Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Michael Morgen"'
Autor:
Jana Samarin, Piotr Fabrowski, Roman Kurilov, Hana Nuskova, Johanna Hummel-Eisenbeiss, Hannelore Pink, Nan Li, Vivienn Weru, Hamed Alborzinia, Umut Yildiz, Laura Grob, Minerva Taubert, Marie Czech, Michael Morgen, Christina Brandstädter, Katja Becker, Lianghao Mao, Ashok Kumar Jayavelu, Angela Goncalves, Ulrike Uhrig, Jeanette Seiler, Yanhong Lyu, Sven Diederichs, Ursula Klingmüller, Martina Muckenthaler, Annette Kopp-Schneider, Aurelio Teleman, Aubry K. Miller, Nikolas Gunkel
Publikováno v:
Redox Biology, Vol 62, Iss , Pp 102639- (2023)
Despite a strong rationale for why cancer cells are susceptible to redox-targeting drugs, such drugs often face tumor resistance or dose-limiting toxicity in preclinical and clinical studies. An important reason is the lack of specific biomarkers to
Externí odkaz:
https://doaj.org/article/43f98fcf2a844645aeeecc65e57523ec
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
The gold(I)‐dithiocarbamate (dtc) complex [Au(N,N‐diethyl)dtc]2 was identified as the active cytotoxic agent in the combination treatment of sodium aurothiomalate and disulfiram on a panel of cancer cell lines. In addition to demonstrating pronou
Autor:
Michael Morgen
Publikováno v:
Organic Syntheses. 98:171-193
Autor:
Michael Morgen
Publikováno v:
Organic Syntheses. 98:315-342
Autor:
Molly Adam, Warren Miller, Amanda Pluntze, Aaron Stewart, Jonathan Cape, Michael Grass, Michael Morgen
Publikováno v:
Pharmaceutics; Volume 14; Issue 3; Pages: 555
Many active pharmaceutical ingredients (APIs) in the pharmaceutical pipeline require bioavailability enhancing formulations due to very low aqueous solubility. Although spray dried dispersions (SDDs) have demonstrated broad utility in enhancing the b
Autor:
Corey J Herbst-Gervasoni, Aubry K. Miller, Michael Morgen, Raphael R. Steimbach, David W. Christianson
Publikováno v:
ACS Chem Biol
The cytosolic class IIb histone deacetylase HDAC10 is an emerging target for drug design. As an inducer of autophagy, its selective inhibition suppresses the autophagic response that otherwise attenuates the efficacy of cytotoxic cancer chemotherapy
Autor:
Nicholas J. Porter, Jeremy D. Osko, Ina Oehme, Olaf Witt, Johannes Ridinger, David W. Christianson, Peter Sehr, Corey J Herbst-Gervasoni, Aubry K. Miller, Magalie Géraldy, Lars Hellweg, Michael Morgen, Raphael R. Steimbach, Nikolas Gunkel
Publikováno v:
ChemMedChem
We report the synthesis and evaluation of a class of selective multitarget agents for the inhibition of HDAC6, HDAC8, and HDAC10. The concept for this study grew out of a structural analysis of the two selective inhibitors Tubastatin A (HDAC6/10) and
Autor:
Raphael R. Steimbach, Olaf Witt, Peter Sehr, Oliver Koch, Johannes Ridinger, Nikolas Gunkel, Ina Oehme, Mauro Oddo Nogueira, Magalie Géraldy, Michael Morgen, Davide Moi, Mona Malz, Aubry K. Miller
Publikováno v:
Journal of Medicinal Chemistry. 62:4426-4443
The discovery of isozyme-selective histone deacetylase (HDAC) inhibitors is critical for understanding the biological functions of individual HDACs and for validating HDACs as drug targets. The isozyme HDAC10 contributes to chemotherapy resistance an
Autor:
Mona Malz, Aubry K. Miller, Nikolas Gunkel, Oliver Koch, Mauro S. Nogueira, Olaf Witt, Ina Oehme, Johannes Ridinger, Raphael R. Steimbach, Peter Sehr, Michael Morgen, Magalie Géraldy
The discovery of isozyme-selective histone deacetylase (HDAC) inhibitors is critical for understanding the biological functions of individual HDACs and for validating HDACs as clinical drug targets. The isozyme HDAC10 contributes to chemotherapy resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d1a8d93f14f8e0cfcab9c9c7d8adb20
https://doi.org/10.26434/chemrxiv.7406618.v1
https://doi.org/10.26434/chemrxiv.7406618.v1
Publikováno v:
Inorganic Chemistry. 52:6481-6501
Bispidines (3,7-diazabicyclo[3.3.1]nonanes) as very rigid and highly preorganized ligands find broad application in the field of coordination chemistry, and the redox potentials of their transition-metal complexes are of importance in oxidation react