Výsledky vyhledávání - "Michael Namaka"

Akademický článek

Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)

The metabolic regulator protein family, mTOR, regulate natural killer (NK) cell development and function, but the underlying mechanism is unclear. Here, the authors show that Raptor/mTORC1 and Rictor/mTORC2 form a feedback crosstalk network to varieg

Externí odkaz: https://doaj.org/article/aed5a9a2b75b4c99ac71c6c1c1c72f87

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Akademický článek

Post-Natal Inhibition of NF-κB Activation Prevents Renal Damage Caused by Prenatal LPS Exposure.

Autor: Wei Guo, Xiao Guan, Xiaodong Pan, Xiongshan Sun, Fangjie Wang, Yan Ji, Pei Huang, Yafei Deng, Qi Zhang, Qi Han, Ping Yi, Michael Namaka, Ya Liu, Youcai Deng, Xiaohui Li

Publikováno v: PLoS ONE, Vol 11, Iss 4, p e0153434 (2016)

Prenatal exposure to an inflammatory stimulus has been shown to cause renal damage in offspring. Our present study explored the role of intra-renal NF-κB activation in the development of progressive renal fibrosis in offspring that underwent prenata

Externí odkaz: https://doaj.org/article/f8e8796321e14246a584feae6225a6e9

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DNA hydroxymethylation changes in response to spinal cord damage in a multiple sclerosis mouse model

Autor: Michael Namaka, Tina Khorshid Ahmad, Kailing Pan, Man Luo, Xingshun Xu, Zhigang Miao, Yongxiang Wang, Yan Tang, Ting Zhou, Hang Zhou, Hao Sun

Publikováno v: Epigenomics. 11:323-335

Aim: Roles of DNA 5-hydroxymethylcytosine (5hmC) in myelin repair were investigated in an experimental autoimmune encephalomyelitis (EAE) mouse model via its regulation on BDNF. Methods: DNA 5hmC level and its limiting enzymes were detected in EAE mi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dd3f228df38ddc2b628ed8fc54adc6b
https://doi.org/10.2217/epi-2018-0162

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Crosstalks between mTORC1 and mTORC2 variagate cytokine signaling to control NK maturation and effector function

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications

The metabolic checkpoint kinase mechanistic/mammalian target of rapamycin (mTOR) regulates natural killer (NK) cell development and function, but the exact underlying mechanisms remain unclear. Here, we show, via conditional deletion of Raptor (mTORC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cecfd22805361c46b6a27f362fe6369f
http://link.springer.com/article/10.1038/s41467-018-07277-9

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Toll-like receptor-4/p38 MAPK signaling in the dorsal horn contributes to P2X4 receptor activation and BDNF over-secretion in cancer induced bone pain

Autor: Si-lan Liu, Ming Yao, Xiao-hong Jin, Michael Namaka, Lina Wang, Jianling Zuo, Jian-ling Gao, Xiaowen Meng

Publikováno v: Neuroscience Research. 125:37-45

Our previous research suggested that the P2X4 receptor (P2X4R) expression in microglia was involved in the activation of toll-like receptor-4 (TLR4) in the dorsal horn in the rat model of cancer induced bone pain (CIBP). In this study, we focused on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6252c83f5cedfc56bbedabf8b3c13d97
https://doi.org/10.1016/j.neures.2017.06.006

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Therapeutic impact of orally administered cannabinoid oil extracts in an experimental autoimmune encephalomyelitis animal model of multiple sclerosis

Autor: Tyson Le, Karen Ethans, Howard Intrater, Marianna Pozdirca, Samaa Alrushaid, Ting Zhou, Frank J. Burczynski, Jiming Kong, Michael Namaka, Tina Khorshid Ahmad

Publikováno v: Biochemical and biophysical research communications. 516(2)

There is a growing surge of investigative research involving the beneficial use of cannabinoids as novel interventional alternatives for multiple sclerosis (MS) and associated neuropathic pain (NPP). Using an experimental autoimmune encephalomyelitis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e15ade9e379347aa6fe5b48e3a45079d
https://pubmed.ncbi.nlm.nih.gov/31213295

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Increased Post-Translational Lysine Acetylation of Myelin Basic Protein Is Associated with Peak Neurological Disability in a Mouse Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis

Autor: Ryan Lillico, Kiana Gozda, Jiming Kong, Ting Zhou, Jessica Truong, Michael Namaka, Tina Khorshid Ahmad, Ted M. Lakowski, Nicholas Stesco

Publikováno v: Journal of proteome research. 17(1)

Citrullination of arginine residues is a post-translational modification (PTM) found on myelin basic protein (MBP), which neutralizes MBPs positive charge, and is implicated in myelin damage and multiple sclerosis (MS). Here we identify lysine acetyl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad6020df7e07b48d662b3ef5ae99d62c
https://pubmed.ncbi.nlm.nih.gov/29111742

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Experimental Autoimmune Encephalomyelitis (EAE)-Induced Elevated Expression of the E1 Isoform of Methyl CpG Binding Protein 2 (MeCP2E1): Implications in Multiple Sclerosis (MS)-Induced Neurological Disability and Associated Myelin Damage

Autor: Ted M. Lakowski, Claudia Cortes, Ryan Lillico, Ting Zhou, Kiana Gozda, Khaled Al-Taweel, Michael Namaka, Tina Khorshid Ahmad

Publikováno v: International Journal of Molecular Sciences; Volume 18; Issue 6; Pages: 1254
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 18, Iss 6, p 1254 (2017)

Multiple sclerosis (MS) is a chronic neurological disease characterized by the destruction of central nervous system (CNS) myelin. At present, there is no cure for MS due to the inability to repair damaged myelin. Although the neurotrophin brain deri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5565fff49405647dfe843afdbe0c5c

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Implications of white matter damage in amyotrophic lateral sclerosis (Review)

Autor: Jiming Kong, Michael Namaka, Tina Khorshid Ahmad, Jessica Truong, Ting Zhou, Kiana Gozda

Publikováno v: Molecular Medicine Reports

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, which involves the progressive degeneration of motor neurons. ALS has long been considered a disease of the grey matter; however, pathological alterations of the white matter (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6fca448039577b7e81276be54257215
https://pubmed.ncbi.nlm.nih.gov/28791401

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