Výsledky vyhledávání - "Michael N G, James"

Akademický článek

Phosphorylation status of 72 kDa MMP-2 determines its structure and activity in response to peroxynitrite.

Autor: Anna Laura Jacob-Ferreira, Marcia Yuri Kondo, Pravas Kumar Baral, Michael N G James, Andrew Holt, Xiaohu Fan, Richard Schulz

Publikováno v: PLoS ONE, Vol 8, Iss 8, p e71794 (2013)

Matrix metalloproteinase-2 (MMP-2) is a key intra- and extra-cellular protease which contributes to several oxidative stress related pathologies. A molecular understanding of 72 kDa MMP-2 activity, directly mediated by S-glutathiolation of its cystei

Externí odkaz: https://doaj.org/article/1892197faec04d0cb36b90bea4312cb3

Zobrazit plný text záznamu

Akademický článek

The POM monoclonals: a comprehensive set of antibodies to non-overlapping prion protein epitopes.

Autor: Magdalini Polymenidou, Rita Moos, Mike Scott, Christina Sigurdson, Yong-Zhong Shi, Bill Yajima, Iva Hafner-Bratkovic, Roman Jerala, Simone Hornemann, Kurt Wuthrich, Anne Bellon, Martin Vey, Graciela Garen, Michael N G James, Nat Kav, Adriano Aguzzi

Publikováno v: PLoS ONE, Vol 3, Iss 12, p e3872 (2008)

PrP(Sc), a misfolded and aggregated form of the cellular prion protein PrP(C), is the only defined constituent of the transmissible agent causing prion diseases. Expression of PrP(C) in the host organism is necessary for prion replication and for pri

Externí odkaz: https://doaj.org/article/729d5a629adc4e109df2f2dba9164797

Zobrazit plný text záznamu

Thermodynamic Criterion for the Conformation of P1 Residues of Substrates and of Inhibitors in Complexes with Serine Proteinases

Autor: Katherine S. Bateman, Jinhui Ding, Philip J. Ganz, Charles W. Saunders, Michael Laskowski, Stephen Anderson, John L. Markley, M. A. Qasim, Stephen M. Lu, Michael N. G. James, Jikui Song

Publikováno v: Biochemistry. 38:7142-7150

Eglin c, turkey ovomucoid third domain, and bovine pancreatic trypsin inhibitor (Kunitz) are all standard mechanism, canonical protein inhibitors of serine proteinases. Each of the three belongs to a different inhibitor family. Therefore, all three h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::473a9ff8db7cf813f146f857a2a3c767
https://doi.org/10.1021/bi990265u

Zobrazit plný text záznamu

Interscaffolding Additivity. Association of P1 Variants of Eglin c and of Turkey Ovomucoid Third Domain with Serine Proteinases

Autor: Charles W. Saunders, Michael N. G. James, Katherine S. Bateman, Michael Laskowski, Philip J. Ganz, M. A. Qasim

Publikováno v: Biochemistry. 36:1598-1607

Standard mechanism protein inhibitors of serine proteinases share a common mechanism of interaction with their cognate enzymes. The P1 residue of the inhibitor interacts with the enzyme in a substrate-like manner. Its side chain becomes imbedded in t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9c1cbd4d6f3ad7d210b271659ff4e79
https://doi.org/10.1021/bi9620870

Zobrazit plný text záznamu

Non-nucleoside analogue inhibitors bind to an allosteric site on HCV NS5B polymerase. Crystal structures and mechanism of inhibition

Autor: Meitian, Wang, Kenneth K-S, Ng, Maia M, Cherney, Laval, Chan, Constantin G, Yannopoulos, Jean, Bedard, Nicolas, Morin, Nghe, Nguyen-Ba, Moulay H, Alaoui-Ismaili, Richard C, Bethell, Michael N G, James

Publikováno v: The Journal of biological chemistry. 278(11)

X-ray crystal structures of two non-nucleoside analogue inhibitors bound to hepatitis C virus NS5B RNA-dependent RNA polymerase have been determined to 2.0 and 2.9 A resolution. These noncompetitive inhibitors bind to the same site on the protein, ap

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6aa79dc34f527ab3e5837f7838640e08
https://pubmed.ncbi.nlm.nih.gov/12509436

Zobrazit plný text záznamu

Structure of arterivirus nsp4. The smallest chymotrypsin-like proteinase with an alpha/beta C-terminal extension and alternate conformations of the oxyanion hole

Autor: Isabelle H, Barrette-Ng, Kenneth K-S, Ng, Brian L, Mark, Danny, Van Aken, Maia M, Cherney, Craig, Garen, Yuliya, Kolodenko, Alexander E, Gorbalenya, Eric J, Snijder, Michael N G, James

Publikováno v: The Journal of biological chemistry. 277(42)

Arteriviruses are enveloped, positive-stranded RNA viruses and include pathogens of major economic concern to the swine- and horse-breeding industries. The arterivirus replicase gene encodes two large precursor polyproteins that are processed by the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7e14ccca821023dd4bab217c37d97d59
https://pubmed.ncbi.nlm.nih.gov/12163505

Zobrazit plný text záznamu

Akademický článek

Crystal Structure of Î²-Hexosaminidase B in Complex with Pyrimethamine, a Potential Pharmacological Chaperone.

Autor: Katherine S. Bateman, Maia M. Cherney, Don J. Mahuran, Michael Tropak, Michael N. G. James

Publikováno v: Journal of Medicinal Chemistry; Mar2011, Vol. 54 Issue 5, p1421-1429, 9p

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání