Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Michael Mertzman"'
Autor:
Ryan, Moslin, Yanlei, Zhang, Stephen T, Wrobleski, Shuqun, Lin, Michael, Mertzman, Steven, Spergel, John S, Tokarski, Joann, Strnad, Kathleen, Gillooly, Kim W, McIntyre, Adriana, Zupa-Fernandez, Lihong, Cheng, Huadong, Sun, Charu, Chaudhry, Christine, Huang, Celia, D'Arienzo, Elizabeth, Heimrich, Xiaoxia, Yang, Jodi K, Muckelbauer, ChiehYing, Chang, Jeffrey, Tredup, Dawn, Mulligan, Dianlin, Xie, Nelly, Aranibar, Manoj, Chiney, James R, Burke, Louis, Lombardo, Percy H, Carter, David S, Weinstein
Publikováno v:
Journal of medicinal chemistry. 62(20)
As a member of the Janus (JAK) family of nonreceptor tyrosine kinases, TYK2 plays an important role in mediating the signaling of pro-inflammatory cytokines including IL-12, IL-23, and type 1 interferons. The nicotinamide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6a5ff3f143a4460f1c63e1a663ab705
https://pubmed.ncbi.nlm.nih.gov/31314518
https://pubmed.ncbi.nlm.nih.gov/31314518
Autor:
Martijn Fenaux, Stacey Eng, Stephanie A. Leavitt, Yu-Jen Lee, Eric M. Mabery, Yang Tian, Daniel Byun, Eda Canales, Michael O. Clarke, Edward Doerffler, Scott E. Lazerwith, Willard Lew, Qi Liu, Michael Mertzman, Philip Morganelli, Lianhong Xu, Hong Ye, Jennifer Zhang, Mike Matles, Bernard P. Murray, Judy Mwangi, Jingyu Zhang, Ahmad Hashash, Steve H. Krawczyk, Alison M. Bidgood, Todd C. Appleby, William J. Watkins
GS-9669 is a highly optimized thumb site II nonnucleoside inhibitor of the hepatitis C virus (HCV) RNA polymerase, with a binding affinity of 1.35 nM for the genotype (GT) 1b protein. It is a selective inhibitor of HCV RNA replication, with a mean 50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1d66793ecfe602fea0d21fe4a59c1e4
https://europepmc.org/articles/PMC3553741/
https://europepmc.org/articles/PMC3553741/
Publikováno v:
Journal of Heterocyclic Chemistry. 30:17-21
A series of substituted quinaldines was synthesized with much improved yields from the reaction of croton-aldehyde and the corresponding anilines using either p-chloranil or 2,3-dichloro-1,4-naphthoquinone as the oxidant.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26823389d5f34c457b12c33dcdf8b0c1
https://doi.org/10.1002/jhet.5570300103
https://doi.org/10.1002/jhet.5570300103
Publikováno v:
ChemInform. 24
A series of substituted quinaldines was synthesized with much improved yields from the reaction of croton-aldehyde and the corresponding anilines using either p-chloranil or 2,3-dichloro-1,4-naphthoquinone as the oxidant.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::13587aaac118ad9d3ff437fc34a52ee7
https://doi.org/10.1002/chin.199333175
https://doi.org/10.1002/chin.199333175