Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Michael Niederweis"'
Autor:
Ravi K. Lokareddy, Chun-Feng David Hou, Francesca Forti, Stephano M. Iglesias, Fenglin Li, Mikhail Pavlenok, David S. Horner, Michael Niederweis, Federica Briani, Gino Cingolani
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract DEV is an obligatory lytic Pseudomonas phage of the N4-like genus, recently reclassified as Schitoviridae. The DEV genome encodes 91 ORFs, including a 3398 amino acid virion-associated RNA polymerase (vRNAP). Here, we describe the complete a
Externí odkaz:
https://doaj.org/article/f0520421212b4ab68758fafb4b4c926f
Autor:
Shamira J. Shallom, Hervé Tettelin, Prabha Chandrasekaran, In Kwon Park, Sonia Agrawal, Kriti Arora, Lisa Sadzewicz, Aaron M. Milstone, Moira L. Aitken, Barbara A. Brown-Elliott, Richard J. Wallace, Elizabeth P. Sampaio, Michael Niederweis, Kenneth N. Olivier, Steven M. Holland, Adrian M. Zelazny
Publikováno v:
Virulence, Vol 14, Iss 1 (2023)
ABSTRACTBackground Mycobacterium abscessus subspecies massiliense (M. massiliense) is increasingly recognized as an emerging bacterial pathogen, particularly in cystic fibrosis (CF) patients and CF centres’ respiratory outbreaks. We characterized g
Externí odkaz:
https://doaj.org/article/1d3e83e79bc44125bc0ecce45076b372
Autor:
Lei Zhang, James E. Kent, Meredith Whitaker, David C. Young, Dominik Herrmann, Alexander E. Aleshin, Ying-Hui Ko, Gino Cingolani, Jamil S. Saad, D. Branch Moody, Francesca M. Marassi, Sabine Ehrt, Michael Niederweis
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The pathogen Mycobacterium tuberculosis uses the siderophores called mycobactins and carboxymycobactins to acquire iron from the host. Here, Zhang et al. identify a protein that is important for siderophore secretion and for the pathogen’s growth i
Externí odkaz:
https://doaj.org/article/251ba6d7e8674c55b91f689c769c3dd9
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The tuberculosis necrotizing toxin (TNT) is the major cytotoxicity factor of M. tuberculosis (Mtb). Mtb possesses five type VII secretion systems (ESX). Pajuelo et al. show that the ESX-4 system is required for TNT secretion and that ESX-2 and ESX-4
Externí odkaz:
https://doaj.org/article/c9ec7194658a4792a80fd186b7ed107b
Autor:
Rebecca K. Donegan, Yibo Fu, Jacqueline Copeland, Stanzin Idga, Gabriel Brown, Owen F. Hale, Avishek Mitra, Hui Yang, Harry A. Dailey, Michael Niederweis, Paras Jain, Amit R. Reddi
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 5 (2022)
ABSTRACT Heme is both an essential cofactor and an abundant source of nutritional iron for the human pathogen Mycobacterium tuberculosis. While heme is required for M. tuberculosis survival and virulence, it is also potentially cytotoxic. Since M. tu
Externí odkaz:
https://doaj.org/article/7bf3e26261654a098f9c0eb2fdff1297
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Tuberculosis necrotizing toxin (TNT) is secreted by Mycobacterium tuberculosis to kill host cells. Here, Tak, Dokland and Niederweis show that proteins EsxE and EsxF form membrane-spanning hetero-oligomeric pores that are important for TNT secretion.
Externí odkaz:
https://doaj.org/article/1e3b681c61014243b9c8f3663749dc0e
Autor:
Yong Zi Tan, José Rodrigues, James E. Keener, Ruixiang Blake Zheng, Richard Brunton, Brian Kloss, Sabrina I. Giacometti, Ana L. Rosário, Lei Zhang, Michael Niederweis, Oliver B. Clarke, Todd L. Lowary, Michael T. Marty, Margarida Archer, Clinton S. Potter, Bridget Carragher, Filippo Mancia
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
The cryo-EM structure of Mycobacterium smegmatis arabinosyltransferase B EmbB involved in mycobacterial cell wall biosynthesis provides insights into the substrate binding and reaction mechanism. Mapping of the ethambutol resistance associated mutati
Externí odkaz:
https://doaj.org/article/eeb46691fab54cb4aea7d475e6b51125
Autor:
Kai S. Beckwith, Marianne S. Beckwith, Sindre Ullmann, Ragnhild S. Sætra, Haelin Kim, Anne Marstad, Signe E. Åsberg, Trine A. Strand, Markus Haug, Michael Niederweis, Harald A. Stenmark, Trude H. Flo
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Inflammasome activation is a response to bacterial infection but can cause damage and spread infection. Here, the authors use live single-cell imaging to show two mechanisms by which M. tuberculosis causes damage to human macrophage cell plasma membr
Externí odkaz:
https://doaj.org/article/9546bc66dd1e4c0bb737b9ca565a8f54
Autor:
Nicholas A. Swanson, Ravi K. Lokareddy, Fenglin Li, Chun-feng Hou, Mikhail Pavlenok, Michael Niederweis, Gino Cingolani
Publikováno v:
STAR Protocols, Vol 2, Iss 4, Pp 100960- (2021)
Summary: Bacteriophages of the Podoviridae family densely package their genomes into precursor capsids alongside internal virion proteins called ejection proteins. In phage T7 these proteins (gp14, gp15, and gp16) are ejected into the host envelope f
Externí odkaz:
https://doaj.org/article/01c100bce6b94e788ce7a8bc10be80d3
Autor:
Brady L Spencer, Uday Tak, Jéssica C Mendonça, Prescilla E Nagao, Michael Niederweis, Kelly S Doran
Publikováno v:
PLoS Pathogens, Vol 17, Iss 12, p e1010121 (2021)
Type VII secretion systems (T7SS) have been identified in Actinobacteria and Firmicutes and have been shown to secrete effector proteins with functions in virulence, host toxicity, and/or interbacterial killing in a few genera. Bioinformatic analysis
Externí odkaz:
https://doaj.org/article/cc0cd1fd68b04638a81936fd382375b9