Zobrazeno 1 - 10
of 253
pro vyhledávání: '"Michael Meyer-Hermann"'
Autor:
Mikhail Lebedin, Christoph Ratswohl, Amar Garg, Marta Schips, Clara Vázquez García, Lisa Spatt, Charlotte Thibeault, Benedikt Obermayer, January Weiner, 3rd, Ilais Moreno Velásquez, Cathrin Gerhard, Paula Stubbemann, Leif-Gunnar Hanitsch, Tobias Pischon, Martin Witzenrath, Leif Erik Sander, Florian Kurth, Michael Meyer-Hermann, Kathrin de la Rosa
Publikováno v:
iScience, Vol 27, Iss 3, Pp 109330- (2024)
Summary: Identifying immune modulators that impact neutralizing antibody responses against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is of great relevance. We postulated that high serum concentrations of soluble angiotensin-co
Externí odkaz:
https://doaj.org/article/7c9c5701df2748eb9bb1238451f24137
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionA protective humoral response to pathogens requires the development of high affinity antibodies in germinal centers (GC). The combination of antigens available during immunization has a strong impact on the strength and breadth of the ant
Externí odkaz:
https://doaj.org/article/a6212b5a50a5482a911a812a65a24950
Autor:
Rodrigo García-Valiente, Elena Merino Tejero, Maria Stratigopoulou, Daria Balashova, Aldo Jongejan, Danial Lashgari, Aurélien Pélissier, Tom G. Caniels, Mathieu A. F. Claireaux, Anne Musters, Marit J. van Gils, María Rodríguez Martínez, Niek de Vries, Michael Meyer-Hermann, Jeroen E. J. Guikema, Huub Hoefsloot, Antoine H. C. van Kampen
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-14 (2023)
Abstract Sequencing of B-cell and T-cell immune receptor repertoires helps us to understand the adaptive immune response, although it only provides information about the clonotypes (lineages) and their frequencies and not about, for example, their af
Externí odkaz:
https://doaj.org/article/44b6c99bb69541cc9cb23059ccbecc30
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The selection of high-affinity B cells and the production of high-affinity antibodies are mediated by T follicular helper cells (Tfhs) within germinal centres (GCs). Therein, somatic hypermutation and selection enhance B cell affinity but risk the em
Externí odkaz:
https://doaj.org/article/f2bf46eedb59447aba06618911ecd49a
Autor:
Arnab Bandyopadhyay, Marta Schips, Tanmay Mitra, Sahamoddin Khailaie, Sebastian C. Binder, Michael Meyer-Hermann
Publikováno v:
Communications Medicine, Vol 2, Iss 1, Pp 1-16 (2022)
Bandyopadhyay, Schips et al. model the factors contributing to overloading of healthcare facilities during the first COVID-19 wave in Italy. They predict that an early test and isolate intervention could have reduced healthcare usage and death rates
Externí odkaz:
https://doaj.org/article/0711f04ebb7f4d7ca6b5a3387bda26c9
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
A variety of B cell clones seed the germinal centers, where a selection stringency expands the fitter clones to generate higher affinity antibodies. However, recent experiments suggest that germinal centers often retain a diverse set of B cell clones
Externí odkaz:
https://doaj.org/article/7b289a69dfb44511a42e79358b2aa7ae
Autor:
Martin J. Kühn, Daniel Abele, Sebastian Binder, Kathrin Rack, Margrit Klitz, Jan Kleinert, Jonas Gilg, Luca Spataro, Wadim Koslow, Martin Siggel, Michael Meyer-Hermann, Achim Basermann
Publikováno v:
BMC Infectious Diseases, Vol 22, Iss 1, Pp 1-17 (2022)
Abstract Background Despite the vaccination process in Germany, a large share of the population is still susceptible to SARS-CoV-2. In addition, we face the spread of novel variants. Until we overcome the pandemic, reasonable mitigation and opening s
Externí odkaz:
https://doaj.org/article/6f1e120a7b334463919005c829d4af47
Autor:
Lito A. Papaxenopoulou, Gang Zhao, Sahamoddin Khailaie, Konstantinos Katsoulis-Dimitriou, Ingo Schmitz, Eva Medina, Haralampos Hatzikirou, Michael Meyer-Hermann
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105522- (2022)
Summary: Staphylococcus aureus can lead to chronic infections and abscesses in internal organs including kidneys, which are associated with the expansion of myeloid-derived suppressor cells (MDSCs) and their suppressive effect on T cells. Here, we de
Externí odkaz:
https://doaj.org/article/3ae64fc3a22646c0a5f7581564288b87
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Germinal centers (GCs) are transient structures where affinity maturation of B cells gives rise to high affinity plasma and memory cells. The mechanism of GC shutdown is unclear, despite being an important phenomenon maintaining immune homeostasis. I
Externí odkaz:
https://doaj.org/article/ebdacaacba3746f29bdaf95d9b8348eb
Autor:
Danial Lashgari, Elena Merino Tejero, Michael Meyer-Hermann, Mathieu A F Claireaux, Marit J van Gils, Huub C J Hoefsloot, Antoine H C van Kampen
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1010168 (2022)
Affinity maturation is an evolutionary process by which the affinity of antibodies (Abs) against specific antigens (Ags) increases through rounds of B-cell proliferation, somatic hypermutation, and positive selection in germinal centres (GC). The pos
Externí odkaz:
https://doaj.org/article/70672d97fb054db9b22c405c149345c9