Výsledky vyhledávání - "Michael O. Idowu"

Akademický článek

Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma

Autor: Kranthi Kumar Chougoni, Haemin Park, Priyadarshan K. Damle, Travis Mason, Bo Cheng, Martin M. Dcona, Barbara Szomju, Mikhail G. Dozmorov, Michael O. Idowu, Steven R. Grossman

Publikováno v: Oncogenesis, Vol 12, Iss 1, Pp 1-8 (2023)

Abstract There is a critical need to identify new therapeutic vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). Transcriptional co-regulators C-terminal binding proteins (CtBP) 1 and 2 are highly overexpressed in human PDAC, and CRISPR-base

Externí odkaz: https://doaj.org/article/ab4a0b9b5c2c463eaffaa9924dadd679

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Akademický článek

The crosstalking immune cells network creates a collective function beyond the function of each cellular constituent during the progression of hepatocellular carcinoma

Autor: Nicholas Koelsch, Faridoddin Mirshahi, Hussein F. Aqbi, Mulugeta Saneshaw, Michael O. Idowu, Amy L. Olex, Arun J. Sanyal, Masoud H. Manjili

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)

Abstract Abundance of data on the role of inflammatory immune responses in the progression or inhibition of hepatocellular carcinoma (HCC) has failed to offer a curative immunotherapy for HCC. This is largely because of focusing on detailed specific

Externí odkaz: https://doaj.org/article/b445faca8cc44241a8a690ae830ee44f

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Akademický článek

The human intermediate prolactin receptor is a mammary proto-oncogene

Autor: Jacqueline M. Grible, Patricija Zot, Amy L. Olex, Shannon E. Hedrick, J. Chuck Harrell, Alicia E. Woock, Michael O. Idowu, Charles V. Clevenger

Publikováno v: npj Breast Cancer, Vol 7, Iss 1, Pp 1-11 (2021)

Abstract The hormone prolactin (PRL) and its receptor (hPRLr) are significantly involved in breast cancer pathogenesis. The intermediate hPRLr (hPRLrI) is an alternatively-spliced isoform, capable of stimulating cellular viability and proliferation.

Externí odkaz: https://doaj.org/article/4c18855c6cd74555a97c5428cf615799

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Akademický článek

Local and distant tumor dormancy during early stage breast cancer are associated with the predominance of infiltrating T effector subsets

Autor: Hussein F. Aqbi, Cara Coleman, Melika Zarei, Saeed H. Manjili, Laura Graham, Jennifer Koblinski, Chunquing Guo, Yibin Xie, Georgi Guruli, Harry D. Bear, Michael O. Idowu, Mehran Habibi, Xiang-Yang Wang, Masoud H. Manjili

Publikováno v: Breast Cancer Research, Vol 22, Iss 1, Pp 1-15 (2020)

Abstract Background Although breast cancer mortality is a result of distant recurrences associated with the establishment of tumor dormancy, current clinical practice guidelines recommend a wait and watch approach for tumor recurrences. This is becau

Externí odkaz: https://doaj.org/article/76d63ae0d42147fd870e77928dba6454

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Akademický článek

Metabolomic‐based noninvasive serum test to diagnose nonalcoholic steatohepatitis: Results from discovery and validation cohorts

Publikováno v: Hepatology Communications, Vol 2, Iss 7, Pp 807-820 (2018)

Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic liver disease worldwide and includes a broad spectrum of histologic phenotypes, ranging from simple hepatic steatosis or nonalcoholic fatty liver (NAFL) to nonalcoholic steat

Externí odkaz: https://doaj.org/article/3db3e565d647480a965ad1c11a5f01be

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Akademický článek

Regulatory T Cells Control the Switch From in situ to Invasive Breast Cancer

Autor: Leandro M. Martinez, Valentina Robila, Nicholas M. Clark, Wei Du, Michael O. Idowu, Melanie R. Rutkowski, Paula D. Bos

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Ductal carcinoma in situ (DCIS) is a non-obligate precursor of breast cancer, and it only progresses to invasive breast cancer in around 40% of patients. While immune infiltrates have been observed in these early cancer lesions, their potential progn

Externí odkaz: https://doaj.org/article/8ff76fd244e84430b3b5ee682c73df14

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Akademický článek

Non-Cell Autonomous Effects of the Senescence-Associated Secretory Phenotype in Cancer Therapy

Autor: Tareq Saleh, Liliya Tyutynuk-Massey, Emmanuel K. Cudjoe, Michael O. Idowu, Joseph W. Landry, David A. Gewirtz

Publikováno v: Frontiers in Oncology, Vol 8 (2018)

In addition to promoting various forms of cell death, most conventional anti-tumor therapies also promote senescence. There is now extensive evidence that therapy-induced senescence (TIS) might be transient, raising the concern that TIS could represe

Externí odkaz: https://doaj.org/article/0b9798c39d2e4f999d0aff471e35555f

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Akademický článek

Evaluating Nonclinical Performance of the Academic Pathologist

Autor: Austin Blackburn Wiles MD, Michael O. Idowu MD, MPH, Charles V. Clevenger MD, PhD, Celeste N. Powers MD, PhD

Publikováno v: Academic Pathology, Vol 5 (2018)

Academic pathologists perform clinical duties, as well as valuable nonclinical activities. Nonclinical activities may consist of research, teaching, and administrative management among many other important tasks. While clinical duties have many clear

Externí odkaz: https://doaj.org/article/37f16757d2ec4ed0b786a318e7c251cc

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