, Anita Niedziela-Majka, Brian E. Schultz, Karen Schwartz, Serge Viatchenko-Karpinski, Dmytro Kornyeyev, Adam Kashishian, Peidong Fan, Xiaowu Chen, Eric B. Lansdon, Michael O. Ports, Kevin S. Currie, William J. Watkins, Gregory T. Notte
Publikováno v:
ACS Med Chem Lett
[Image: see text] We describe the discovery of three structurally differentiated potent and selective MTH1 inhibitors and their subsequent use to investigate MTH1 as an oncology target, culminating in target (in)validation. Tetrahydronaphthyridine 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a8664fe5cf60201d9c5d872c2fbdf25
https://europepmc.org/articles/PMC7074220/
https://europepmc.org/articles/PMC7074220/
Autor:
Famke Aeffner, G. David Young, Maryam Jangani, Mirza Peljto, Joseph S. Krueger, Joshua C. Black, Justin K Major, Michael O Ports, Nathan T. Martin
Publikováno v:
Laboratory investigation; a journal of technical methods and pathology. 96(12)
Tissue image analysis (tIA) is emerging as a powerful tool for quantifying biomarker expression and distribution in complex diseases and tissues. Pancreatic ductal adenocarcinoma (PDAC) develops in a highly complex and heterogeneous tissue environmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5701b87d11fb75743523e535adffb63
https://pubmed.ncbi.nlm.nih.gov/27775692
https://pubmed.ncbi.nlm.nih.gov/27775692
Autor:
Ingrid Kuikman, Marcel Raspe, Arnoud Sonnenberg, Sandy H.M. Litjens, Kevin Wilhelmsen, Michael O. Ports, Evelyne Frijns, Kees Jalink
Publikováno v:
Molecular Biology of the Cell
T1736 is a novel phosphorylation site on the integrin β4 subunit that is phosphorylated downstream of protein kinase C and EGF receptor activation and is a substrate for protein kinase D1 in vitro and in cells. It contributes to the regulation of HD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8245b7aa4d49200f807efb78302b5c76
https://pubmed.ncbi.nlm.nih.gov/22357621
https://pubmed.ncbi.nlm.nih.gov/22357621