Synthetic 5-amino-6-D-ribitylaminouracil paired with inflammatory stimuli facilitates MAIT cell expansion in vivo

Autor: Adam G. Nelson, Huimeng Wang, Phoebe M. Dewar, Eleanor M. Eddy, Songyi Li, Xin Yi Lim, Timothy Patton, Yuchen Zhou, Troi J. Pediongco, Lucy J. Meehan, Bronwyn S. Meehan, Jeffrey Y. W. Mak, David P. Fairlie, Andrew W. Stent, Lars Kjer-Nielsen, James McCluskey, Sidonia B. G. Eckle, Alexandra J. Corbett, Michael N. T. Souter, Zhenjun Chen

Publikováno v: Frontiers in Immunology, Vol 14 (2023)

IntroductionMucosal-associated invariant T (MAIT) cells are a population of innate-like T cells, which mediate host immunity to microbial infection by recognizing metabolite antigens derived from microbial riboflavin synthesis presented by the MHC-I-

Externí odkaz: https://doaj.org/article/ac4779a9843b421f9ed2624be5af4d23

Human mucosal Vα7.2+CD161hi T cell distribution at physiologic state and in Helicobacter pylori infection

Autor: Norasate Boonpattanaporn, Thidarat Kongkaew, Panjana Sengprasert, Michael N T Souter, Narisorn Lakananurak, Rungsun Rerknimitr, Alexandra J Corbett, Rangsima Reantragoon

Publikováno v: Journal of Leukocyte Biology. 112:717-732

Mucosal-associated invariant T (MAIT) cells are innate-like, unconventional T cells that are present in peripheral blood and mucosal surfaces. A clear understanding of how MAIT cells in the mucosae function and their role in host immunity is still la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aa5d293c43d88a634f58f76da00102e4
https://doi.org/10.1002/jlb.4a0421-223rr

Hypersensitivities following allergen antigen recognition by unconventional T cells

Autor: Liyen Loh, Michael N. T. Souter, Zhenjun Chen, Sidonia B G Eckle, James McCluskey, Daniel G. Pellicci, Marcela de Lima Moreira

Publikováno v: Allergy. 75:2477-2490

Conventional T cells recognise protein-derived antigens in the context of major histocompatibility complex (MHC) class Ia and class II molecules and provide anti-microbial and anti-tumour immunity. Conventional T cells have also been implicated in ty

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82dbaa95187619b49c6dac0c61a437a0
https://doi.org/10.1111/all.14279

CD1b Tetramers Identify T Cells that Recognize Natural and Synthetic Diacylated Sulfoglycolipids from Mycobacterium tuberculosis

Autor: Momin Khan, Varinder K. Aggarwal, Ryan O. Emerson, Zuzanna Z. Moleda, Adriaan J. Minnaard, Martine Gilleron, D. Branch Moody, Charlotte A. James, Peter Reinink, Josephine F. Reijneveld, Dale I. Godfrey, Thomas J. Scriba, Michael N. T. Souter, Eleonora Diamanti, Krystle K. Q. Yu, Chetan Seshadri, Ildiko Van Rhijn, Stefanie Lenz, Daniel G. Pellicci, Vijayendar R. Yedulla, Jacques Prandi

Publikováno v: Cell Chemical Biology, 25(4), 392-402.e14. CELL PRESS
Cell Chemical Biology
Cell Chemical Biology, Cell Press, 2018, 25 (4), pp.392-402.e14. ⟨10.1016/j.chembiol.2018.01.006⟩
James, C A, Yu, K K Q, Gilleron, M, Prandi, J, Yedulla, V R, Moleda, Z Z, Diamanti, E, Khan, M, Aggarwal, V K, Reijneveld, J F, Reinink, P, Lenz, S, Emerson, R O, Scriba, T J, Souter, M N T, Godfrey, D I, Pellicci, D G, Moody, D B, Minnaard, A J, Seshadri, C & Van Rhijn, I 2018, ' CD1b tetramers identify T cells that recognize natural and synthetic diacylated sulfoglycolipids from mycobacterium tuberculosis ', Cell Chemical Biology, vol. 25, no. 4, pp. 392-402.e14 . https://doi.org/10.1016/j.chembiol.2018.01.006

Mycobacterial cell wall lipids bind the conserved CD1 family of antigen-presenting molecules and activate T cells via their T cell receptors (TCRs). Sulfoglycolipids (SGLs) are uniquely synthesized by Mycobacterium tuberculosis, but tools to study SG

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebd030b1c8830816e59dd5ba5035d093
https://research.rug.nl/en/publications/8014231c-9253-42d1-8bfb-4958487144b4

Characterization of Human Mucosal-associated Invariant T (MAIT) Cells

Autor: Shihan Li, Lars Kjer-Nielsen, Jamie Rossjohn, James McCluskey, Sidonia B G Eckle, Michael N. T. Souter, Katherine Kedzierska, Alexandra J. Corbett, Liyen Loh, Dale I. Godfrey, Nicholas A Gherardin, Zhenjun Chen, Bronwyn S. Meehan, David P. Fairlie, Daniel G. Pellicci

Publikováno v: Current protocols in immunologyLiterature Cited. 127(1)

Mucosal-associated invariant T (MAIT) cells are a subset of unconventional T cells restricted by the major histocompatibility complex (MHC) class I-like molecule MHC-related protein 1 (MR1). MAIT cells are found throughout the body, especially in hum

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a726bcb515f657614593fdef69c3678
https://pubmed.ncbi.nlm.nih.gov/31763790