Pax6 limits the competence of developing cerebral cortical cells to respond to inductive intercellular signals.

Autor: Martine Manuel, Kai Boon Tan, Zrinko Kozic, Michael Molinek, Tiago Sena Marcos, Maizatul Fazilah Abd Razak, Dániel Dobolyi, Ross Dobie, Beth E P Henderson, Neil C Henderson, Wai Kit Chan, Michael I Daw, John O Mason, David J Price

Publikováno v: PLoS Biology, Vol 20, Iss 9, p e3001563 (2022)

The development of stable specialized cell types in multicellular organisms relies on mechanisms controlling inductive intercellular signals and the competence of cells to respond to such signals. In developing cerebral cortex, progenitors generate o

Externí odkaz: https://doaj.org/article/e095303f3e8640019b40c0c448f676c2

PAX6 LIMITS THE COMPETENCE OF DEVELOPING CEREBRAL CORTICAL CELLS

Autor: Martine Manuel, Kai Boon Tan, Zrinko Kozic, Michael Molinek, Tiago Sena Marcos, Maizatul Fazilah Abd Razak, Dániel Dobolyi, Ross Dobie, Beth E. P. Henderson, Neil C. Henderson, Wai Kit Chan, Michael I. Daw, John O. Mason, David J. Price

The development of stable specialized cell types in multicellular organisms relies on mechanisms controlling inductive intercellular signals and the competence of cells to respond to such signals. In developing cerebral cortex, progenitors generate o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fcb52e91c214a31c289a122f34df6701
https://doi.org/10.1101/2022.02.03.478927

Pax6 is required intrinsically by thalamic progenitors for the normal molecular patterning of thalamic neurons but not the growth and guidance of their axons

Autor: James M, Clegg, Ziwen, Li, Michael, Molinek, Isabel Martín, Caballero, Martine N, Manuel, David J, Price

Publikováno v: Neural Development

Background In mouse embryos, the Pax6 transcription factor is expressed in the progenitors of thalamic neurons but not in thalamic neurons themselves. Its null-mutation causes early mis-patterning of thalamic progenitors. It is known that thalamic ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ef65b8765016a378cd0c0a893c7123f7
https://pubmed.ncbi.nlm.nih.gov/26520399

Novel lines of Pax6-/- embryonic stem cells exhibit reduced neurogenic capacity without loss of viability

Autor: Tomasz J. Nowakowski, David Price, John O. Mason, Michael Molinek, Jane Quinn

Publikováno v: BMC Neuroscience, Vol 11, Iss 1, p 26 (2010)
Quinn, J C, Molinek, M, Nowakowski, T J, Mason, J O & Price, D J 2010, ' Novel lines of Pax6-/-embryonic stem cells exhibit reduced neurogenic capacity without loss of viability ', BMC Neuroscience, vol. 11, 26 . https://doi.org/10.1186/1471-2202-11-26
BMC Neuroscience

Background Embryonic stem (ES) cells can differentiate into all cell types and have been used extensively to study factors affecting neuronal differentiation. ES cells containing mutations in known genes have the potential to provide useful in vitro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52d1e5cc045f8592cb632fbb59b51bef
http://www.biomedcentral.com/1471-2202/11/26

Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization

Autor: T. Ian Simpson, Jane Quinn, Veronica van Heyningen, Thomas Pratt, John D. West, David A. Tyas, Dirk A. Kleinjan, John O. Mason, Simon A. Chanas, Martine Manuel, Petrina A. Georgala, Catherine B. Carr, Ben Martynoga, David Price, Jeni Pinson, Michael Molinek

Publikováno v: Manuel, M, Georgala, P A, Carr, C B, Chanas, S, Kleinjan, D A, Martynoga, B, Mason, J O, Molinek, M, Pinson, J, Pratt, T, Quinn, J C, Simpson, I, Tyas, D A, van Heyningen, V, West, J D & Price, D J 2007, ' Controlled overexpression of Pax6 in vivo negatively autoregulates the Pax6 locus, causing cell-autonomous defects of late cortical progenitor proliferation with little effect on cortical arealization ', Development, vol. 134, no. 3, pp. 545-55 . https://doi.org/10.1242/dev.02764

Levels of expression of the transcription factor Pax6 vary throughout corticogenesis in a rostro-lateralhigh to caudo-mediallow gradient across the cortical proliferative zone. Previous loss-of-function studies have indicated that Pax6 is required fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7516f2d40df7c7a24376a0b3495bd75f
https://pubmed.ncbi.nlm.nih.gov/17202185