Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Michael Nahmou"'
Autor:
Ziming Luo, Kun-Che Chang, Suqian Wu, Catalina Sun, Xin Xia, Michael Nahmou, Minjuan Bian, Rain R. Wen, Ying Zhu, Sahil Shah, Bogdan Tanasa, Marius Wernig, Jeffrey L. Goldberg
Publikováno v:
Stem cell reports. 17(12)
Retinal ganglion cell (RGC) replacement therapy could restore vision in glaucoma and other optic neuropathies. We developed a rapid protocol for directly induced RGC (iRGC) differentiation from human stem cells, leveraging overexpression of NGN2. Neu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90596c6ffc0bdd1e62d7a51358618feb
https://pubmed.ncbi.nlm.nih.gov/36368332
https://pubmed.ncbi.nlm.nih.gov/36368332
Autor:
Pei S Zhuang, Kun-Che Chang, Leonard Siew, Qizhao Wang, Liang Liu, Yang Sun, Clarisse M. Fligor, Yang Hu, Alexander Kreymerman, Jason S. Meyer, Haoliang Huang, Roopa Dalal, Jeffrey L. Goldberg, Michael Nahmou, Hannah C. Webber, Liang Li
Publikováno v:
J Neurosci
Optic neuropathies are a group of optic nerve (ON) diseases caused by various insults including glaucoma, inflammation, ischemia, trauma, and genetic deficits, which are characterized by retinal ganglion cell (RGC) death and ON degeneration. An incre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f69c9e6ee3e4ebe8842403ecbd52617e
https://doi.org/10.1523/jneurosci.0102-20.2020
https://doi.org/10.1523/jneurosci.0102-20.2020
Autor:
Michael Nahmou, Evan G. Cameron, Jeffrey L. Goldberg, Kenneth J. Muller, Xiong Zhang, Praseeda Venugopalan
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports
Scientific Reports
During development, newly-differentiated neurons undergo several morphological and physiological changes to become functional, mature neurons. Physiologic maturation of neuronal cells derived from isolated stem or progenitor cells may provide insight
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c11dab6ffbebbf51bdde4847862975b3
http://link.springer.com/article/10.1038/s41598-020-58120-5
http://link.springer.com/article/10.1038/s41598-020-58120-5
Autor:
Jeffrey L. Goldberg, Dillon J. Rak, Melissa Atkins, Xin Xia, Noelia J. Kunzevitzky, Roopa Dalal, Catalina B. Sun, C. Andres Benatti, Olga Kuzmenko, Michael Nahmou, Kun-Che Chang
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose Corneal endothelial dysfunction leads to corneal edema, pain, and vision loss. Adequate animal models are needed to study the safety and efficacy of novel cell therapies as an alternative to corneal transplantation. Methods Primary human corn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38359094299c4a9068a2e509547955cc
http://europepmc.org/articles/PMC6546151
http://europepmc.org/articles/PMC6546151
Publikováno v:
RSC advances. 11(57)
Magnetic nanoparticles (MNPs) are widely used in cell sorting, organelle selection, drug delivery, cell delivery, and cell tracking applications. However, organelle manipulation in living cells has been limited due to the endocytic uptake and sequest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e8c4f0181919590e031f821d1588432
https://pubmed.ncbi.nlm.nih.gov/35492766
https://pubmed.ncbi.nlm.nih.gov/35492766
Autor:
Graham Anderson, Pierre Bagnaninchi, Bernard Baumel, Alexander Birbrair, Ryan Bloomquist, Ana Bugallo-Casal, Christian Camargo, Francisco Campos, Kun-Che Chang, Umber Cheema, Alan Dardik, Jugal Kishore Das, Baljean Dhillon, M. Teresa Donato, G.L. Dunbar, Xixiang Gao, Jolanta Gorecka, Yongquan Gu, Chin Meng Khoo, Kwang-Soo Kim, Anil Kumar, Hwee Hui Lau, Ziming Luo, Michelle Marrero, Shigeru Miyagawa, Mahmood S. Mozaffari, Michael Nahmou, Manabu Ohyama, Víctor H. Parraguez, María Pelechá, Hao-Yun Peng, Oscar A. Peralta, Milena Pinto, María Pérez-Mato, Yijie Ren, J. Rossignol, Yoshiki Sawa, Jeffrey S. Schweitzer, Bin Song, Jianxun Song, B. Srinageshwar, Wei Xuan Tan, Nguan Soon Tan, Adrian Kee Keong Teo, Laia Tolosa, Cristian G. Torres, Liqing Wang, Yingfeng Wu, Xiaofang Xiong
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb6ae012cc1ce2adb5548a8a3e9b7b82
https://doi.org/10.1016/b978-0-12-822229-4.01002-0
https://doi.org/10.1016/b978-0-12-822229-4.01002-0
Publikováno v:
Recent Advances in iPSCs for Therapy, Volume 3 ISBN: 9780128222294
Glaucoma and optic neuropathy cause permanent blindness due to loss of retinal ganglion cells (RGCs) and their axons, which are both important components of visual circuits. RGC axons neither regrow nor are they replaced after injury and death, for w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1c31ae2c4a291a8f6c476b542d70df90
https://doi.org/10.1016/b978-0-12-822229-4.00010-3
https://doi.org/10.1016/b978-0-12-822229-4.00010-3
Autor:
Sahil H. Shah, Lucio M. Schiapparelli, Satoshi Yokota, Yuanhui Ma, Xin Xia, Sahana Shankar, Sarah Saturday, Michael Nahmou, Catalina Sun, John Yates, Hollis T. Cline, Jeffrey L. Goldberg
Publikováno v:
J Neurosci
Retinal ganglion cells (RGCs) die after optic nerve trauma or in degenerative disease. However, acute changes in protein expression that may regulate RGC response to injury are not fully understood, and detailed methods to quantify new protein synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd8b0ac5e6c555832a489916110d3006
https://pubmed.ncbi.nlm.nih.gov/35396330
https://pubmed.ncbi.nlm.nih.gov/35396330
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose The purpose of this study was to characterize whether induced pluripotent stem cells (iPSCs) affect survival of grafted retinal ganglion cells (RGCs) after transplantation. Methods For in vitro studies, human iPSCs were either directly cocult
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37ad1d4f30c661614cb6a377128fe6a9
http://europepmc.org/articles/PMC5863687
http://europepmc.org/articles/PMC5863687
Autor:
Patrick W. Keeley, Michael Nahmou, Gabriel Luna, Steven K. Fisher, Benjamin E. Reese, Amanda G. Kautzman
Publikováno v:
Glia. 66:623-636
Sox2 is a transcriptional regulator that is highly expressed in retinal astrocytes, yet its function in these cells has not previously been examined. To understand its role, we conditionally deleted Sox2 from the population of astrocytes and examined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e21c31d7aab10d242297080b7cbe9e
https://doi.org/10.1002/glia.23269
https://doi.org/10.1002/glia.23269