Zobrazeno 1 - 10
of 389
pro vyhledávání: '"Michael O Thorner"'
Autor:
Chun-Xia Yi, Kristy M Heppner, Henriette Kirchner, Jenny Tong, Maximillian Bielohuby, Bruce D Gaylinn, Timo D Müller, Erin Bartley, Harold W Davis, Yongmei Zhao, Anupama Joseph, Traci Kruthaupt, Nickki Ottaway, Dhiraj Kabra, Kirk M Habegger, Stephen C Benoit, Martin Bidlingmaier, Michael O Thorner, Diego Perez-Tilve, Matthias H Tschöp, Paul T Pfluger
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32100 (2012)
OBJECTIVE:Ghrelin acylation by ghrelin O-acyltransferase (GOAT) has recently been reported to be essential for the prevention of hypoglycemia during prolonged negative energy balance. Using a unique set of four different genetic loss-of-function mode
Externí odkaz:
https://doaj.org/article/bc467b72b5ea464ba3c01bca6c8e1ed1
Autor:
Michael O Thorner
Publikováno v:
Frontiers in Endocrinology, Vol 1 (2010)
Externí odkaz:
https://doaj.org/article/b551c117d31448799da3f2695967ac6f
Autor:
Mohammadreza Pakseresht, Carla M. Prado, Michael Freemark, Bruce D. Gaylinn, Michael O. Thorner, Catherine J. Field, Michelle L. Mackenzie, Maha Alsaif, Andrea M. Haqq
Publikováno v:
Clinical Endocrinology. 93:579-589
Background The effects of dietary macronutrients on orexigenic and anorexigenic hormones in children are poorly understood. Objective To explore effects of varying dietary macronutrients on appetite-regulating hormones [acyl ghrelin (AG) and desacyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72bd4983469edc4cb8bfdcfb34d9fd4b
https://doi.org/10.1111/cen.14279
https://doi.org/10.1111/cen.14279
Publikováno v:
Journal of the Endocrine Society. 5
Context We hypothesize, based on the degree of residual hypothalamic-pituitary function, that some, but not all, children with growth hormone deficiency (GHD) may have beneficial growth responses to the orally administered growth hormone (GH) secreta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c0e20c0d5a44ff48d9353b3ef8b77caf
https://doi.org/10.1210/jendso/bvab030
https://doi.org/10.1210/jendso/bvab030
Autor:
Michael O. Thorner, Haiying Chen, John C. McKew, George M Bright, Minh-Ha T Do, Werner F. Blum
Publikováno v:
Journal of the Endocrine Society
Context Recombinant human growth hormone (rhGH) is approved for treatment of pediatric growth hormone deficiency (GHD), with greatest growth responses observed in those with severe GHD. Orally administered GH secretagogues (GHS) may be useful treatme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a971f31eb9636c61e08152fb71bc36
https://pubmed.ncbi.nlm.nih.gov/34141995
https://pubmed.ncbi.nlm.nih.gov/34141995
Publikováno v:
Journal of the Endocrine Society
Presentation Type: OralScience Type and Topic: Clinical Trial Introduction: LUM-201 (ibutamoren, formerly MK-0677) is an orally administered GH-secretagogue that stimulates the GH secretagogue receptor (GHSR1a) in the hypothalamus and pituitary. LUM-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15ae457952a59a00e988e56bbf44086
http://europepmc.org/articles/PMC8265876
http://europepmc.org/articles/PMC8265876
Publikováno v:
Nephrology Dialysis Transplantation. 33:523-530
BACKGROUND: Protein-energy wasting (PEW) in end-stage renal disease (ESRD) patients is associated with increased morbidity and mortality, but options for treatment are limited. Growth hormone (GH) increases insulin-like growth factor 1 (IGF-1), with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::388775b8d667f1f12f69c7e4aaaeec94
https://doi.org/10.1093/ndt/gfw474
https://doi.org/10.1093/ndt/gfw474
Autor:
Edward H. Oldfield, David E. Bruns, Min Yu, Michael O. Thorner, Ralf Nass, John A. Jane, Mary Lee Vance
Publikováno v:
Clinical Chemistry. 63:486-494
BACKGROUND In the immediate postoperative period following resection of growth hormone (GH)-secreting pituitary tumors, serum concentrations of GH have limited ability to predict remission of acromegaly. Since many actions of GH actions are mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af8f9cbad8bf4a2312c53596284650d
https://doi.org/10.1373/clinchem.2016.262592
https://doi.org/10.1373/clinchem.2016.262592
Autor:
Michael O. Thorner, Carrie L. Pledger, John A. Jane, Edward H. Oldfield, Jason P. Sheehan, Mary Lee Vance
Publikováno v:
Journal of Neurosurgery. 126:1959-1966
OBJECTIVEThe relationship between growth hormone (GH) and insulin-like growth factor–1 (IGF-1) in patients with acromegaly as serial levels drop over time after treatment has not been examined previously. Knowledge of this relationship is important
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41c3d01257acd2e16ec1427e1f475ea7
https://doi.org/10.3171/2016.8.jns161123
https://doi.org/10.3171/2016.8.jns161123
Autor:
Paul Saenger, Gudmundur Johannsson, David B. Dunger, Anita C. S. Hokken-Koelega, Philippe Backeljauw, Stefano Cianfarani, Pinchas Cohen, Margaret C. S. Boguszewski, Martin R. Pollak, Claire E Higham, Andrew R. Hoffman, Pia Burman, Christian J. Strasburger, Lars Sävendahl, Richard J. Ross, John S. Fuqua, Ken K. Y. Ho, Sally Radovick, Anders Juul, David B. Allen, Anthony J. Swerdlow, Jens Sandahl Christiansen, Martin Bidlingmaier, Kazuo Chihara, Gary Butler, Peter A. Lee, H. Toft Sorensen, Eva Marie Erfurth, Cheri Deal, John J. Kopchick, David R. Clemmons, Ron Rosenfeld, Adda Grimberg, Leslie L. Robison, Beverly M. K. Biller, Feyza Darendeliler, Kirstine Stochholm, Peter E. Clayton, Michael O. Thorner, Morey W. Haymond
Publikováno v:
European Journal of Endocrinology
European Journal of Endocrinology, 174(2), P1-P9. Bioscientifica Ltd
Allen, D B, Backeljauw, P, Bidlingmaier, M, Biller, B M K, Boguszewski, M, Burman, P, Butler, G, Chihara, K, Christiansen, J, Cianfarani, S, Clayton, P, Clemmons, D, Cohen, P, Darendeliler, F, Deal, C, Dunger, D, Erfurth, E M, Fuqua, J S, Grimberg, A, Haymond, M, Higham, C, Ho, K, Hoffman, A R, Hokken-Koelega, A, Johannsson, G, Juul, A, Kopchick, J, Lee, P, Pollak, M, Radovick, S, Robison, L, Rosenfeld, R, Ross, R J, Savendahl, L, Saenger, P, Toft Sorensen, H, Stochholm, K, Strasburger, C, Swerdlow, A & Thorner, M 2016, ' GH safety workshop position paper : a critical appraisal of recombinant human GH therapy in children and adults ', European Journal of Endocrinology, vol. 174, no. 2, pp. P1-9 . https://doi.org/10.1530/EJE-15-0873
European Journal of Endocrinology, 174(2), P1-P9. Bioscientifica Ltd
Allen, D B, Backeljauw, P, Bidlingmaier, M, Biller, B M K, Boguszewski, M, Burman, P, Butler, G, Chihara, K, Christiansen, J, Cianfarani, S, Clayton, P, Clemmons, D, Cohen, P, Darendeliler, F, Deal, C, Dunger, D, Erfurth, E M, Fuqua, J S, Grimberg, A, Haymond, M, Higham, C, Ho, K, Hoffman, A R, Hokken-Koelega, A, Johannsson, G, Juul, A, Kopchick, J, Lee, P, Pollak, M, Radovick, S, Robison, L, Rosenfeld, R, Ross, R J, Savendahl, L, Saenger, P, Toft Sorensen, H, Stochholm, K, Strasburger, C, Swerdlow, A & Thorner, M 2016, ' GH safety workshop position paper : a critical appraisal of recombinant human GH therapy in children and adults ', European Journal of Endocrinology, vol. 174, no. 2, pp. P1-9 . https://doi.org/10.1530/EJE-15-0873
Recombinant human GH (rhGH) has been in use for 30 years, and over that time its safety and efficacy in children and adults\ud has been subject to considerable scrutiny. In 2001, a statement from the GH Research Society (GRS) concluded that\ud ‘for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d72085ff55a71780d623f46bec044f2
https://doi.org/10.1530/eje-15-0873
https://doi.org/10.1530/eje-15-0873