Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Michael N. Gwynn"'
Autor:
Graham Elgin Jones, Alan Joseph Hennessy, Steve Rittenhouse, Ilaria Giordano, Roger Edward Markwell, Steven Dabbs, Michael N. Gwynn, David T. Davies, Jennifer Hoover, Nathalie Cailleau, Barry S. Brown, Joel Michael Esken, Neil D. Pearson, Pamela Brown, Dongzhao Chen, Elisabeth A. Minthorn, Ben Bax, Gerald Brooks, Timothy J. Miles, Senthill K. Kusalakumari Sukmar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:2464-2469
During the course of our research on the lead optimisation of the NBTI (Novel Bacterial Type II Topoisomerase Inhibitors) class of antibacterials, we discovered a series of tricyclic compounds that showed good Gram-positive and Gram-negative potency.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f67eb26144e4e029d7a0d4e17988e6f
https://doi.org/10.1016/j.bmcl.2016.03.106
https://doi.org/10.1016/j.bmcl.2016.03.106
Autor:
Michael N. Gwynn, Jianzhong Huang, Martin Hibbs, Claus Spitzfaden, Jason Pizzollo, Haifeng Cui, Velupillai Srikannathasan, Robert Tanner, Karen A. Ingraham, Robert A. Stavenger, Pan F. Chan, Minghua Gu, Carol Shen, Paul Homes, Andrew J. Theobald, Andrew P. Fosberry, Anthony Shillings, Michael M. Hann, Benjamin D. Bax
Publikováno v:
Nature Communications
New antibacterials are needed to tackle antibiotic-resistant bacteria. Type IIA topoisomerases (topo2As), the targets of fluoroquinolones, regulate DNA topology by creating transient double-strand DNA breaks. Here we report the first co-crystal struc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9b4c3994d8361a48efe0cd59325b97
https://doi.org/10.1038/ncomms10048
https://doi.org/10.1038/ncomms10048
Autor:
Pamela Brown, Roger Edward Markwell, David L. Downie, Susanne Eyrisch, Neil D. Pearson, Dongzhao Chen, Christopher Barfoot, Stephen Rittenhouse, Graham Elgin Jones, Mark A. Seefeld, Elizabeth A. Minthorn, Jeffrey M. Axten, Steven Dabbs, Alan Joseph Hennessy, Michael N. Gwynn, Gerald Brooks, Jianzhong Huang, Ilaria Giordano, William H. Miller, David T. Davies, Timothy Francis Gallagher, Timothy J. Miles, Jennifer Hoover
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7489-7495
We have identified a series of amino-piperidine antibacterials with a good broad spectrum potency. We report the investigation of various subunits in this series and advanced studies on compound 8. Compound 8 possesses good pharmacokinetics, broad sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c89d8d5098d1fe72b99b9bbcc372d3c
https://doi.org/10.1016/j.bmcl.2011.09.117
https://doi.org/10.1016/j.bmcl.2011.09.117
Autor:
Stephen Rittenhouse, Neil D. Pearson, Christopher Barfoot, Graham Elgin Jones, Timothy J. Miles, David L. Downie, Dongzhao Chen, Steven Dabbs, Jennifer Hoover, Roger Edward Markwell, Alan Joseph Hennessy, Jianzhong Huang, Michael N. Gwynn, Ilaria Giordano, Gerald Brooks, Hong Xiang, David T. Davies, Susanne Eyrisch, Pamela Brown
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:7483-7488
As part of our wider efforts to exploit novel mode of action antibacterials, we have discovered a series of cyclohexyl-amide compounds that has good Gram positive and Gram negative potency. The mechanism of action is via inhibition of bacterial topoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3810e692448006878f359f5ce7432ed6
https://doi.org/10.1016/j.bmcl.2011.09.114
https://doi.org/10.1016/j.bmcl.2011.09.114
Publikováno v:
Annals of the New York Academy of Sciences. 1213:5-19
The discovery of novel antibiotic classes has not kept pace with the growing threat of bacterial resistance. Antibiotic candidates that act at new targets or via distinct mechanisms have the greatest potential to overcome resistance; however, novel a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ecdd594514e986f6bb89473eff25705
https://doi.org/10.1111/j.1749-6632.2010.05828.x
https://doi.org/10.1111/j.1749-6632.2010.05828.x
Autor:
Claus Spitzfaden, Paul Homes, Andrew P. Fosberry, Jianzhong Huang, Martin Hibbs, Michael N. Gwynn, Anthony Shillings, Alexandre Wohlkonig, Andrew J. Theobald, Pan F. Chan, Velupillai Srikannathasan, Onkar M. P. Singh, Benjamin D. Bax
Fluoroquinolone drugs such as moxifloxacin kill bacteria by stabilizing the normally transient double-stranded DNA breaks created by bacterial type IIA topoisomerases. Previous crystal structures of Staphylococcus aureus DNA gyrase with asymmetric DN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab10eeb8df12cca74374d1610c9aeae7
https://hdl.handle.net/20.500.14017/22db32c0-99c6-4908-a958-7283af6f9d72
https://hdl.handle.net/20.500.14017/22db32c0-99c6-4908-a958-7283af6f9d72
Autor:
Linda A. Miller, Michael J. Italia, Michael N. Gwynn, Julie A. Becker, Heather Amrine-Madsen, Michael J. Stanhope, Tom Mathie, J. A. Poupard, Stacey L. Walsh, Karen A. Ingraham, James R. Brown
Publikováno v:
Antimicrobial Agents and Chemotherapy. 49:4315-4326
Fluoroquinolones are an important class of antibiotics for the treatment of infections arising from the gram-positive respiratory pathogen Streptococcus pneumoniae . Although there is evidence supporting interspecific lateral DNA transfer of fluoroqu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a0316135d216774bb7bdffdd65e1e65
https://doi.org/10.1128/aac.49.10.4315-4326.2005
https://doi.org/10.1128/aac.49.10.4315-4326.2005
Autor:
Michael N. Gwynn, Martin Rosenberg, Nino Campobasso, Howard Kallender, Mehul Patel, Imogen E. Wilding
Publikováno v:
Journal of Biological Chemistry. 279:44883-44888
3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase, a member of the family of acyl-condensing enzymes, catalyzes the first committed step in the mevalonate pathway and is a potential target for novel antibiotics and cholesterol-lowering agents.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fa4b1c228c4d3b0b47baaa6fed1b801
https://doi.org/10.1074/jbc.m407882200
https://doi.org/10.1074/jbc.m407882200
Publikováno v:
Journal of Biological Chemistry. 278:8861-8868
Type II topoisomerases bind to DNA at the catalytic domain across the DNA gate. DNA gyrases also bind to DNA at the non-homologous C-terminal domain of the GyrA subunit, which causes the wrapping of DNA about itself. This unique mode of DNA binding a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b06a9dcf300b6c51bf703c922ed2029
https://doi.org/10.1074/jbc.m209207200
https://doi.org/10.1074/jbc.m209207200
Autor:
Cynthia V. Stauffacher, John W. Burgner, Autumn Sutherlin, Kevin R. Lehnbeuter, E. Imogen Wilding, Victor W. Rodwell, Damien McDevitt, Marie J. Mazzulla, Pamela Lane, Michael N. Gwynn, Matija Hedl
Publikováno v:
Bindley Publications
Many bacteria employ the nonmevalonate pathway for synthesis of isopentenyl diphosphate, the monomer unit for isoprenoid biosynthesis. However, gram-positive cocci exclusively use the mevalonate pathway, which is essential for their growth (E. I. Wil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e35170e53caf399a86f3f6bf2124d3d0
https://doi.org/10.1128/jb.184.8.2116-2122.2002
https://doi.org/10.1128/jb.184.8.2116-2122.2002