Zobrazeno 1 - 10
of 81
pro vyhledávání: '"Michael O. Frederick"'
Autor:
Ting Wan, Zhenghui Wen, Gabriele Laudadio, Luca Capaldo, Rob Lammers, Juan A. Rincón, Pablo García-Losada, Carlos Mateos, Michael O. Frederick, Rémy Broersma, Timothy Noël
Publikováno v:
ACS Central Science, Vol 8, Iss 1, Pp 51-56 (2021)
Externí odkaz:
https://doaj.org/article/f0b40780e1294bb7831c474c3489dcab
Autor:
Benjamin Cohen, Dan Lehnherr, Melda Sezen-Edmonds, Jacob H. Forstater, Michael O. Frederick, Lin Deng, Antonio C. Ferretti, Kaid Harper, Moiz Diwan
Publikováno v:
Chemical Engineering Research and Design. 192:622-637
Autor:
Carlos Mateos, Juan A. Rincón, Michael O. Frederick, Timothy Noël, Pablo Garcia-Losada, Gabriele Laudadio, Ting Wan, Luca Capaldo, Alexander V. Nyuchev, Manuel Nuño
Publikováno v:
Angewandte Chemie, 133(33), 18037-18041. John Wiley and Sons Ltd
Angewandte Chemie, International Edition, 60(33), 17893-17897. John Wiley and Sons Ltd
Angewandte Chemie International Edition
Angewandte Chemie, International Edition, 60(33), 17893-17897. John Wiley and Sons Ltd
Angewandte Chemie International Edition
Photocatalytic hydrogen atom transfer is a very powerful strategy for the regioselective C(sp3)-H functionalization of organic molecules. Herein, we report on the unprecedented combination of decatungstate hydrogen atom transfer photocatalysis with t
Autor:
Han Xia, Stephen R. Groskreutz, Michael O. Frederick, Michael E. Kopach, Nessa Mullane, Jeffrey T. Lampert, Kevin D. Seibert, Mark A. Strege, Neil J. Kallman, Bradley M. Campbell, Sergey V. Tsukanov, Frank L. Torres Torres, Ashley A. Humenik, Gordon R. Lambertus, Nil Tandogan, Nicholas D. Klitzing, Carmel Condon, Shujauddin M. Changi, Joel R. Calvin, Jennifer McClary Groh, Timothy M. Braden, Marie E. O’Mahony, Juliana Kretsinger, Rachel N. Richey, Stephanie R. Coffin, Laura M. Maguire, Richard D. Spencer, Raymond A. Boyse, Zachary D. Harms, John D. Murphy, Humphrey A. Moynihan, Olivia Gowran
Publikováno v:
Organic Process Research & Development. 25:1628-1636
Autor:
Fabiola Fanini, Alberto Luridiana, Daniele Mazzarella, Antonella Ilenia Alfano, Perry van der Heide, Juan A. Rincón, Pablo García-Losada, Carlos Mateos, Michael O. Frederick, Manuel Nuño, Timothy Noël
Publikováno v:
Tetrahedron Letters. 117:154380
Autor:
Hao Sun, Michael O. Frederick, Roger Ryan Rothhaar, Amy C. DeBaillie, Brian Morgan Watson, Carlos Mateos, Leonard L. Winneroski, Carlos Jaramillo, Talbi Kaoudi, Matthew Johnson, Pablo Garcia-Losada, Srinivas Gangula, Peter J. Lindsay-Scott, Steven James Green, Dustin J. Mergott, Dajiang Jing, Marvin M. Hansen, José Eugenio de Diego, Juan A. Rincón, Kevin D. Seibert, Lei Zhang, Jiuyuan Li
Publikováno v:
Organic Process Research & Development. 24:306-314
Herein we report a summary of the synthetic development of LY3202626 from the initial discovery route to a final route that was scaled to make 150 kg. Key developments include the use of a [3 + 2] ...
Autor:
Ting, Wan, Luca, Capaldo, Gabriele, Laudadio, Alexander V, Nyuchev, Juan A, Rincón, Pablo, García-Losada, Carlos, Mateos, Michael O, Frederick, Manuel, Nuño, Timothy, Noël
Publikováno v:
Angewandte Chemie (International Ed. in English)
Photocatalytic hydrogen atom transfer is a very powerful strategy for the regioselective C(sp3)–H functionalization of organic molecules. Herein, we report on the unprecedented combination of decatungstate hydrogen atom transfer photocatalysis with
Autor:
Michael O. Frederick, Michael P. Carroll, Olivia Gowran, Mark A. Pietz, Michael M. Murray, Eoin M. Wilson, Harold Moloney, Aoibheann O’Connor, Douglas Patton Kjell, C. Brad Held
Publikováno v:
Organic Process Research & Development. 23:2549-2555
A new synthesis for an intermediate of abemaciclib is described. Keys to this route are the use of inexpensive starting materials, biphasic amine alkylation for mild C–N bond formation, anhydrous c...
Autor:
Song Lin, Michael O. Frederick, Niankai Fu, Brian G. Ernst, Robert A. DiStasio, Lu Song, Wai Hang Lee
Publikováno v:
Nature chemistry
Chiral nitriles and their derivatives are prevalent in pharmaceuticals and bioactive compounds. Enantioselective alkene hydrocyanation represents a convenient and efficient approach for synthesizing these molecules. However, a generally applicable me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee8b490251a0efa27e163b6a4dc9504d
https://doi.org/10.26434/chemrxiv.9784625
https://doi.org/10.26434/chemrxiv.9784625
Autor:
Michael O. Frederick, Kurt T. Lorenz, Michael E. LeTourneau, Martin D. Johnson, Richard D. Miller, Lauren E. Cziesla, Todd D. Maloney, Richard F. Cope, Joel R. Calvin, Yangwei John Pu
Publikováno v:
Organic Process Research & Development. 19:1411-1417
An NH4Cl-catalyzed ethoxy ethyl deprotection was developed for the synthesis of merestinib, a MET inhibitor. Alternative reactor technologies using temperatures above the solvent boiling point are combined with this mild catalyst to promote the depro