Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Michael N. C. Fletcher"'
Autor:
Emma Phillips, Jörg Balss, Frederic Bethke, Stefan Pusch, Stefan Christen, Thomas Hielscher, Martina Schnölzer, Michael N. C. Fletcher, Antje Habel, Claudia Tessmer, Lisa-Marie Brenner, Mona Göttmann, David Capper, Christel Herold-Mende, Andreas von Deimling, Sarah-Maria Fendt, Violaine Goidts
Publikováno v:
Oncogenesis, Vol 11, Iss 1, Pp 1-12 (2022)
Abstract Glioblastoma is a highly aggressive brain tumor for which there is no cure. The metabolic enzyme 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4 (PFKFB4) is essential for glioblastoma stem-like cell (GSC) survival but its mode of actio
Externí odkaz:
https://doaj.org/article/a08fd162f6184b9cb768a5cefba94123
Autor:
Emma Phillips, Jörg Balss, Frederic Bethke, Stefan Pusch, Stefan Christen, Thomas Hielscher, Martina Schnölzer, Michael N. C. Fletcher, Antje Habel, Claudia Tessmer, Lisa-Marie Brenner, Mona Göttmann, David Capper, Christel Herold-Mende, Andreas von Deimling, Sarah-Maria Fendt, Violaine Goidts
Glioblastoma is a highly aggressive brain tumor for which there is no cure. The metabolic enzyme 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4 (PFKFB4) is essential for glioblastoma stem-like cell (GSC) survival but its mode of action is uncl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7754ce7b3ff05040653481e4ebc00749
https://lirias.kuleuven.be/handle/20.500.12942/706899
https://lirias.kuleuven.be/handle/20.500.12942/706899
Autor:
Bernhard Radlwimmer, Ann Christin Gaupel, Yonghe Wu, Magdalena Schlotter, Wei Wang, Hai-Kun Liu, Qi Wang, Ka Hou Man, Michael N. C. Fletcher, Andrey Korshunov, Peter Angel, Zuguang Gu, Michael Weller, Martje Barbus, Jörg Felsberg, Barbara Costa, Anna Marta Maria Bertoni, Carl Herrmann, Peter Lichter, Tobias Weiss, Roland Eils, Guido Reifenberger, Jasmin Mangei
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
Nature Communications
Nature Communications
Glioblastoma frequently exhibits therapy-associated subtype transitions to mesenchymal phenotypes with adverse prognosis. Here, we perform multi-omic profiling of 60 glioblastoma primary tumours and use orthogonal analysis of chromatin and RNA-derive
Autor:
Michael N. C. Fletcher, Shaman Rahman, Tolga Lokumcu, Bryan W. Day, Laura Puccio, Tobias Kessler, Ulrich Baumgartner, Felix Sahm, Wolfgang Wick, Thomas Hielscher, Silja Schlue, Obada T Alhalabi, Ling Hai, Lea Hansen-Palmus, Elena Wittmann, Emma Phillips, Mona Göttmann, Christel Herold-Mende, Ichiro Nakano, Violaine Goidts
Publikováno v:
Neuro Oncol
Background Glioblastoma is the most common primary malignancy of the central nervous system with a dismal prognosis. Genomic signatures classify isocitrate dehydrogenase 1 (IDH)-wildtype glioblastoma into three subtypes: proneural, mesenchymal, and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e81b56ecce2a59d2254392ed6da7ae9
https://europepmc.org/articles/PMC8730774/
https://europepmc.org/articles/PMC8730774/
Autor:
Lucy F. Stead, Daniel J. Brat, Michael D. Jenkinson, Michael Schuster, Michael Weller, Hiromichi Suzuki, Raul Rabadan, Kristin Alfaro, Do-Hyun Nam, D. Ryan Ormond, Gaetano Finocchiaro, Anzhela D. Moskalik, Hoon Kim, Jason K. Sa, Mustafa Khasraw, Chew Yee Ngan, Andrew E. Sloan, Peter Gould, Mark R. Gilbert, Ganesh Rao, Michael N. C. Fletcher, Brian L. Shaw, Houtan Noushmehr, Ketan R. Bulsara, Naema Nayyar, Elizabeth B. Claus, Colin Watts, Samirkumar B. Amin, Pim J. French, Rameen Beroukhim, Azzam Ismail, Erwin G. Van Meir, Matthew R. Grimmer, Andrew R Brodbelt, Joseph F. Costello, W. K. Alfred Yung, Susan C Short, Meihong Li, Guido Reifenberger, Adelheid Woehrer, Aruna Chakrabarty, Hui K Gan, Keith L. Ligon, Roel G.W. Verhaak, Chul-Kee Park, Simone P. Niclou, Georgette Tanner, Frederick S. Varn, Arnab Chakravarti, Javad Noorbakhsh, Floris P. Barthel, Jason T. Huse, Christoph Bock, Annette M. Molinaro, Georg Widhalm, Alexander F. Bruns, Olajide Abiola, Tathiane M. Malta, Pieter Wesseling, Tali Mazor, Donát Alpár, Peter Lichter, Jill S. Barnholtz-Sloan, Priscilla K. Brastianos, Antonio Iavarone, Laila M. Poisson, Jennifer Connelly, Bernhard Radlwimmer, Gelareh Zadeh, David M. Ashley, Ho Keung Ng, Ghazaleh Tabatabai, Peter A. E. Sillevis Smitt, Mathilde C.M. Kouwenhoven, Elizabeth J. Cochran, Jeffrey H. Chuang, Pratiti Bandopadhayay, Kevin C. Johnson, Marion Smits, Allison Lowman, John de Groot, Kevin J. Anderson, Johanna M. Niers, Bart A. Westerman, Peter S. LaViolette, Emre Kocakavuk, Kenneth Aldape, Kerrie L. McDonald
Publikováno v:
Nature, vol 576, iss 7785
Nature, 576(7785), 112-120. Nature Publishing Group
Nature
Barthel, F P, Johnson, K C, Varn, F S, Moskalik, A D, Tanner, G, Kocakavuk, E, Anderson, K J, Abiola, O, Aldape, K, Alfaro, K D, Alpar, D, Amin, S B, Ashley, D M, Bandopadhayay, P, Barnholtz-Sloan, J S, Beroukhim, R, Bock, C, Brastianos, P K, Brat, D J, Brodbelt, A R, Bruns, A F, Bulsara, K R, Chakrabarty, A, Chakravarti, A, Chuang, J H, Claus, E B, Cochran, E J, Connelly, J, Costello, J F, Finocchiaro, G, Fletcher, M N, French, P J, Gan, H K, Gilbert, M R, Gould, P V, Grimmer, M R, Iavarone, A, Ismail, A, Jenkinson, M D, Khasraw, M, Kim, H, Kouwenhoven, M C M, LaViolette, P S, Li, M, Lichter, P, Ligon, K L, Lowman, A K, Malta, T M, Mazor, T, McDonald, K L, Molinaro, A M, Nam, D H, Nayyar, N, Ng, H K, Ngan, C Y, Niclou, S P, Niers, J M, Noushmehr, H, Noorbakhsh, J, Ormond, D R, Park, C K, Poisson, L M, Rabadan, R, Radlwimmer, B, Rao, G, Reifenberger, G, Sa, J K, Schuster, M, Shaw, B L, Short, S C, Smitt, P A S, Sloan, A E, Smits, M, Suzuki, H, Tabatabai, G, Van Meir, E G, Watts, C, Weller, M, Wesseling, P, Westerman, B A, Widhalm, G, Woehrer, A, Yung, W K A, Zadeh, G, Huse, J T, De Groot, J F, Stead, L F, Verhaak, R G W & The GLASS Consortium 2019, ' Longitudinal molecular trajectories of diffuse glioma in adults ', Nature, vol. 576, no. 7785, pp. 112-120 . https://doi.org/10.1038/s41586-019-1775-1, https://doi.org/10.1038/s41586-019-1775-1
Nature, 576(7785), 112-120. Nature Publishing Group
Nature
Barthel, F P, Johnson, K C, Varn, F S, Moskalik, A D, Tanner, G, Kocakavuk, E, Anderson, K J, Abiola, O, Aldape, K, Alfaro, K D, Alpar, D, Amin, S B, Ashley, D M, Bandopadhayay, P, Barnholtz-Sloan, J S, Beroukhim, R, Bock, C, Brastianos, P K, Brat, D J, Brodbelt, A R, Bruns, A F, Bulsara, K R, Chakrabarty, A, Chakravarti, A, Chuang, J H, Claus, E B, Cochran, E J, Connelly, J, Costello, J F, Finocchiaro, G, Fletcher, M N, French, P J, Gan, H K, Gilbert, M R, Gould, P V, Grimmer, M R, Iavarone, A, Ismail, A, Jenkinson, M D, Khasraw, M, Kim, H, Kouwenhoven, M C M, LaViolette, P S, Li, M, Lichter, P, Ligon, K L, Lowman, A K, Malta, T M, Mazor, T, McDonald, K L, Molinaro, A M, Nam, D H, Nayyar, N, Ng, H K, Ngan, C Y, Niclou, S P, Niers, J M, Noushmehr, H, Noorbakhsh, J, Ormond, D R, Park, C K, Poisson, L M, Rabadan, R, Radlwimmer, B, Rao, G, Reifenberger, G, Sa, J K, Schuster, M, Shaw, B L, Short, S C, Smitt, P A S, Sloan, A E, Smits, M, Suzuki, H, Tabatabai, G, Van Meir, E G, Watts, C, Weller, M, Wesseling, P, Westerman, B A, Widhalm, G, Woehrer, A, Yung, W K A, Zadeh, G, Huse, J T, De Groot, J F, Stead, L F, Verhaak, R G W & The GLASS Consortium 2019, ' Longitudinal molecular trajectories of diffuse glioma in adults ', Nature, vol. 576, no. 7785, pp. 112-120 . https://doi.org/10.1038/s41586-019-1775-1, https://doi.org/10.1038/s41586-019-1775-1
The evolutionary processes that drive universal therapeutic resistance in adult patients with diffuse glioma remain unclear1,2. Here we analysed temporally separated DNA-sequencing data and matched clinical annotation from 222 adult patients with gli
Autor:
Ernest Fraenkel, Wolfgang Wick, Thomas Hielscher, Felix Sahm, O Alhalabi, Goidts, Emma Phillips, S Rahman, Mona Göttmann, Ulrich Baumgartner, Laura Puccio, Ichiro Nakano, Tobias Kessler, Murat Iskar, S Schlue, Ling Hai, Christel Herold-Mende, E Wittmann, M Gold, L Hansen-Palmus, Michael N. C. Fletcher, Bryan W. Day
Publikováno v:
Neuro-Oncology. 23:ii19-ii19
BACKGROUND Glioblastoma is the most common primary malignancy of the central nervous system with a dismal prognosis, even with surgical and chemoradiotherapy. Expression profiling studies classify IDH-wildtype Glioblastoma into three subtypes: Proneu
Autor:
Anand Thippeswamy, Lisa Becker, Mirjam Becker, Frederik Marmé, Roberto Würth, Michael N. C. Fletcher, Lars Velten, Sarah Jauch, Andreas Trumpp, Martin R. Sprick, Peter Lichter, Andreas Schneeweiss, Laura Michel, Simon Haas, Marc Zapatka, Lars M. Steinmetz
Publikováno v:
Cancer Research. 80:PD2-01
Although the survival of patients diagnosed with breast cancer has greatly improved over the last decades, the metastatic stage of the disease still remains incurable. Blood circulating tumor cells (CTCs) are assumed to be the source for metastatic o
Autor:
Stefano Lazzarano, Marek Kučka, Claude Libert, Michael N. C. Fletcher, Tino Hochepied, Ronald Naumann, Paloma Medina, Rebecka Wombacher, Marc Van Montagu, Yingguang Frank Chan, Joao P. L. Castro, Joost Gribnau
Publikováno v:
Proceedings of the National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of Ame, 115(14), 3680-3685. National Academy of Sciences
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of Ame, 115(14), 3680-3685. National Academy of Sciences
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Significance How species differ from each other is a key question in biology. However, genetic mapping between species often fails because of sterile hybrid crosses. Here, we have developed a technique called in vitro recombination to circumvent bree
Autor:
Rebecka Wombacher, Claude Libert, Marek Kučka, Joost Gribnau, Yingguang Frank Chan, Tino Hochepied, Paloma Medina, Ronald Naumann, Michael N. C. Fletcher, Stefano Lazzarano, Joao P. L. Castro
Discovering the genetic changes underlying species differences is a central goal in evolutionary genetics. However, hybrid crosses between species in mammals often suffer from hybrid sterility, greatly complicating genetic dissection of trait variati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7474eb5d9cde1e32f4fa3190f14e19e5
https://doi.org/10.1101/148486
https://doi.org/10.1101/148486
Autor:
Verena Körber, Damian Stichel, Katrin Lamszus, Andreas von Deimling, Christel Herold-Mende, David T.W. Jones, Pankaj Barah, Michael Sabel, Michael N. C. Fletcher, Thomas Höfer, Zuguang Gu, Kerstin Kaulich, Jörg Felsberg, Bettina Hentschel, Guido Reifenberger, Angela Zacher, Jörg C. Tonn, Gabriele Schackert, Daniel Hübschmann, Michael Weller, Jing Yang, Matthias Schlesner, Peter Lichter, Yonghe Wu, Bernhard Radlwimmer
Publikováno v:
Cancer Cell. 35:692-704.e12
We studied how intratumoral genetic heterogeneity shapes tumor growth and therapy response for isocitrate dehydrogenase (IDH)-wild-type glioblastoma, a rapidly regrowing tumor. We inferred the evolutionary trajectories of matched pairs of primary and