Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Michael Nivala"'
Publikováno v:
Nivala, M; Song, Z; Weiss, JN; & Qu, Z. (2015). T-tubule disruption promotes calcium alternans in failing ventricular myocytes: Mechanistic insights from computational modeling. Journal of Molecular and Cellular Cardiology, 79, 32-41. doi: 10.1016/j.yjmcc.2014.10.018. UCLA: Retrieved from: http://www.escholarship.org/uc/item/6vg6q7xf
© 2014 Elsevier Ltd. In heart failure (HF), T-tubule (TT) disruption contributes to dyssynchronous calcium (Ca) release and impaired contraction, but its role in arrhythmogenesis remains unclear. In this study, we investigate the effects of TT disru
Publikováno v:
The Journal of Physiology. 591:5305-5320
Calcium (Ca(2+)) waves generating oscillatory Ca(2+) signals are widely observed in biological cells. Experimental studies have shown that under certain conditions, initiation of Ca(2+) waves is random in space and time, while under other conditions,
Autor:
Zhilin Qu, Michael Nivala
Publikováno v:
Multiscale Analysis and Nonlinear Dynamics: From Genes to the Brain
Autor:
Ralph Abraham, Michael Nivala
Publikováno v:
IIM Kozhikode Society & Management Review. 2:157-163
A brief introductory article on the role of chaotic synchronization in the context of complex economic systems. The basic framework developed by the late Richard Goodwin in his book, Chaotic Economic Dynamics, of 1990 has been extended to massively c
Publikováno v:
Scientific reports, vol 6, iss 1
Scientific Reports
Scientific Reports
Intracellular calcium (Ca2+) alternans is a dynamical phenomenon in ventricular myocytes, which is linked to the genesis of lethal arrhythmias. Iterated map models of intracellular Ca2+ cycling dynamics in ventricular myocytes under periodic pacing h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13e68633ed6f900bca4d1543c62b27f5
https://escholarship.org/uc/item/5sx3r41s
https://escholarship.org/uc/item/5sx3r41s
Autor:
Michael Nivala, Zhilin Qu
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 303:H341-H352
Intracellular calcium (Ca) alternans in cardiac myocytes have been shown in many experimental studies, and the mechanisms remain incompletely understood. We recently developed a “3R theory” that links Ca sparks to whole cell Ca alternans through
Publikováno v:
Biophysical Journal. 102(11):2433-2442
Calcium (Ca) is a ubiquitous second messenger that regulates many biological functions. The elementary events of local Ca signaling are Ca sparks, which occur randomly in time and space, and integrate to produce global signaling events such as intra-
Publikováno v:
Biophysical Journal. 101(9):2102-2111
It has been shown that transient single mitochondrial depolarizations, known as flickers, tend to occur randomly in space and time. On the other hand, many studies have shown that mitochondrial depolarization waves and whole-cell oscillations occur u
Publikováno v:
Circulation Research. 108:98-112
The goal of systems biology is to relate events at the molecular level to more integrated scales from organelle to cell, tissue, and living organism. Here, we review how normal and abnormal excitation–contraction coupling properties emerge from the
Autor:
Michael Nivala, Bernard Deconinck
Publikováno v:
Physica D: Nonlinear Phenomena. 239:1147-1158
The stability of periodic solutions of partial differential equations has been an area of increasing interest in the last decade. The KdV equation is known to have large families of periodic solutions that are parameterized by hyperelliptic Riemann s