Výsledky vyhledávání - "Michael O, Idowu"

Akademický článek

Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma

Autor: Kranthi Kumar Chougoni, Haemin Park, Priyadarshan K. Damle, Travis Mason, Bo Cheng, Martin M. Dcona, Barbara Szomju, Mikhail G. Dozmorov, Michael O. Idowu, Steven R. Grossman

Publikováno v: Oncogenesis, Vol 12, Iss 1, Pp 1-8 (2023)

Abstract There is a critical need to identify new therapeutic vulnerabilities in pancreatic ductal adenocarcinoma (PDAC). Transcriptional co-regulators C-terminal binding proteins (CtBP) 1 and 2 are highly overexpressed in human PDAC, and CRISPR-base

Externí odkaz: https://doaj.org/article/ab4a0b9b5c2c463eaffaa9924dadd679

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Akademický článek

The crosstalking immune cells network creates a collective function beyond the function of each cellular constituent during the progression of hepatocellular carcinoma

Autor: Nicholas Koelsch, Faridoddin Mirshahi, Hussein F. Aqbi, Mulugeta Saneshaw, Michael O. Idowu, Amy L. Olex, Arun J. Sanyal, Masoud H. Manjili

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-18 (2023)

Abstract Abundance of data on the role of inflammatory immune responses in the progression or inhibition of hepatocellular carcinoma (HCC) has failed to offer a curative immunotherapy for HCC. This is largely because of focusing on detailed specific

Externí odkaz: https://doaj.org/article/b445faca8cc44241a8a690ae830ee44f

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Akademický článek

The human intermediate prolactin receptor is a mammary proto-oncogene

Autor: Jacqueline M. Grible, Patricija Zot, Amy L. Olex, Shannon E. Hedrick, J. Chuck Harrell, Alicia E. Woock, Michael O. Idowu, Charles V. Clevenger

Publikováno v: npj Breast Cancer, Vol 7, Iss 1, Pp 1-11 (2021)

Abstract The hormone prolactin (PRL) and its receptor (hPRLr) are significantly involved in breast cancer pathogenesis. The intermediate hPRLr (hPRLrI) is an alternatively-spliced isoform, capable of stimulating cellular viability and proliferation.

Externí odkaz: https://doaj.org/article/4c18855c6cd74555a97c5428cf615799

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Akademický článek

Local and distant tumor dormancy during early stage breast cancer are associated with the predominance of infiltrating T effector subsets

Autor: Hussein F. Aqbi, Cara Coleman, Melika Zarei, Saeed H. Manjili, Laura Graham, Jennifer Koblinski, Chunquing Guo, Yibin Xie, Georgi Guruli, Harry D. Bear, Michael O. Idowu, Mehran Habibi, Xiang-Yang Wang, Masoud H. Manjili

Publikováno v: Breast Cancer Research, Vol 22, Iss 1, Pp 1-15 (2020)

Abstract Background Although breast cancer mortality is a result of distant recurrences associated with the establishment of tumor dormancy, current clinical practice guidelines recommend a wait and watch approach for tumor recurrences. This is becau

Externí odkaz: https://doaj.org/article/76d63ae0d42147fd870e77928dba6454

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Akademický článek

Alpha-1 Antitrypsin Inhibits Tumorigenesis and Progression of Colitis-Associated Colon Cancer through Suppression of Inflammatory Neutrophil-Activated Serine Proteases and IGFBP-3 Proteolysis

Autor: Qing Cai, Minsun Kim, Aki Harada, Michael O. Idowu, Gobalakrishnan Sundaresan, Jamal Zweit, Youngman Oh

Publikováno v: International Journal of Molecular Sciences, Vol 23, Iss 22, p 13737 (2022)

Colitis-associated colon cancer (CAC) accompanies the massive infiltration of neutrophils during tumorigenesis and progression of CAC. Depletion of neutrophils in circulation results in significant inhibition of tumor incidence in CAC. However, the u

Externí odkaz: https://doaj.org/article/e0b39b8fa86b45b4807050b0152e1df9

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Akademický článek

Metabolomic‐based noninvasive serum test to diagnose nonalcoholic steatohepatitis: Results from discovery and validation cohorts

Publikováno v: Hepatology Communications, Vol 2, Iss 7, Pp 807-820 (2018)

Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic liver disease worldwide and includes a broad spectrum of histologic phenotypes, ranging from simple hepatic steatosis or nonalcoholic fatty liver (NAFL) to nonalcoholic steat

Externí odkaz: https://doaj.org/article/3db3e565d647480a965ad1c11a5f01be

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Spatial Transcriptomic Analysis of a Diverse Patient Cohort Reveals a Conserved Architecture in Triple-Negative Breast Cancer

Autor: Rania Bassiouni, Michael O. Idowu, Lee D. Gibbs, Valentina Robila, Pamela J. Grizzard, Michelle G. Webb, Jiarong Song, Ashley Noriega, David W. Craig, John D. Carpten

Publikováno v: Cancer Res

Triple-negative breast cancer (TNBC) is an aggressive disease that disproportionately affects African American (AA) women. Limited targeted therapeutic options exist for patients with TNBC. Here, we employ spatial transcriptomics to interrogate tissu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d379d8019b25f19cdc32a34a72f2970c
https://doi.org/10.1158/0008-5472.can-22-2682

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Akademický článek

Regulatory T Cells Control the Switch From in situ to Invasive Breast Cancer

Autor: Leandro M. Martinez, Valentina Robila, Nicholas M. Clark, Wei Du, Michael O. Idowu, Melanie R. Rutkowski, Paula D. Bos

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

Ductal carcinoma in situ (DCIS) is a non-obligate precursor of breast cancer, and it only progresses to invasive breast cancer in around 40% of patients. While immune infiltrates have been observed in these early cancer lesions, their potential progn

Externí odkaz: https://doaj.org/article/8ff76fd244e84430b3b5ee682c73df14

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