Zobrazeno 1 - 10
of 180
pro vyhledávání: '"Michael Nothnagel"'
Autor:
Sophie A. Riesmeijer, Zoha Kamali, Michael Ng, Dmitriy Drichel, Bram Piersma, Kerstin Becker, Thomas B. Layton, Jagdeep Nanchahal, Michael Nothnagel, Ahmad Vaez, Hans Christian Hennies, Paul M. N. Werker, Dominic Furniss, Ilja M. Nolte
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Dupuytren’s disease (DD) is a highly heritable fibrotic disorder of the hand with incompletely understood etiology. A number of genetic loci, including Wnt signaling members, have been previously identified. Our overall aim was to identify
Externí odkaz:
https://doaj.org/article/1f6a94e13ec342bd8fe591da7584d1c3
Autor:
Nina Ishorst, Leonie Henschel, Frederic Thieme, Dmitriy Drichel, Sugirthan Sivalingam, Sarah L. Mehrem, Ariane C. Fechtner, Julia Fazaal, Julia Welzenbach, André Heimbach, Carlo Maj, Oleg Borisov, Jonas Hausen, Ruth Raff, Alexander Hoischen, Michael Dixon, Alvaro Rada‐Iglesias, Michaela Bartusel, Augusto Rojas‐Martinez, Khalid Aldhorae, Bert Braumann, Teresa Kruse, Christian Kirschneck, Gerrit Spanier, Heiko Reutter, Stefanie Nowak, Lina Gölz, Michael Knapp, Andreas Buness, Peter Krawitz, Markus M. Nöthen, Michael Nothnagel, Tim Becker, Kerstin U. Ludwig, Elisabeth Mangold
Publikováno v:
Molecular Genetics & Genomic Medicine, Vol 11, Iss 3, Pp n/a-n/a (2023)
Abstract Background Nonsyndromic cleft lip with/without cleft palate (nsCL/P) is a congenital malformation of multifactorial etiology. Research has identified >40 genome‐wide significant risk loci, which explain less than 40% of nsCL/P heritability
Externí odkaz:
https://doaj.org/article/205be1f83d914d678ac7257527a61a58
Autor:
Björn C. Frye, Karoline I. Gaede, Cesare Saltini, Milton D. Rossman, Dimitri S. Monos, Ken D. Rosenman, Christine R. Schuler, Ainsley Weston, Ralf Wegner, Rainer Noth, Gernot Zissel, Stefan Schreiber, Michael Nothnagel, Joachim Müller-Quernheim
Publikováno v:
Respiratory Research, Vol 22, Iss 1, Pp 1-5 (2021)
Abstract Sarcoidosis and chronic beryllium disease (CBD) are phenocopies, however the latter one has a clear trigger factor that is beryllium exposure. This study analyses single nucleotide polymorphisms (SNPs) in a large cohort for beryllium-exposed
Externí odkaz:
https://doaj.org/article/d2d9e6700fee494d99c00dad7931c246
Autor:
Bryan C. Quach, Michael J. Bray, Nathan C. Gaddis, Mengzhen Liu, Teemu Palviainen, Camelia C. Minica, Stephanie Zellers, Richard Sherva, Fazil Aliev, Michael Nothnagel, Kendra A. Young, Jesse A. Marks, Hannah Young, Megan U. Carnes, Yuelong Guo, Alex Waldrop, Nancy Y. A. Sey, Maria T. Landi, Daniel W. McNeil, Dmitriy Drichel, Lindsay A. Farrer, Christina A. Markunas, Jacqueline M. Vink, Jouke-Jan Hottenga, William G. Iacono, Henry R. Kranzler, Nancy L. Saccone, Michael C. Neale, Pamela Madden, Marcella Rietschel, Mary L. Marazita, Matthew McGue, Hyejung Won, Georg Winterer, Richard Grucza, Danielle M. Dick, Joel Gelernter, Neil E. Caporaso, Timothy B. Baker, Dorret I. Boomsma, Jaakko Kaprio, John E. Hokanson, Scott Vrieze, Laura J. Bierut, Eric O. Johnson, Dana B. Hancock
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
There is strong genetic evidence for cigarette smoking behaviors, yet little is known on nicotine dependence (ND). Here, the authors perform a genome-wide association study on ND in 58,000 smokers, identifying five genome-wide significant loci.
Externí odkaz:
https://doaj.org/article/508c732e509b4270b0f67aeb1af54d38
Autor:
Mahmoud Koko, Roland Krause, Thomas Sander, Dheeraj Reddy Bobbili, Michael Nothnagel, Patrick May, Holger Lerche
Publikováno v:
EBioMedicine, Vol 72, Iss , Pp 103588- (2021)
Background: Analyses of few gene-sets in epilepsy showed a potential to unravel key disease associations. We set out to investigate the burden of ultra-rare variants (URVs) in a comprehensive range of biologically informed gene-sets presumed to be im
Externí odkaz:
https://doaj.org/article/75699a2b380747bc94f6ea212dbb81c3
Autor:
Ben Krause-Kyora, Marcel Nutsua, Lisa Boehme, Federica Pierini, Dorthe Dangvard Pedersen, Sabin-Christin Kornell, Dmitriy Drichel, Marion Bonazzi, Lena Möbus, Peter Tarp, Julian Susat, Esther Bosse, Beatrix Willburger, Alexander H. Schmidt, Jürgen Sauter, Andre Franke, Michael Wittig, Amke Caliebe, Michael Nothnagel, Stefan Schreiber, Jesper L. Boldsen, Tobias L. Lenz, Almut Nebel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Leprosy, caused by infection with Mycobacterium leprae, was common in Europe in the Middle Ages. Here, Krause-Kyora et al. analyze ancient DNA from a medieval Danish leprosarium to assemble 10 complete bacterial genomes and perform association analys
Externí odkaz:
https://doaj.org/article/8fa5ee6a3c694f099a3d3800433d8665
Autor:
Corinna Ernst, Eric Hahnen, Christoph Engel, Michael Nothnagel, Jonas Weber, Rita K. Schmutzler, Jan Hauke
Publikováno v:
BMC Medical Genomics, Vol 11, Iss 1, Pp 1-10 (2018)
Abstract Background The use of next-generation sequencing approaches in clinical diagnostics has led to a tremendous increase in data and a vast number of variants of uncertain significance that require interpretation. Therefore, prediction of the ef
Externí odkaz:
https://doaj.org/article/2e5634ecfafe4cf48e3b007414e75fbd
Autor:
Friederike Flachsbart, Janina Dose, Liljana Gentschew, Claudia Geismann, Amke Caliebe, Carolin Knecht, Marianne Nygaard, Nandini Badarinarayan, Abdou ElSharawy, Sandra May, Anne Luzius, Guillermo G. Torres, Marlene Jentzsch, Michael Forster, Robert Häsler, Kathrin Pallauf, Wolfgang Lieb, Céline Derbois, Pilar Galan, Dmitriy Drichel, Alexander Arlt, Andreas Till, Ben Krause-Kyora, Gerald Rimbach, Hélène Blanché, Jean-François Deleuze, Lene Christiansen, Kaare Christensen, Michael Nothnagel, Philip Rosenstiel, Stefan Schreiber, Andre Franke, Susanne Sebens, Almut Nebel
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
FOXO3 is one of the few established longevity genes. Here, the authors fine-map the FOXO3-longevity association to two intronic SNPs and, using luciferase assays and EMSAs, show that these SNPs affect binding of transcription factors CTCF and SRF and
Externí odkaz:
https://doaj.org/article/f1d90b23cde74314abd23e1b467785a0
Autor:
María de la Puente, Jorge Ruiz-Ramírez, Adrián Ambroa-Conde, Catarina Xavier, Jacobo Pardo-Seco, Jose Álvarez-Dios, Ana Freire-Aradas, Ana Mosquera-Miguel, Theresa E. Gross, Elaine Y. Y. Cheung, Wojciech Branicki, Michael Nothnagel, Walther Parson, Peter M. Schneider, Manfred Kayser, Ángel Carracedo, Maria Victoria Lareu, Christopher Phillips, on behalf of the VISAGE Consortium
Publikováno v:
Genes, Vol 12, Iss 8, p 1284 (2021)
We detail the development of the ancestry informative single nucleotide polymorphisms (SNPs) panel forming part of the VISAGE Basic Tool (BT), which combines 41 appearance predictive SNPs and 112 ancestry predictive SNPs (three SNPs shared between se
Externí odkaz:
https://doaj.org/article/b990fa13de32479aa5901242e955879b
Publikováno v:
Diversity, Vol 13, Iss 7, p 325 (2021)
Knowledge about species’ distributions is central to diverse applications in ecology, biogeography, and conservation science. Hot-spring snakes of the genus Thermophis share a distribution restricted to geothermal sites at the Tibetan Plateau (T. b
Externí odkaz:
https://doaj.org/article/2cfe2c1cac6741299fe541f9a83b1381