Zobrazeno 1 - 10
of 369
pro vyhledávání: '"Michael Mullan"'
Autor:
Andrew Pearson, Milica Koprivica, Max Eisenbaum, Camila Ortiz, Mackenzie Browning, Tessa Vincennie, Cooper Tinsley, Michael Mullan, Fiona Crawford, Joseph Ojo
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-24 (2024)
Abstract Chronic neuroinflammation and microglial activation are key mediators of the secondary injury cascades and cognitive impairment that follow exposure to repetitive mild traumatic brain injury (r-mTBI). Peroxisome proliferator-activated recept
Externí odkaz:
https://doaj.org/article/af601eb6f8c0432d862b66228a94000f
Autor:
Camila Ortiz, Andrew Pearson, Robyn McCartan, Shawn Roche, Nolan Carothers, Mackenzie Browning, Sylvia Perez, Bin He, Stephen D. Ginsberg, Michael Mullan, Elliott J. Mufson, Fiona Crawford, Joseph Ojo
Publikováno v:
Journal of Neuroinflammation, Vol 21, Iss 1, Pp 1-24 (2024)
Abstract Epidemiological studies have unveiled a robust link between exposure to repetitive mild traumatic brain injury (r-mTBI) and elevated susceptibility to develop neurodegenerative disorders, notably chronic traumatic encephalopathy (CTE). The p
Externí odkaz:
https://doaj.org/article/812260dbcf494e8a958de716a1f01242
Autor:
Aurore Nkiliza, Claire J.C. Huguenard, Gregory J. Aldrich, Scott Ferguson, Adam Cseresznye, Teresa Darcey, James E. Evans, Michael Dretsch, Michael Mullan, Fiona Crawford, Laila Abdullah
Publikováno v:
Neurotrauma Reports, Vol 4, Iss 1, Pp 643-654 (2023)
Currently approved blood biomarkers detect intracranial lesions in adult patients with mild to moderate traumatic brain injury (TBI) acutely post-injury. However, blood biomarkers are still needed to help with a differential diagnosis of mild TBI (mT
Externí odkaz:
https://doaj.org/article/4d85eaf625a849fcbefcf0a7982e7839
Autor:
Robyn McCartan, Arissa Gratkowski, Mackenzie Browning, Coral Hahn-Townsend, Scott Ferguson, Alexander Morin, Corbin Bachmeier, Andrew Pearson, Larry Brown, Michael Mullan, Fiona Crawford, Radouil Tzekov, Benoit Mouzon
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 29, Iss , Pp 303-318 (2023)
Traumatic optic neuropathy (TON) is a condition in which acute injury to the optic nerve from direct or indirect trauma results in vision loss. The most common cause of TON is indirect injury to the optic nerve caused by concussive forces that are tr
Externí odkaz:
https://doaj.org/article/15a7789f959a45d3ba98ea59df966697
Autor:
Scott Ferguson, Robyn McCartan, Mackenzie Browning, Coral Hahn-Townsend, Arissa Gratkowski, Alexander Morin, Laila Abdullah, Ghania Ait-Ghezala, Joseph Ojo, Kimberly Sullivan, Michael Mullan, Fiona Crawford, Benoit Mouzon
Publikováno v:
Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-22 (2022)
Abstract Chemical and pharmaceutical exposures have been associated with the development of Gulf War Illness (GWI), but how these factors interact with the pathophysiology of traumatic brain injury (TBI) remains an area of study that has received lit
Externí odkaz:
https://doaj.org/article/f7e54544c7da46d0b526cdf3bd7de54b
Autor:
Alexander Morin, Roderick Davis, Teresa Darcey, Michael Mullan, Benoit Mouzon, Fiona Crawford
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-12 (2022)
Abstract Repetitive mild traumatic brain injury (r-mTBI) is the most widespread type of brain trauma worldwide. The cumulative injury effect triggers long-lasting pathological and molecular changes that may increase risk of chronic neurodegenerative
Externí odkaz:
https://doaj.org/article/c8bce0451c4145d3b6cabfaef75c0a43
Autor:
Ariane Menden, Davane Hall, Coral Hahn-Townsend, Courtney A. Broedlow, Utsav Joshi, Andrew Pearson, Fiona Crawford, James E. Evans, Nichole Klatt, Stefan Crynen, Michael Mullan, Ghania Ait-Ghezala
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract Alzheimer’s disease (AD) represents the most common form of dementia in the elderly with no available disease modifying treatments. Altered gut microbial composition has been widely acknowledged as a common feature of AD, which potentially
Externí odkaz:
https://doaj.org/article/ae27d950c5b64c019808ca68dc5cb0b7
Autor:
Sarah Oberlin, Aurore Nkiliza, Megan Parks, James E. Evans, Nancy Klimas, Andrew P. Keegan, Kimberly Sullivan, Maxine H. Krengel, Michael Mullan, Fiona Crawford, Laila Abdullah
Publikováno v:
Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract Background Nearly 250,000 veterans from the 1990–1991 Gulf War have Gulf War Illness (GWI), a condition with heterogeneous pathobiology that remains difficult to diagnose. As such, availability of blood biomarkers that reflect the underlyi
Externí odkaz:
https://doaj.org/article/bff3763129c3455eb2f8da3ca1d2b0d8
Autor:
Claire J. C. Huguenard, Adam Cseresznye, Teresa Darcey, Aurore Nkiliza, James E. Evans, Stanley L. Hazen, Michael Mullan, Fiona Crawford, Laila Abdullah
Publikováno v:
Frontiers in Aging Neuroscience, Vol 14 (2023)
With age the apolipoprotein E (APOE) E4 allele (involved in lipid homeostasis) is associated with perturbation of bioenergetics pathways in Alzheimer’s disease (AD). We therefore hypothesized that in aging mice APOE genotype would affect the L-carn
Externí odkaz:
https://doaj.org/article/be3bbcd4045d4e068a75155571bfe863
Autor:
Maxwell Eisenbaum, Andrew Pearson, Arissa Gratkowski, Benoit Mouzon, Michael Mullan, Fiona Crawford, Joseph Ojo, Corbin Bachmeier
Publikováno v:
Fluids and Barriers of the CNS, Vol 18, Iss 1, Pp 1-13 (2021)
Abstract Repetitive head trauma has been associated with the accumulation of tau species in the brain. Our prior work showed brain vascular mural cells contribute to tau processing in the brain, and that these cells progressively degenerate following
Externí odkaz:
https://doaj.org/article/62123cb0b1524b6c8ffeac43d3eb0097