Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Michael Monine"'
Autor:
Alessio Paris, Pranami Bora, Silvia Parolo, Drew MacCannell, Michael Monine, Nick van derMunnik, Xiao Tong, Satish Eraly, Zdenek Berger, Danielle Graham, Toby Ferguson, Enrico Domenici, Ivan Nestorov, Luca Marchetti
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 2, Pp 196-206 (2023)
Abstract Phosphorylated neurofilament heavy subunit (pNfH) has been recently identified as a promising biomarker of disease onset and treatment efficacy in spinal muscular atrophy (SMA). This study introduces a quantitative systems pharmacology model
Externí odkaz:
https://doaj.org/article/9c84e240cf754f71aacd8847664a671a
Autor:
Alessio Paris, Pranami Bora, Silvia Parolo, Michael Monine, Xiao Tong, Satish Eraly, Eric Masson, Toby Ferguson, Alexander McCampbell, Danielle Graham, Enrico Domenici, Ivan Nestorov, Luca Marchetti
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 11, Iss 4, Pp 447-457 (2022)
Abstract Neurofilaments (Nfs) are the major structural component of neurons. Their role as a potential biomarker of several neurodegenerative diseases has been investigated in past years with promising results. However, even under physiological condi
Externí odkaz:
https://doaj.org/article/de1ae59bb53d404daed33a212cd550f8
Autor:
Mita Kuchimanchi, Michael Monine, Kumar Kandadi Muralidharan, Caroline Woodward, Natalia Penner
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 9, Pp 515-522 (2020)
This modeling and simulation analysis was aimed at selecting doses of cinpanemab (BIIB054), a monoclonal antibody targeting aggregated α‐synuclein, for a phase II study in Parkinson’s disease (PD). Doses and regimens were proposed based on antic
Externí odkaz:
https://doaj.org/article/dbffe77d3e484d199ea8344fe935395f
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e28758 (2012)
The linker for activation of T cells (LAT), the linker for activation of B cells (LAB), and the linker for activation of X cells (LAX) form a family of transmembrane adaptor proteins widely expressed in lymphocytes. These scaffolding proteins have mu
Externí odkaz:
https://doaj.org/article/42e94e3dd91b4a04aed8ea50477f7cf8
Autor:
Alessio Paris, Pranami Bora, Silvia Parolo, Drew MacCannell, Michael Monine, Nick van der Munnik, Xiao Tong, Satish Eraly, Zdenek Berger, Danielle Graham, Toby Ferguson, Enrico Domenici, Ivan Nestorov, Luca Marchetti
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology. 12:196-206
Phosphorylated neurofilament heavy subunit (pNfH) has been recently identified as a promising biomarker of disease onset and treatment efficacy in spinal muscular atrophy (SMA). This study introduces a quantitative systems pharmacology model represen
Publikováno v:
Journal of Pharmacokinetics and Pharmacodynamics. 48:639-654
Antisense oligonucleotides (ASOs) are promising therapeutic agents for a variety of neurodegenerative and neuromuscular disorders, e.g., Alzheimer's, Parkinson's and Huntington's diseases, spinal muscular atrophy (SMA) and amyotrophic lateral scleros
Autor:
Kumar Kandadi Muralidharan, Mita Kuchimanchi, Michael Monine, Caroline Woodward, Natalia Penner
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 9, Pp 515-522 (2020)
CPT: Pharmacometrics & Systems Pharmacology, Vol 9, Iss 9, Pp 515-522 (2020)
This modeling and simulation analysis was aimed at selecting doses of cinpanemab (BIIB054), a monoclonal antibody targeting aggregated α-synuclein, for a phase II study in Parkinson's disease (PD). Doses and regimens were proposed based on anticipat
Publikováno v:
mAbs
A thorough understanding of drug metabolism and disposition can aid in the assessment of efficacy and safety. However, analytical methods used in pharmacokinetics (PK) studies of protein therapeutics are usually based on ELISA, and therefore can prov
Autor:
Len M. Pismen, Michael Monine
Publikováno v:
Physical review. E, Statistical, nonlinear, and soft matter physics. 66(5 Pt 1)
Three-dimensional reconstruction and roughening of a Pt(110) surface is studied with the help of a qualitative Monte Carlo model. A distinct CO adsorption uptake on different surface phases is taken into account. The computations show that a ``missin