Short-course IL-15 given as a continuous infusion led to a massive expansion of effective NK cells: implications for combination therapy with antitumor antibodies

Autor: Thomas A Waldmann, Kevin C Conlon, Sigrid P Dubois, Milos D Miljkovic, Thomas A Fleisher, Stefania Pittaluga, Jennifer Hsu-Albert, Bonita R Bryant, Michael N Petrus, Liyanage P Perera, Jürgen R Müller, Joanna H Shih

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 4 (2021)

Background Full application of cytokines as oncoimmunotherapeutics requires identification of optimal regimens. Our initial effort with intravenous bolus recombinant human interleukin-15 (rhIL-15) was limited by postinfusional reactions. Subcutaneous

Externí odkaz: https://doaj.org/article/8fdac10694eb4bbaaa43034d35e526dc

A novel model of alternative NF-κB pathway activation in anaplastic large cell lymphoma

Autor: Marshall E. Kadin, Yangyang Li, Hong-Bo Wang, Yijun Liu, Yibin Yang, Masao Nakagawa, Craig J. Thomas, Mu Sheng Zeng, Michael N. Petrus, Thomas A. Waldmann, Wenming Xiao, Jing Ping Zhang, Zhihui Song, Wei Wei

Publikováno v: Leukemia

Aberrant activation of NF-κB is the most striking oncogenic mechanism in B-cell lymphoma; however, its role in anaplastic large cell lymphomas (ALCL) has not been fully established and its activation mechanism(s) remain unclear. Using ALCL cell line

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::346431027790d6b632e3a580c8e17a67
https://doi.org/10.1038/s41375-020-01088-y

Germinal epimutation of Fragile Histidine Triad (FHIT) gene is associated with progression to acute and chronic adult T-cell leukemia diseases

Autor: Olivier Hermine, Vahid Asnafi, Izabela Bialuk, Marcia Bellon, Lee Ratner, Ambroise Marçais, Michael N. Petrus, Thomas A. Waldmann, Genoveffa Franchini, Toshiki Watanabe, Antoine Gessain, Masao Matsuoka, Christophe Nicot, Achiléa L. Bittencourt, Lourdes Farre, Veronica Galli, Xue Tao Bai

Publikováno v: Dipòsit Digital de la UB
Universidad de Barcelona
Molecular Cancer
Molecular Cancer, 2021, 20 (1), pp.86. ⟨10.1186/s12943-021-01370-2⟩
Molecular Cancer, Vol 20, Iss 1, Pp 1-15 (2021)

Background Human T cell Leukemia virus type 1 (HTLV-I) is etiologically linked to adult T cell leukemia/lymphoma (ATL) and an inflammatory neurodegenerative disease called HTLV-I-associated myelopathy or tropical spastic paraparesis (HAM/TSP). The ex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6510393e031c514bb0b9c0e9b58acbdb
http://hdl.handle.net/2445/178671

Enhanced efficacy of JAK1 inhibitor with mTORC1/C2 targeting in smoldering/chronic adult T cell leukemia

Autor: Richard N. Bamford, Meili Zhang, Yuquan Lin, Craig J. Thomas, Milos D. Miljkovic, Anusara Daenthanasanmak, Kevin C. Conlon, Bonita R. Bryant, Michael N. Petrus, Thomas A. Waldmann

Publikováno v: Translational Oncology
Translational Oncology, Vol 14, Iss 1, Pp 100913-(2021)

Highlights • IL-2Rα is expressed in the leukemic cells of smoldering/chronic ATL patients, leading to activation of the JAK/STAT pathway. • JAK1 inhibition with Upadacitinib inhibited cell proliferation and phosphorylation of STAT5 in cytokine-d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67d47f60005f01f6c4e7efa57cc0d2f0
http://europepmc.org/articles/PMC7585144

IL-2 receptors preassemble and signal in the ER/Golgi causing resistance to antiproliferative anti–IL-2Rα therapies

Autor: Zoltán Balajthy, Andrea Bodnár, Michael N. Petrus, Thomas A. Waldmann, Katalin Tóth, Meili Zhang, Ádám Kenesei, Gabriele Müller, György Vámosi, Károly Jambrovics, Julianna Volkó, Gábor Mocsár, Péter Várnai

Interleukin-2 (IL-2) and IL-15 play pivotal roles in T cell activation, apoptosis, and survival, and are implicated in leukemias and autoimmune diseases. Their heterotrimeric receptors share their β- and γ(c)-chains, but have distinct α-chains. An

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9883a3025ac2243c3ef40304ea484926
https://europepmc.org/articles/PMC6800387/